Navigation Links
Quantitative PET imaging finds early determination of effectiveness of cancer treatment
Date:10/23/2007

RESTON, Va.With positron emission tomography (PET) imaging, seeing is believing: Evaluating a patients response to chemotherapy for non-Hodgkin lymphoma (NHL) typically involves visual interpretation of scans of cancer tumors. Researchers have found that measuring a quantitative indexone that reflects the reduction of metabolic activity after chemotherapy first beginsadds accurate information about patients responses to first-line chemotherapy, according to a study in the October issue of the Journal of Nuclear Medicine.

In our study, we demonstrated that a quantitative assessment of therapeutic response for patients with diffuse large B-cell lymphoma (DLBCL) is more accurate than visual analysis alone when using the radiotracer FDG (fluorodeoxyglucose) with PET scans, said Michel Meignan, professor of nuclear medicine at Henri Mondor Hospital in Creteil, France. The ability to predict tumor response early in the course of treatment is very valuable clinically, allowing intensification of treatment in those patients who are unlikely to response to first-line chemotherapy, he added. Similarly, treatment could possibly be shortened in those patients who show a favorable response after one or two cycles of chemotherapy, and quantification also may help identify the diseases transformation from low-grade to aggressive stage, he explained. However, visual interpretation of PET scans will always be the first step of analysis and will prevail in case of difficulties to quantify images, added Meignan.

Diffuse large B-cell lymphoma is a fast-growing, aggressive form of non-Hodgkin lymphoma, a cancer of the bodys lymphatic system. Although there are more than 20 types of NHL, DLBCL is the most common type, making up about 30 percent of all lymphomas. In the United States, about 63,190 people are expected to be diagnosed with non-Hodgkin lymphoma in 2007, according to recent statistics.

Ninety-two patients with DLBCL were studied before and after two cycles of chemotherapy, and tumor response was assessed visually and by various quantitative parameters, explained the co-author of Early 18F-FDG PET for Prediction of Prognosis in Patients With Diffuse Large B-Cell Lymphoma: SUV-Based Assessment Versus Visual Analysis. Meignan said, We found that quantification of tumor FDG uptake (the ratio of tissue radioactivity concentration) can markedly improve the accuracy of FDG PET for prediction of patient outcome. Additional studies need to be done, said Meignan, reiterating that the future monitoring of cancer tumor response will probably include a combination of quantitative analysis and visual assessment.

PET is a powerful molecular imaging procedure that uses very small amounts of radioactive materials that are targeted to specific organs, bones or tissues. When PET is used to image cancer, a radiopharmaceutical (such as FDG, which includes both a sugar and a radionuclide) is injected into a patient. Cancer cells metabolize sugar at higher rates than normal cells, and the radiopharmaceutical is drawn in higher amounts to cancerous areas. PET scans show where FDG is by tracking the gamma rays given off by the radionuclide tagging the drug and producing three-dimensional images of their distribution within the body. PET scanning provides information about the bodys chemistry, metabolic activity and body function.


'/>"/>

Contact: Maryann Verrillo
mverrillo@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related biology news :

1. Imaging Lymph Nodes with Nanoparticles
2. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
3. Special Imaging Study Shows Failing Hearts Are Energy Starved
4. Duke engineers develop new 3-D cardiac imaging probe
5. Confocal imaging promises early detection of skin cancer
6. Newer imaging techniques may lead to over-treatment
7. Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
8. Microscopic brain imaging in the palm of your hand
9. New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
10. Purdues gold nanorods brighten future for medical imaging
11. PET imaging reveals the immune system at work
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: