Navigation Links
Purifying proteins: Rensselaer researchers use NMR to improve drug development
Date:9/29/2010

Troy, N.Y. The purification of drug components is a large hurdle facing modern drug development. This is particularly true of drugs that utilize proteins, which are notoriously difficult to separate from other potentially deadly impurities. Scientists within the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute are using nuclear magnetic resonance (NMR) to understand and improve an important protein purification process.

"We hope to use our insights to help those in the industry develop improved processes to provide much less expensive drugs and dramatically reduce healthcare costs," said paper author and William Weightman Walker Professor of Polymer Engineering Steven Cramer of Rensselaer.

His team's findings are published in the Sept. 2 online early edition of the journal Proceedings of the National Academy of Sciences (PNAS ) in a paper titled "Evaluation of protein absorption and preferred binding regions in multimodal chromatography using NMR." The research was funded by the National Science Foundation (NSF).

The process of multimodal chromatography has recently generated significant interest in the pharmaceutical industry. At its most basic, this process separates proteins from their surrounding materials, such as DNA and other proteins. The process works by encouraging the desired protein to stick to a material that contains a ligand, a type of molecular glue. Each ligand is only attracted to certain parts of certain proteins. Having been separated from the mixture, the specific protein can now be obtained in purer form, facilitating its eventual use as a biotherapeutic.

The more selective the ligand is at binding to a specific protein, the more efficient the process is, and the less additional steps are required to produce the final drug. This results in reduced costs for the production of the drug. But despite its widespread use and benefits, there is very li
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New lab manual focuses on essential methods for purifying and characterizing proteins
2. Membrane-coat proteins: Bacteria have them too
3. Rensselaer professor uncovers mysterious workings of cholera bacteria
4. Left or right? Early clues to soccer penalty kicks revealed at Rensselaer Polytechnic Institute
5. Rensselaer Polytechnic Institute professor Peter M. Tessier named Pew Scholar
6. Rensselaer Polytechnic Institute professor Patrick Underhill receives NSF CAREER award
7. Rensselaer Polytechnic Institute wins $2.45 million grant to support stem cell research
8. Rensselaer researchers to send bacteria into orbit aboard space shuttle Atlantis
9. Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals
10. Rensselaer receives more than $2 million from New York State to fund stem cell research
11. Trustee makes donation to start new solar energy research center at Rensselaer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purifying proteins: Rensselaer researchers use NMR to improve drug development
(Date:2/11/2015)... , February 11, 2015 ... research report "Access Control Market by Product (Cards and ... Residential, Military and Defense, Government, Industrial, Healthcare, Education) and ... published by MarketsandMarkets, the Access Control Market ... 2020, growing at a CAGR of 10.6% ...
(Date:2/5/2015)... , 5. Februar 2015 ... spezialisiertes Logistikunternehmen und hat eine neue Marketingkampagne ... Logistikfirma (Clinical Logistics Organization – CLO) der ... Kampagne lautet First , mit Schwerpunkt ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 Logo ...
(Date:2/5/2015)... Conn. , Jan. 26, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... new corporate website ( http://www.nxt-id.com/ ) as part of ... smart wallet. The Company launched its new consumer website ... Gino Pereira , CEO of NXT-ID said, "Our new ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3
... who has watched crime dramas on TV knows that ... from evidence gathered at a crime scene, establish a ... has been wrongly jailed. A lesser known but rapidly ... paternal ancestrya process known as genetic genealogy. The laboratories ...
... symptoms until it has spread to other organs, when it ... great promise for extending survival during later disease stages, but ... of the first discoveries of its kind, UC Davis Cancer ... own repair mechanism and, in so doing, help make chemotherapy ...
... Texas Health Science Center at Houston (UTHSC-Houston) were honored ... at the 2008 American Heart Association,s Scientific Sessions in ... killer. UT faculty members recognized were: Nobel Laureate ... Foundation Institute of Molecular Medicine for the Prevention of ...
Cached Biology News:NIST guides genetic genealogy labs toward improved accuracy 2UC Davis discovery offers hope for treating kidney cancer 2UT faculty members win American Heart Association awards for advancing research 2UT faculty members win American Heart Association awards for advancing research 3
(Date:2/27/2015)... BOSTON , Feb. 27, 2015   PureTech ... identifying, inventing and commercializing disruptive products and technologies in ... Christopher Viehbacher , former CEO and Member of the ... Directors.  "It,s has been a pleasure ... very excited that we will be working together more ...
(Date:2/26/2015)...   Synageva BioPharma Corp. (NASDAQ: ... products for rare disorders, today reported 2014 full ... key objectives, and financial guidance.  Synageva,s management team ... p.m. EST to review the financial results and ... today,s call by telephone, please dial (877) 445-4603 ...
(Date:2/26/2015)... 2015 On behalf of biotech client ... Wilentz, Goldman & Spitzer, P.A. (Wilentz) secured ... against Genewiz Inc. in excess of $10 million. The ... trade secrets, and that it improperly hired one or ... order denying motions for judgment notwithstanding the verdict, a ...
(Date:2/26/2015)... Already well respected for accuracy, HEIDENHAIN ... its Length Gauge offerings with new variants of its ... Specifically, HEIDENHAIN’s pencil probe-style SPECTO length gauge series now ... new 1Vpp, 12mm stroke length variants of the SPECTO ... a variant with a weak spring, 0.4N of gauging ...
Breaking Biology Technology:Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Accuracy and Versatile Gauging Go Hand in Hand at HEIDENHAIN 2
... a failed terrorist attack in 2006, plane passengers have not ... airports, leaving some parched at the airport and others having ... in Germany is paving the way to eliminate this necessary ... in IOP Publishing,s Superconductor Science and Technology explains ...
... This release is available in German . ... the electromagnetic character of radio waves by Heinrich Hertz, wireless ... are applied to transmit more data within shorter periods of ... also be used for radio transmis-sion. So far, however, manufacture ...
... Inc. (TSX: ONC, NASDAQ: ONCY ) ("Oncolytics") announced ... Canadian Biosciences Corp. (BCBC), a privately held biotechnology company ... of a variety of conditions, including cancer. , Oncolytics ... BCBC in exchange for 200,000 common shares of Oncolytics. ...
Cached Biology Technology:0.2 second test for explosive liquids 2Smallest nanoantennas for high-speed data networks 2Smallest nanoantennas for high-speed data networks 3Oncolytics Biotech(R) Inc. Announces Investment in Private Biotechnology Company 2
... Error-free cloning of BAC (100+kb), fosmid (40kb), ... insert stability than any othe BAC vector. ... high yields and easy recombinant DNA purification. ... transcription-free (pSMART VC) vectors for the highest ...
TACS Apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
SHEEP ANTI HUMAN ESTRONE...
RABBIT ANTI HUMAN APP (KP1 DOMAIN) Immunogen: Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP....
Biology Products: