Navigation Links
Quest for edible malarial vaccine leads to other potential medical uses for algae
Date:4/19/2013

Can scientists rid malaria from the Third World by simply feeding algae genetically engineered with a vaccine?

That's the question biologists at UC San Diego sought to answer after they demonstrated last May that algae can be engineered to produce a vaccine that blocks malaria transmission. In a follow up study, published online today in the scientific journal Applied and Environmental Microbiology, they got their answer: Not yet, although the same method may work as a vaccine against a wide variety of viral and bacterial infections.

In their most recent study, which the authors made freely available on the Applied and Environmental Microbiology website at http://aem.asm.org/, the researchers fused a protein that elicits an antibody response in mice against the organism that causes malaria, Plasmodium falciparum, which afflicts 225 million people worldwide, with a protein produced by the bacterium responsible for cholera, Vibrio cholera, that binds to intestinal epithelial cells. They then genetically engineered algae to produce this two-protein combination, or "fusion protein," freeze dried the algae and later fed the resulting green powder to mice. The researchers hypothesized that together these proteins might be an effective oral vaccine candidate when delivered using algae.

The result? The mice developed Immunoglobulin A (IgA) antibodies to both the malarial parasite protein and to a toxin produced by the cholera bacteria. Because IgA antibodies are produced in the gut and mucosal linings, they don't protect against the malarial parasites, which are injected directly into the bloodstream by mosquitoes. But their study suggests that similar fusion proteins might protect against infectious diseases that affect mucosal linings using their edible freeze-dried algae.

"Many bacterial and viral infections are caused by eating tainted food or water," says Stephen Mayfield, a pro
'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Reliability of neuroscience research questioned
2. Researchers question evaluation methods for protected areas in the Amazon
3. After the Genome tackles tough questions about medicine, miracles and morality
4. Study questions the role of kinship in mass strandings of pilot whales
5. Sequester will have a devastating impact on americas research enterprise
6. Sequestration will be a devastating blow to the nations research institutions and scientists
7. Yeast we can! New report answers questions on microbiology and beer
8. Graduate student video on sequestration wins prize
9. New protocol recommendations for measuring soil organic carbon sequestration
10. New Geology study raises questions about long-held theories of human evolution
11. Aztec conquest altered genetics among early Mexico inhabitants, new DNA study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE ... collaboration catalyst that provides the connective tissue that enhances ... enabling them to easily share client-level information; earned a ... to expand to organizations serving seniors aging in community ... Diego" partner on December 11 th 4-6p. ...
(Date:12/5/2014)... 2014  Tute Genomics, a leader in cloud-based solutions ... A1 funding led by UK-based Eurovestech. Peak Ventures and ... investment round. "We are at a pivotal ... sequencing and seeks new approaches for the diagnosis, treatment ... MD MBA, and CEO of Tute Genomics. "One of ...
(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... performed by the team of Dr. Nabil G. Seidah, ... IRCM, shows for the very first time that the ... responsible for removing the bad cholesterol (LDL-cholesterol) from the ... A2. This major discovery co-authored by Gatan Mayer, a ...
... produce the greenhouse gases, methane and carbon dioxide, as ... of a landfill, a process known as ,Phytocapping, could ... to Australian scientists writing in a forthcoming issue of ... Despite legislative pressures to reduce landfill use, in ...
... oceans are our climate regulators, cover the sites of ... records of the Earth,s history in store for us. ... light on both the deep and shallow (sub-) seafloors ... sciences. The European Science Foundation,s (ESF) European ...
Cached Biology News:A scientific breakthrough on the control of the bad cholesterol 2Putting a green cap on garbage dumps 2Europe cores in EUROCORES: Ocean drilling in EuroMARC 2Europe cores in EUROCORES: Ocean drilling in EuroMARC 3Europe cores in EUROCORES: Ocean drilling in EuroMARC 4Europe cores in EUROCORES: Ocean drilling in EuroMARC 5
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Claire, Wis. - To complement the two- and four-port ... Tree Communications has released software for Apple G4 and ... one interface with more bandwidth. , ,The company is the ... and Power Mac platforms. In March, it expanded from the ...
... Medical College of Wisconsin has implemented IBM s ... infrastructure support system for proteomics research. IBM announced last month ... on Power Architecture will begin shipping in volume globally ... site to test the Sequest application on the JS20 running ...
... made clear that China represents phenomenal opportunities for Wisconsin ... doing business in China and other parts of the ... property and technology. , ,On the mission ... despite the efforts of both businesses and the Chinese ...
Cached Biology Technology:Small Tree boosts bandwidth for Apple G4 and G5 servers 2Medical College of Wisconsin enhances research with IBM Blade server 2Protecting your intellectual property in overseas markets 2
...
Troponin I Immunogen: Full length native protein (purified) (Human). Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
Biology Products: