Navigation Links
'Quadruple helix' DNA discovered in human cells
Date:1/20/2013

In 1953, Cambridge researchers Watson and Crick published a paper describing the interweaving 'double helix' DNA structure - the chemical code for all life.

Now, in the year of that scientific landmark's 60th Anniversary, Cambridge researchers have published a paper proving that four-stranded 'quadruple helix' DNA structures - known as G-quadruplexes - also exist within the human genome. They form in regions of DNA that are rich in the building block guanine, usually abbreviated to 'G'.

The findings mark the culmination of over 10 years investigation by scientists to show these complex structures in vivo - in living human cells - working from the hypothetical, through computational modelling to synthetic lab experiments and finally the identification in human cancer cells using fluorescent biomarkers.

The research, published today in Nature Chemistry and funded by Cancer Research UK, goes on to show clear links between concentrations of four-stranded quadruplexes and the process of DNA replication, which is pivotal to cell division and production.

By targeting quadruplexes with synthetic molecules that trap and contain these DNA structures - preventing cells from replicating their DNA and consequently blocking cell division - scientists believe it may be possible to halt the runaway cell proliferation at the root of cancer.

"We are seeing links between trapping the quadruplexes with molecules and the ability to stop cells dividing, which is hugely exciting," said Professor Shankar Balasubramanian from the University of Cambridge's Department of Chemistry and Cambridge Research Institute, whose group produced the research.

"The research indicates that quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells. For us, it strongly supports a new paradigm to be investigated - using these four-stranded structures as targets for personalised treatments in the future."

Physical
'/>"/>

Contact: Fred Lewsey
fred.lewsey@admin.cam.ac.uk
44-078-857-98680
University of Cambridge
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First description of a triple DNA helix in a vacuum
2. Doubling the information from the double helix
3. Unexpected crustacean diversity discovered in northern freshwater ecosystems
4. University of Alberta led research may have discovered how memories are encoded in our brains
5. Newly discovered foot points to a new kid on the hominin block
6. New immune defense enzyme discovered
7. New genetic mechanism of immune deficiency discovered
8. Housekeeping mechanism for brain stem cells discovered
9. Scientists have discovered genes that increase the risk of osteoporosis and fractures
10. New form of intellectual disability discovered
11. 24 new species of lizards discovered on Caribbean islands are close to extinction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
(Date:7/7/2015)... 30, 2015 Research ... addition of the "Capacitive Fingerprint Sensors Patent ... To this date, fingerprint sensing technology is the ... sensors are well developed. This patent landscape focuses ... The domain of capacitive fingerprint sensors is ...
(Date:7/2/2015)... Fingerprint Cards has received an order for its ... distributor World Peace Industrial Group (WPI), part of WPG Holdings. ... . Deliveries are planned to take place during Q3 ... manufacturers in Asia . The order value ... of approximately 2,200 MSEK for 2015. Jörgen Lantto, ...
Breaking Biology News(10 mins):Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... collective efforts to develop new drugs, the pharmaceuticals industry ... application of natural biological transformation processes. One of the ... cells in a bioreactor filled with a liquid culture ... regulations, the conditions inside the bioreactor need to be ...
... various Earth system science disciplines recently gathered to address ... in the future? Of course, possible answers to ... changing climatic conditions were to alter local vegetation, how ... Answering these questions with certainty would allow us to ...
... of BioScience, researchers present a sophisticated new ... ethanol on greenhouse gas emissions. The study, conducted by ... focuses on how mandated increases in production of the ... domestically and elsewhere. In response to the increased demand ...
Cached Biology News:Clean sampling from bioreactors 2Networking initiative to support interdisciplinary research 2Networking initiative to support interdisciplinary research 3More maize ethanol may boost greenhouse gas emissions 2
(Date:8/3/2015)... 2015  MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic and Dental sectors of healthcare, announced ... Annual Canaccord|Genuity Growth Conference in Boston, ... CEO, William C. Taylor , President and COO, ...
(Date:8/3/2015)... -- Merck KGaA, Darmstadt, Germany ,  a ... the healthcare, life science and performance materials sectors, announced ... and launch of promising new fullerene derivatives for the ... Germany , is pursuing many projects ... Novel derivatives: highly stable, easy to process and cost ...
(Date:8/3/2015)... 2015  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... life-threatening diseases, today announced that it will host its ... on Thursday, August 13, 2015 at 4:30 p.m. Eastern ... the release of fiscal 2016 first quarter results.  A ... two hours after the call at the Investor Relations ...
(Date:8/3/2015)... Aug. 3, 2015   Intrexon Corporation (NYSE: ... half and second quarter 2015 financial results after the ... The Company will host a conference call at 5:30 ... general business update. The conference call may ... (International), and asking to join the "Intrexon Corporation Call."  ...
Breaking Biology Technology:MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2
... Hollingsworth & Vose,Company (H&V), a leading ... introduced its HVision(TM) technology platform, a collaborative,process ... of,breakthrough products. "HVision will provide H&V ... a new generation of products that exceed ...
... Corporation (OTC,Bulletin Board: KDUS.OB) announced today financial results for the ... the third quarter of 2007 and for the same period,in ... $240,227, compared to,net income of $200,335 for the same period ... third quarter of 2007 and for the same period in,2006. ...
... Stock Exchange: EVT) Reported Today Results for,the First ... OXFORD, England, November 13 /PRNewswire-FirstCall/,-- Highlights: ... - Compelling results achieved in two proof-of-concept ... 201 - Sale of the Chemical Development ...
Cached Biology Technology:H&V Introduces HVision Technology Platform to Accelerate Development of Breakthrough Products 2Cadus Reports Third Quarter 2007 Results 2Cadus Reports Third Quarter 2007 Results 3Cadus Reports Third Quarter 2007 Results 4Evotec Reports Third Quarter 2007 Results 2Evotec Reports Third Quarter 2007 Results 3Evotec Reports Third Quarter 2007 Results 4Evotec Reports Third Quarter 2007 Results 5Evotec Reports Third Quarter 2007 Results 6Evotec Reports Third Quarter 2007 Results 7Evotec Reports Third Quarter 2007 Results 8
... is a recombinant protein that has been shown ... the preparation of cDNA by reverse transcription, in ... synthesis. RNA Safe Inhibitor tightly binds RNases in ... of eukaryotic RNases such as RNase A, RNase ...
...
... RNase Inhibitor (Ribonuclease inhibitor) ... enzyme used to inhibit RNase ... DNase or endonuclease activity. , ... degradation of RNA template ...
...
Biology Products: