Navigation Links
'Quadruple helix' DNA discovered in human cells
Date:1/20/2013

und that by trapping the quadruplex DNA with synthetic molecules we can sequester and stabilise them, providing important insights into how we might grind cell division to a halt," said Balasubramanian.

"There is a lot we don't know yet. One thought is that these quadruplex structures might be a bit of a nuisance during DNA replication - like knots or tangles that form.

"Did they evolve for a function? It's a philosophical question as to whether they are there by design or not - but they exist and nature has to deal with them. Maybe by targeting them we are contributing to the disruption they cause."

The study showed that if an inhibitor is used to block DNA replication, quadruplex levels go down - proving the idea that DNA is dynamic, with structures constantly being formed and unformed.

The researchers also previously found that an overactive gene with higher levels of Quadruplex DNA is more vulnerable to external interference.

"The data supports the idea that certain cancer genes can be usefully interfered with by small molecules designed to bind specific DNA sequences," said Balasubramanian.

"Many current cancer treatments attack DNA, but it's not clear what the rules are. We don't even know where in the genome some of them react - it can be a scattergun approach.

"The possibility that particular cancer cells harbouring genes with these motifs can now be targeted, and appear to be more vulnerable to interference than normal cells, is a thrilling prospect.

"The 'quadruple helix' DNA structure may well be the key to new ways of selectively inhibiting the proliferation of cancer cells. The confirmation of its existence in human cells is a real landmark."


'/>"/>

Contact: Fred Lewsey
fred.lewsey@admin.cam.ac.uk
44-078-857-98680
University of Cambridge
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First description of a triple DNA helix in a vacuum
2. Doubling the information from the double helix
3. Unexpected crustacean diversity discovered in northern freshwater ecosystems
4. University of Alberta led research may have discovered how memories are encoded in our brains
5. Newly discovered foot points to a new kid on the hominin block
6. New immune defense enzyme discovered
7. New genetic mechanism of immune deficiency discovered
8. Housekeeping mechanism for brain stem cells discovered
9. Scientists have discovered genes that increase the risk of osteoporosis and fractures
10. New form of intellectual disability discovered
11. 24 new species of lizards discovered on Caribbean islands are close to extinction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 2015 Research and Markets ( ... "Global Biometrics Market (2014-2020): Market Forecast By ... report to their offering. , ... is anticipated to overtake North ... government spending towards IT security, government biometric based ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the ... report to their offering. , The ... individual is who she/he is claiming to be, and for ... unique physical characteristics, such as fingerprint, hand or palm print, ...
(Date:1/22/2015)... 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), the ... campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz will ... capacity to meet customer demand. Logo ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by Dr. ...
Breaking Biology News(10 mins):Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2
... PASADENA, Calif.The frontal lobes are the largest part of ... that expanded most during human evolution. Damage to the ... eyescan result in profound impairments in higher-level reasoning and ... parts of the frontal lobes do, neuroscientists at the ...
... London and the University of Exeter Medical School has identified ... responsible for controlling eye muscles, resulting in movement disorders such ... could provide the key to reversing the condition and unlocking ... body. The research is published in Proceedings of ...
... Life in the world,s oceans faces far greater change and ... human history, a team of the world,s leading marine scientists ... Germany, Panama, Norway and the UK have compared events which ... what is observed to be taking place in the seas ...
Cached Biology News:Thinking and choosing in the brain 2Thinking and choosing in the brain 3Research identifies mechanism responsible for eye movement disorder 2Research identifies mechanism responsible for eye movement disorder 3Sea life 'facing major shock' 2Sea life 'facing major shock' 3
(Date:3/3/2015)... 3, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... are for odour control projects in North America ... Asia . "Bidding activity in 2015 continues to ... "After a high volume year for bidding in 2014, we are ... The recent orders reflect the organization,s renewed focus on select market ...
(Date:3/3/2015)... , March 3, 2015 Adaptive Biotechnologies ... CFO, is joining its Board of Director as Chair ... officer at Zillow Group, Chad oversees all finance, treasury ... built the company,s core finance, treasury and accounting functions, ... and nine acquisitions. In 2013, he was named Puget ...
(Date:3/3/2015)... March 3, 2015 Fried, Frank, Harris, Shriver ... Lewis has joined the Firm as a partner ... New York office. Mr. Lewis ... as well as other intellectual property and general litigation. ... Lewis represents both plaintiffs and defendants in a range ...
(Date:3/3/2015)... N.J. , March 3, 2015  Thingee Corporation, ... will be delivering a presentation entitled, "Technology Adoption: Making ... Thriving through Innovations and Technology ,  in ... March 11 to 13, 2015. Audiences looking to learn ... effectively will want to be in the audience for ...
Breaking Biology Technology:Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 3Thingee to present at 11th Annual Synergistix Users Conference 2
... BOSTON, Jan. 10, 2011 Entrega, Inc., a ... announced its formation by Enlight Biosciences, a Boston-based ... leading global pharmaceutical companies. As part of its ... spatially-directed proprietary drug delivery platform to create orally ...
... win. The professor of biotechnology at Delft University of ... in Rice University,s Matteo Pasquali. Together with ... (CNRS), the University of Bordeaux, France, and Vrije University, ... a long-standing controversy in the field of polymer dynamics: ...
... The Pittsburgh Life Sciences Greenhouse (PLSG), the organization ... growth programs to the region,s life sciences enterprises, issued ... John W. Manzetti announcing the first close of the ... Fund) at $5 million. The Accelerator Fund ...
Cached Biology Technology:New Oral Biologics Delivery Company, Entrega, Announces Strategic Partnership with Pharma 2New Oral Biologics Delivery Company, Entrega, Announces Strategic Partnership with Pharma 3Bendy tubes get around 2Bendy tubes get around 3Pittsburgh Life Sciences Greenhouse Announces the First Close of the PLSG Accelerator Fund LLC at $5 Million 2
PGC-1 (H-300)...
Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Anti-human CD48/BLAST-1, clone MEM102, Monoclonal Antibody...
Affinity Purified Anti-Human NP-1...
Biology Products: