Navigation Links
Queen's study connects obesity with nervous system
Date:1/23/2008

KINGSTON, ON A discovery by Queens biologists and their students sheds new light on the genetic roots of obesity a condition that is increasing dramatically in North America and has been linked to heart disease, diabetes and some forms of cancer.

The new findings may also help to unlock the mystery of how our nervous systems control obesity.

Published on-line this week in the journal Proceedings of the National Academy of Sciences, the study was partially funded by the Natural Sciences and Engineering Research Council of Canada (NSERC).

Professors William Bendena and Ian Chin-Sang teamed up to work with tiny, transparent worms that have similar neurotransmitters (chemicals that transmit nerve impulses) as humans. They discovered that when a specific nerve receptor is deleted, the worms lose interest in foraging for food, become slow-moving and accumulate fat at a much higher rate than normal, non-modified, worms.

Although there is a wealth of scientific data currently being collected regarding classic brain neurotransmitters, its still uncertain how neuron connections may be either stimulatory or inhibitory in various organisms, notes Dr. Bendena. Our breakthrough came when Dr. Chin-Sang localized the worms receptor to one specific connecting nerve cell.

The worms that had their receptor deleted showed no difference in behaviour from other, non-altered worms until placed directly on food. Then they stopped their normal foraging behaviour, dramatically slowing their movements, and gained fat more quickly than worms with their receptors intact.

When extra copies of the receptor were added to the mutant worms, they became hyperactive and traveled large distances away from their food.

Drs. Bendena and Chin-Sang conclude that this type of receptor is an inhibitory switch within one connecting cell, and that worms defective in the receptor will gain fat. Such clearly affected behaviour and physiological changes have never been seen nor understood until this discovery, says Dr. Bendena. We hope that this will provide a basis for further research to unlock the mystery of the long-awaited nervous system connection to obesity.


'/>"/>

Contact: Nancy Dorrance
nancy.dorrance@queensu.ca
613-533-2869
Queen's University
Source:Eurekalert

Related biology news :

1. For honey bee queens, multiple mating makes a difference
2. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
3. A study by the MUHC and McGill University opens a new door to understanding cancer
4. Study begins to reveal clues to the cause and progression of sepsis
5. Clones on task serve greater good, evolutionary study shows
6. New study warns limited carbon market puts 20 percent of tropical forest at risk
7. New study examines how rearing environment can alter navigation
8. Study links cat disease to flame retardants in furniture and to pet food
9. New continent and species discovered in Atlantic study
10. Study shows link between alcohol consumption and hiv disease progression
11. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... 2017 A new report by Allied Market Research, titled, "Global ... technology market is expected to generate revenue of $10.72 billion by 2022, with an ... Reading ... Allied Market Research Logo ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) In the year ...
(Date:1/6/2017)... 5, 2017  SomaLogic announced today that it ... established by iCarbonX, the China ... "Global Digital Health Ecosystem that can define each ... individual,s biological, behavioral and psychological data, the Internet ... companies, SomaLogic will provide proteomics data and applications ...
(Date:1/3/2017)... 2017 Onitor, provider of digital health technology ... an innovative biometric data-driven program designed to aid weight ... the 2017 Consumer Electronics Show (CES) in ... U.S., the World Health Organization (WHO), have identified lifestyle ... who are overweight or obese. WHO also states that ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... CALABASAS, Calif. , Jan. 19, 2017 /PRNewswire/ ... Mathias Schmidt , Ph.D., as chief executive ... board of directors. Dr. Schmidt brings to ArmaGen more ... on the research and development of biotherapeutics and ... biopharmaceutical executive with the diverse experience and skillset ...
(Date:1/19/2017)... Linda, Ca (PRWEB) , ... January 18, 2017 ... ... virtual events for tech innovators, engineers, and scientists from around the world, was ... American News. The awards program is based entirely on merit and decided upon ...
(Date:1/19/2017)... YORK , Jan. 18, 2017 ... to reach USD 92.9 billion by 2025, according ... Inc. Pharmaceutical industry has been adaptive of the ... as early as 2002. Among the services outsourced, ... forerunners. For instance, Johnson & Johnson was the ...
(Date:1/19/2017)... -- BD (Becton, Dickinson and Company) (NYSE: BDX ), ... a live webcast of its Annual Meeting of Shareholders on Tuesday, ... webcast can be accessed from the BD corporate website at ... 2017. ... BD BD is a global medical technology company that is ...
Breaking Biology Technology: