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Quest for better treatment for effects of menopause
Date:5/28/2008

, Doctor Ruiz del Agua states that the response to the treatments studied depends on the genetic burden of each patient, this response being favourable or otherwise, depending on the genetic variables carried by the women for the genes analysed.

In the case of hormonal therapies, carriers of the GG genotype (a combination highly frequent in the mpo gene) undergo a drop in the antioxidant activity of the serum, which means, in this sense, a favourable response to the treatment. In the case of raloxifene, only those women who, because of their genetic burden, are disfavoured for the antioxidant activity of arilesterase, gain benefit thanks to the treatment.

In short, this PhD presented at the UPV/EHU shows that certain aspects of treatments employed in postmenopausic women can be approached from an analysis of genetic polymorphisms, a fact which will contribute to the design of more personalised therapies for their application in postmenopause.


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Contact: Alaitz Ochoa de Eribe
alaitzo@elhuyar.com
34-688-673-679
Elhuyar Fundazioa
Source:Eurekalert

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