Navigation Links
Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
Date:2/1/2013

Philadelphia, Pa. The shortened daylight of a Maine winter may make for long, dark nights but it has shone a light on a novel experimental approach to fighting inflammatory breast cancer (IBC), an especially deadly form of breast cancer.

The new approach enlists the active form of Vitamin D3, called calcitriol, which is delivered therapeutically by quantum dots. Quantum dots are an engineered light-emitting nanoscale delivery vehicle. This new preliminary work shows the dots can be used to rapidly move high concentrations of calcitriol to targeted tumor sites where cancer cells accumulate, and also through the lymph system where the cancer spreads. With this approach, the calcitriol can fight on multiple fronts and the targeted location can be visualized with an imaging system tracking the quantum dots. The research will be presented at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

University of Delaware cancer researcher Anja Nohe was living in Maine when she first received funding from the Maine Cancer Foundation to determine the effect of calcitriol on breast cancer cells. Reading cancer literature helped her make connections between cancer, vitamin D, and the daylight regime of higher latitudes. "By talking with talented colleagues about these ideas, the foundation was set for the current project," she says. After moving to the University of Delaware, she began working with Kenneth Van Golen, "an expert in the biology of IBC," to evaluate calcitriol.

Compared to other forms of breast cancer, IBC is especially difficult to treat. It has a five-year survival rate of 40% versus 87% for all other breast cancers. A big part of what makes IBC treatment difficult is its multi-site growth pattern. Current aggressive treatments such as combinations of chemotherapy, surgery and radiation, have failed to significantly improve IBC survival rates.

This early experimental work on mice is encouraging because data show calcitriol can inhibit invasion and migration of SUM149 cells, an IBC cell line. "New IBC therapies are urgently needed, which is why the goal of my work is to find a successful treatment for inflammatory breast cancer, especially one with fewer side effects," Nohe says.


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Good news for nanomedicine: Quantum dots appear safe in pioneering study on primates
2. High Brightness Tetrapod Quantum Dots Developed
3. Quantum communication: Each photon counts
4. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
5. Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
6. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
7. Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
8. Cancerous tumors deliver pro-metastatic information in secreted vesicles
9. iView Systems iTrakĀ® version 5.5 delivers optimized Incident Reporting
10. Light-induced delivery of nitric oxide eradicates drug-resistant bacteria
11. OSCs Oakley Cluster delivers on performance efficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... Rising sales of consumer electronics ... intuitive gesture control market size ... consumer electronics coupled with new technological advancements to drive ... through 2020   --> ... advancements to drive global touchfree intuitive gesture control market ...
(Date:2/1/2016)... , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) ... television personality, Joey Fatone . Las Vegas ... fans. --> Las Vegas , where Joey ... --> The new video ad was filmed at the Consumer Electronics ... at the Wocket booth to meet and greet fans. ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... Sinovac Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: ... China , today announced that the ... February 4, 2016 a preliminary non-binding proposal letter, dated ... V-Ming ( Shanghai ) Investment Holdings Co., ... Shenzhen ) Fund Management Co., Ltd., Beijing ...
(Date:2/3/2016)...  Discovery Laboratories, Inc. (NASDAQ: DSCO ), ... surfactant therapies for respiratory diseases, today announced that ... award as a component of employment compensation for ... and Chief Executive Officer.  The award was approved ... 2016 and granted as an inducement material to ...
(Date:2/3/2016)... ... February 03, 2016 , ... Aerocom, a ... dedicated to the North American healthcare market. , Aerocom Healthcare, LLC will be ... The company will provide new pneumatic tube systems or expand existing systems within ...
(Date:2/3/2016)... 3, 2016  Today, Symphony Technology Group (STG) announced ... a leading provider of primary research and analytics-based insight ... Health , a global information and technology services company ... technologies will be integrated into IMS Health to form ... research capabilities. ...
Breaking Biology Technology: