Navigation Links
Quality control of mitochondria as a defense against disease
Date:1/21/2014

HEIDELBERG, 20 January 2014 Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes linked to hereditary Parkinson's disease are involved in the early-stage quality control of mitochondria. The protective mechanism, which is reported in The EMBO Journal, removes damaged proteins that arise from oxidative stress from mitochondria.

"PINK1 and parkin, are implicated in selectively targeting dysfunctional components of mitochondria to the lysosome under conditions of excessive oxidative damage within the organelle," said Edward Fon, Professor at the McGill Parkinson Program at the Montreal Neurological Institute and Hospital. "Our study reveals a quality control mechanism where vesicles bud off from mitochondria and proceed to the lysosome for degradation. This method is distinct from the degradation pathway for damaged whole mitochondria which has been known for some time. It is also an early response, proceeding on a timescale of hours instead of days."

The deterioration of mechanisms designed to maintain the integrity and function of mito-chondria throughout the lifetime of a cell has been suggested to underlie the progression of several neurodegenerative diseases, including Parkinson's disease. When mitochon-dria, the "power plants" of the cell that provide energy, malfunction they can contribute to Parkinson's disease. If they are to survive and function mitochondria need to degrade oxidized and damaged proteins.

In the study, immunofluorescence and confocal microscopy were used to observe how the vesicles "pinch off" from mitochondria with their damaged cargo. "Our conclusion is that the loss of this PINK1 and parkin-dependent trafficking system impairs the ability of mitochondria to selectively degrade oxidized and damaged proteins and leads, over time, to the mitochondrial dysfunction noted in hereditary Parkinson's disease," said Hei-di McBride, Professor in the Neuromuscular Group in the Department of Neurology and Neurosurgery at the Montreal Neurological Institute and Hospital. Both salvage pathways are operational in the cell. If the vesicular pathway, the first line of defense, is overwhelmed and the damage is irreversible then the entire organelle is targeted for degradation.


'/>"/>

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Related biology news :

1. Updating air pollution measurement methods with air quality, health effects research
2. Testosterone in male songbirds may enhance desire to sing but not song quality
3. Harvard study shows sprawl threatens water quality, climate protection, and land conservation gains
4. Quality of biodiversity, not just quantity, is key
5. Zinc sulfate, sugar alcohol zinc sprays improve apple quality
6. Protein quality: It matters
7. Enrollment in SNAP does not substantially improve food security or dietary quality
8. Clean Air Act has led to improved water quality in the Chesapeake Bay watershed
9. Laser technology sorting method can improve Capsicum pepper seed quality
10. New report reviews science and engineering quality at national security laboratories
11. UCLA scientists receive $2 million grant to improve quality of donor livers for transplant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent communities of bacteria that ... ranging from food poisoning and catheter infections to gum disease and the rejection of ... billions of dollars per year, there is currently a paucity of means for preventing ...
(Date:5/22/2017)... ... May 22, 2017 , ... Cancer diagnostics and pathology ... B2 at the Association for Pathology Informatics Annual Summit at the ... demonstrating its Cancer Diagnostic Cockpit and Consultation Portal, Inspirata will present research it ...
(Date:5/18/2017)... , ... May 18, 2017 , ... ... on April 28, 2017 at the Prince Of Wales Private Hospital. The procedure ... at level C6-C7. The patient failed conservative treatments prior to undergoing surgery. , ...
(Date:5/18/2017)... ... May 17, 2017 , ... Cognition Corporation ( ... just released version 9.0 of the Cognition Cockpit platform. , “Our whole team ... David Cronin, CEO of Cognition. “We’re thrilled to finally be able to release ...
Breaking Biology Technology: