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Quest for genes involved in celiac disease
Date:4/5/2011

ing those which are especially susceptible to CD. In fact, thanks to the work, Ms Castellanos was able to distinguish, in the anatomical regions closely linked to CD, a number of genes subjected to alterations in their expression caused by gliadine (a protein that forms part of gluten), and she verified that these genes are candidates for being functionally involved with CD.

Besides this, based on information obtained from intestinal biopsies of the celiac patients, she was able to undertake an analysis and a general description of the alterations in expression caused by gliadine in the intestinal mucous. Given all this, Ms Castellanos concluded that, in those cases in which there is CD, malfunctions in intercellular communication, in intracellular signalling, in ubiquitine proteins and in a number of other networks are produced. Thus, she confirmed that CD is a complex and multifactorial illness. Moreover, on describing the changes happening with the levels of expression, she has provided guidelines on understanding how CD develops and found new factors which influence this progress of the disease.

Ubiquitine D

Amongst the networks mentioned previously, Ms Castellanos stressed the ubiquitine proteins, concretely ubiquitine D (UBD). An over-expression of UBD in the intestinal biopsies of the celiac patients and, in relation to this, a genetic variant or polymorphism linked to CD. As she explains in her thesis, this polymorphism could precisely be the inductor of this over-expression. Ms Castellanos stressed that the same could happen with other genes, candidates for being involved in CD. As a consequence, the example of UBD has confirmed that the observation of the genetic expressions can help in finding those genes which, while being unknown as yet, are linked to the onset of CD.


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Contact: Amaia Portugal
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Elhuyar Fundazioa
Source:Eurekalert

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