Navigation Links
Quick, easy test identifies aggressive type of lung cancer in never-smokers
Date:2/25/2011

An inexpensive and rapid testing method can effectively identify a sub-group of never-smoking lung cancer patients whose tumors express a molecule associated with increased risk of disease progression or recurrence, US researchers have found.

Dr Ping Yang from the Mayo Clinic, Rochester, USA, and colleagues, reported the findings at the European Multidisciplinary Conference in Thoracic Oncology (EMCTO), 24-26 February 2011, Lugano, Switzerland.

Approximately 8% - 12% of patients with lung adenocarcinoma who have never smoked cigarettes carry tumors that express a protein product called anaplastic lymphoma kinase (ALK), Dr Yang said. "This subset of patients are at more than double the risk of experiencing disease progression or recurrence within 5 years of initial diagnosis compared to never-smokers whose lung adenocarcinoma tumors are ALK-negative."

The ability to test for ALK status in these patients may help doctors select the most appropriate therapies for maximum clinical benefit, Dr Yang explained. Her group's study aimed to see whether immunohistochemistry screening, followed by a confirmatory test using fluorescence in situ hybridization (FISH), is a practical way to do this.

Immunohistochemistry tests use antibodies to identify specific proteins in tissue sections; FISH uses fluorescent probes to bind to specific DNA sequences in the chromosomes of individual cells.

In a study of 303 samples, the research team found that immunohistochemistry results correlated well with the results of FISH. Tissue samples with the highest immunohistochemistry scores (IHC 3+) were all FISH positive, while those with no immunohistochemistry staining (IHC 0) were FISH negative.

Based on these findings, only samples that were scored with the intermediate IHC scores of 1+ and 2+ would need confirmatory testing with FISH, Dr Yang explained. "In this particular cohort, IHC score 2+ and 1+ cases represented approximately
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pitt-led researchers create quick, simple fluorescent detector for TB
2. Needle-in-a-haystack search identifies potential brain disease drug
3. UCSF study identifies chemicals in pregnant women
4. Study identifies new genetic signatures of breast cancer drug resistance
5. Research identifies drug target for prion diseases, mad cow
6. Large-scale analysis identifies new genetic alterations associated with height
7. Virginia Tech engineer identifies new concerns for antibiotic resistance, pollution
8. Transcription factor scan identifies genetic cause for inherited blindness
9. Motor Neurone Disease Association study identifies MND biomarker
10. New research identifies the plight of farmland birds
11. Study identifies key molecules in multiple myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... CIE San Diego has launched an innovative ... tissue that enhances care coordination among social service and ... information; earned a second $1 million grant from the ... aging in community and; will be recognized as a ... 4-6p. CIE San Diego today announced ...
(Date:12/5/2014)... 2014 Increased emphasis on product quality, ... testing and inspection technologies. The convergence of industries ... range of innovative test solutions. This trend is ... which is generally more inclined towards communication, media ... strategies of test equipment vendors will cater to ...
(Date:12/3/2014)... 2014   Marvin Test Solutions , a ... for military, aerospace, and manufacturing organizations, today announced ... TS-900 PXI semiconductor test platform . The ... systems to customers at a fraction of the ... ATE. "Our semiconductor customers asked ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... vegetables is a new, patented technology in which a low-energy ... information on produce, thereby eliminating the need for common sticker-type ... variety of fruits and vegetables and is being used in ... been approved in Asia, South Africa, Central and South America, ...
... Samueli School of Engineering and Applied Science have for ... enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. ... in the journal Science , could potentially lead ... effects. The lovastatin-synthesizing enzyme is ...
... delicate, colorful flowers and furry, soft leaves make them ... striking plants are often regarded as temperamental: a precise ... fertilizer is required to encourage african violets to grow ... Julia C. Brotton and Janet C. Cole from the ...
Cached Biology News:Laser etching safe alternative for labeling grapefruit 2UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin 2For African violets, 'hands off' means healthier 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Blood America, Inc . ( www.cordblood-america.com ) (OTC Bulletin Board: ... cell preservation company focused on bringing the life saving ... announced revenues of $2.89 million for the first six months ... million in the same period in 2010.  Revenues for the ...
... IQ is pioneering new compound management discussion platform with launch of ... Integrity Online event, which will take an innovative form of ... 31 st   of October 2011. ... the agenda for many organisations and this was recently recognised by ...
... ALBUQUERQUE, N.M., Aug. 10, 2011 Exagen Diagnostics, ... discovers, develops and markets proprietary tests for rheumatologists and ... President and Chief Operating Officer. Tornoe has ... sales, sales management and marketing, making him a key ...
Cached Biology Technology:Cord Blood America Six Month Revenues Up 61 Percent; Gross Profit Up 100 Percent 2Cord Blood America Six Month Revenues Up 61 Percent; Gross Profit Up 100 Percent 3Compound Management and Integrity Goes Online 2Compound Management and Integrity Goes Online 3Eric Tornoe Joins Exagen Diagnostics as President and COO 2
Vertical Rack (five box vapor phase rack), includes 2.0" (5.1cm) boxes...
... and M.W. Turner (1997). • This ... used in the production of high-quality ... immunoassays, the standardisation of antibodies and ... amplification systems, enzyme immunoassays for detecting ...
... Casein Kinase 1, active MW: 34.2kDa ... NaCl, 0.02% Brij-35, 1mM dithiothreitiol with ... data, refer to the Certificate of ... Purification: ammonium salt precipitation followed by ...
MitoScreen (JC-1) Kit , 100 tests Consult technical datasheet for details....
Biology Products: