Troy, N.Y. - Engineers at Rensselaer Polytechnic Institute have developed tools to help solve two of the main problems slowing the progress of stem cell research how to quickly test stem cell response to different drugs or genes, and how to create a large supply of healthy, viable stem cells to study from only a few available cells.
The researchers have created methods to study millions of stems cells on devices the size of a standard microscope slide. The techniques enable thousands of individual stem cell experiments to be carried out quickly and in parallel on one small device.
Rensselaer is quickly establishing itself as leader in the development of stem cell technology that hastens the speed and accuracy of stem cell research, Provost Robert Palazzo said. Our scientists and engineers are filling a vital niche in the global scientific effort to develop medical therapies using stem cells. Tools like these, which enable high-throughput study of stem cells, will quickly advance stem cell research in medical labs around the world.
The two groups of researchers used microarrays to develop miniaturized stem cell laboratories. With this technique researchers can perform high-throughput analysis of the material or cells on a single slide, analyzing tens of thousands of samples in one experiment. Each of the teams developed separate specialized microarray platforms.
Helping Develop Stem Cell Drugs
A team led by Jonathan Dordick, the Howard P. Isermann Professor of Chemical and Biological Engineering, and visiting doctoral student Tiago Fernandez and Professor Joaquim M.S. Cabral from the Instituto Superior Tchinco-Lisbon in Portugal developed a platform that will enhance the speed of drug discovery by revealing how different molecules help or hinder stem cell function. Their research was presented at the 234th American Chemical Society (ACS) National Meeting in Boston on Aug. 19.
The platform will serv
|Contact: Gabrielle DeMarco|
Rensselaer Polytechnic Institute