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Quantitative PET imaging finds early determination of effectiveness of cancer treatment
Date:10/23/2007

er two cycles of chemotherapy, and tumor response was assessed visually and by various quantitative parameters, explained the co-author of Early 18F-FDG PET for Prediction of Prognosis in Patients With Diffuse Large B-Cell Lymphoma: SUV-Based Assessment Versus Visual Analysis. Meignan said, We found that quantification of tumor FDG uptake (the ratio of tissue radioactivity concentration) can markedly improve the accuracy of FDG PET for prediction of patient outcome. Additional studies need to be done, said Meignan, reiterating that the future monitoring of cancer tumor response will probably include a combination of quantitative analysis and visual assessment.

PET is a powerful molecular imaging procedure that uses very small amounts of radioactive materials that are targeted to specific organs, bones or tissues. When PET is used to image cancer, a radiopharmaceutical (such as FDG, which includes both a sugar and a radionuclide) is injected into a patient. Cancer cells metabolize sugar at higher rates than normal cells, and the radiopharmaceutical is drawn in higher amounts to cancerous areas. PET scans show where FDG is by tracking the gamma rays given off by the radionuclide tagging the drug and producing three-dimensional images of their distribution within the body. PET scanning provides information about the bodys chemistry, metabolic activity and body function.


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Contact: Maryann Verrillo
mverrillo@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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