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REGiMMUNE presents enhanced efficacy data in preclinical transplantation models
Date:6/1/2009

Boston, MA June 1, 2009 REGiMMUNE Corporation today announced that its lead product candidate RGI-2001, in combination with a low-dose of Sirolimus, demonstrated enhanced efficacy in transplantation tolerance induction in models of skin transplantation and acute Graft-versus-Host disease (GvHD). This data is being presented today in a poster titled "Donor-Specific Tolerance Induction by a Liposomal Formulation of KRN7000 (RGI-2001) Alone and in Combination with Low-Dose Sirolimus" at the 2009 American Transplant Congress being held in Boston.

"We are extremely pleased to present this data," stated Haru Morita, President and Chief Executive Officer of REGiMMUNE. "The study not only demonstrated the efficacy of RGI-2001 in solid organ transplants; it showed the potential of RGI-2001 to induce antigen-specific transplantation tolerance, which is considered a holy grail in transplantation."

KRN7000, a synthetic derivative of alpha-galactosylceramide, is a small molecule that potently activates natural killer T (NKT) cells. RGI-2001 is a proprietary liposomal formulation of KRN7000. RGI-2001 monotherapy has shown to induce antigen-specific immune suppression by inducing regulatory T cells (Tregs). Tregs are believed to play a central role in inducing and maintaining immune tolerance. The study was designed to evaluate the efficacy of RGI-2001 in combination with Sirolimus in transplantation tolerance induction in mouse models.

Study Results

Pharmacological induction of alloantigen-specific tolerance is expected to provide significant clinical benefits in organ transplantation and bone marrow transplantation. The REGiMMUNE study concluded that the addition of a subtherapeutic dose of Sirolimus enhanced the efficacy of RGI-2001 in both models. The combination treatment significantly prolonged the survival of grafts in the skin transplant model over Sirolimus single treatment. Likewise, GvHD mortality was reduced
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Contact: Debra Bannister
530-676-8001
REGiMMUNE
Source:Eurekalert

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