Navigation Links
Purifying proteins: Rensselaer researchers use NMR to improve drug development

Troy, N.Y. The purification of drug components is a large hurdle facing modern drug development. This is particularly true of drugs that utilize proteins, which are notoriously difficult to separate from other potentially deadly impurities. Scientists within the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute are using nuclear magnetic resonance (NMR) to understand and improve an important protein purification process.

"We hope to use our insights to help those in the industry develop improved processes to provide much less expensive drugs and dramatically reduce healthcare costs," said paper author and William Weightman Walker Professor of Polymer Engineering Steven Cramer of Rensselaer.

His team's findings are published in the Sept. 2 online early edition of the journal Proceedings of the National Academy of Sciences (PNAS ) in a paper titled "Evaluation of protein absorption and preferred binding regions in multimodal chromatography using NMR." The research was funded by the National Science Foundation (NSF).

The process of multimodal chromatography has recently generated significant interest in the pharmaceutical industry. At its most basic, this process separates proteins from their surrounding materials, such as DNA and other proteins. The process works by encouraging the desired protein to stick to a material that contains a ligand, a type of molecular glue. Each ligand is only attracted to certain parts of certain proteins. Having been separated from the mixture, the specific protein can now be obtained in purer form, facilitating its eventual use as a biotherapeutic.

The more selective the ligand is at binding to a specific protein, the more efficient the process is, and the less additional steps are required to produce the final drug. This results in reduced costs for the production of the drug. But despite its widespread use and benefits, there is very li

Contact: Gabrielle DeMarco
Rensselaer Polytechnic Institute

Page: 1 2 3

Related biology news :

1. New lab manual focuses on essential methods for purifying and characterizing proteins
2. Membrane-coat proteins: Bacteria have them too
3. Rensselaer professor uncovers mysterious workings of cholera bacteria
4. Left or right? Early clues to soccer penalty kicks revealed at Rensselaer Polytechnic Institute
5. Rensselaer Polytechnic Institute professor Peter M. Tessier named Pew Scholar
6. Rensselaer Polytechnic Institute professor Patrick Underhill receives NSF CAREER award
7. Rensselaer Polytechnic Institute wins $2.45 million grant to support stem cell research
8. Rensselaer researchers to send bacteria into orbit aboard space shuttle Atlantis
9. Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals
10. Rensselaer receives more than $2 million from New York State to fund stem cell research
11. Trustee makes donation to start new solar energy research center at Rensselaer
Post Your Comments:
Related Image:
Purifying proteins: Rensselaer researchers use NMR to improve drug development
(Date:9/28/2015)... 28, 2015 The global ... USD 12.03 billion by 2020, growing at a CAGR ... as Backside Illumination (BSI) technique to improve picture quality ... period.      (Logo: , ... to reduce loss and, thus, reduce the noise interference ...
(Date:9/26/2015)... 26th, 2015  Results of a TactioRPM pilot ... today at the Stanford Medicine X Conference. In ... Dashboards, Connected Health Devices and Pharmacogenomics", Roger ... will explain how senior patients equipped with connected ... pharmacist via the TactioRPM remote patient monitoring platform ...
(Date:9/10/2015)... This report provides detailed descriptions of the sensor types ... types that will dominate in the future. Many product ... technology hype curve in the last five years before ... all of them is the prominence of sensor options ... Sensors collect data about the physical and chemical properties ...
Breaking Biology News(10 mins):Image Sensors Market Size to Reach $12.03 Billion By 2020: Grand View Research, Inc. 2Image Sensors Market Size to Reach $12.03 Billion By 2020: Grand View Research, Inc. 3Image Sensors Market Size to Reach $12.03 Billion By 2020: Grand View Research, Inc. 4Image Sensors Market Size to Reach $12.03 Billion By 2020: Grand View Research, Inc. 5Results of TactioRPM Pilot in a Senior Home Unveiled at Stanford Med X Conference 2Results of TactioRPM Pilot in a Senior Home Unveiled at Stanford Med X Conference 3Wearable Sensors 2015-2025: Market Forecasts, Technologies, Players 2
... limited by the seasons, particularly in colder climates ... researchers and fruit breeders, newly developed varieties are ... produce fruit during the offseasonresulting in economic bonuses ... the new varieties of blackberry called "primocane-fruiting", which ...
... The roe of hake, lumpsucker and salmon is the best dietary ... researchers at the University of Almera (UAL). The scientists analysed the ... these contained high levels of these fatty acids, which are essential ... precise understanding of the nutritional potential of the roe of marine ...
... , SAN DIEGO, ... has converted part of an existing building (Keen Hall), including ... cell core facility for the University of California, Riverside. ... , "A key project element was to ensure that although ...
Cached Biology News:New management methods extend blackberry season 2Roe of marine animals is best natural source of omega-3 2Kornberg Associates | Architects Completes UC Riverside Stem Cell Core Facility Project 2
(Date:10/1/2015)... WORCESTER, Mass. and TORONTO ... ( ) (OTCQB: GNBT) today announced the issuance ... for medicinal purposes and the joint venture between Generex ... design and development of products for the delivery of ... the buccal mucosa (the inner lining of the mouth). ...
(Date:10/1/2015)... 2015  xG Health Solutions, a leading healthcare ... new platform for communication and collaboration with healthcare ... and health plans improve the quality and efficiency ... solutions, products and educational resources. ... clinicians, we know the process of re-engineering care ...
(Date:10/1/2015)... 1, 2015 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug ... in the upcoming Aegis Growth Conference, taking place October ...  Josh Hexter, COO of Oramed, will present a corporate ... Details:   2015 Aegis Growth Conference ...
(Date:10/1/2015)... (PRWEB) , ... October 01, 2015 , ... Mark Seymour, of Radiant Hearth in Potsdam, ... and built a Tulikivi masonry heater for the Mac Kentley family in northern New York. ... that the family's boiler did. One fire is normally enough to keep the home comfortable ...
Breaking Biology Technology:Generex Announces Issuance of Buccal Cannabis White Paper 2Generex Announces Issuance of Buccal Cannabis White Paper 3Generex Announces Issuance of Buccal Cannabis White Paper 4xG Health Solutions Launches New Platform for Hospitals, Clinics and Health Plans 2Oramed to Present at the Aegis Capital Growth Conference 2Oramed to Present at the Aegis Capital Growth Conference 3The Masonry Heater Association of North America Receives News About A New York Couple Who Saved Considerable Money Heating Their Home With A Wood Fired Masonry Heater 2
... 15 Congressional Quarterly presents a 360-degree look at ... versions of biotech drugs. This CQ Forum will include ... and leading researchers regarding the complex structures of biologics ... the availability of these products save money for consumers? ...
... Pharmaceuticals, Inc. (Nasdaq: HEPH ), a leader in ... based on endogenous adrenal steroid hormones, today announced the board ... and CEO of Hollis-Eden Pharmaceuticals, Inc. Dr. Frincke was ... , Dr. Frincke joined Hollis-Eden as Vice President, Research and ...
... , HONOLULU, June 15 Nanopoint Inc., an ... products, today announced that effective immediately its cellTRAY ... to the European marketplace. Nanopoint,s cellTRAY Imaging and ... of applications including drug discovery, assisted reproductive technology ...
Cached Biology Technology:Hollis-Eden Pharmaceuticals Announces Appointment of Dr. James M. Frincke President and CEO 2Hollis-Eden Pharmaceuticals Announces Appointment of Dr. James M. Frincke President and CEO 3Nanopoint Applies CE Mark to Its cellTRAY(R) Imaging and Microfluidics Systems 2