Navigation Links
Purdue team creates 'engineered organ' model for breast cancer research
Date:1/24/2011

p>

Lelièvre, whose group is one of the few in the world able to successfully grow the complicated cells that line the mammary ducts, coaxed the cells to grow within the mold and behave as they would within a real human breast.

"The cells within the breast ductal system have a very specific organization that has proven difficult to obtain in a laboratory," Lelièvre said. "The cells have different sides, and one side must face the wall of the duct and the other must face the inner channel. Reproducing this behavior is very challenging, and it had never been achieved on an artificial structure before."

The team coated the mold in a protein-based substance called laminin 111 as a foundation for the cells that allows them to attach to the mold and behave as they would inside the body, Lelièvre said.

Because injecting the delicate cells into the finished channels of the mold caused too much damage, the team created a removable top for the channels.

"The design of the U-shaped channels and top was necessary for us to be able to successfully apply the cells, but it also allows us to make changes quickly and easily for different tests," Lelièvre said. "We can easily introduce changes among the cells or insert a few tumor cells to test the abilities of the nanoparticles to recognize them. The design also makes it very easy to evaluate the results as the entire model fits under a microscope."

A paper detailing the team's work, which was funded by the U.S. Department of Defense, is published in the current issue of Integrative Biology. In addition to Lelièvre and Leary, co-authors include graduate student Meggie Grafton, research associate Lei Wang and postdoctoral researcher Pierre-Alexandre Vidi.

The team has demonstrated that nanoparticles can be moved within the bare channels of the mold filled with fluid, but has not yet moved nanoparticles through the finished model lined
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NASA, Purdue study offers recipe for global warming-free industrial materials
2. Protein can help cells or cause cancer, Purdue researcher finds
3. Purdue study finds dairy better for bones than calcium carbonate
4. Purdue study suggests warmer temperatures could lead to a boom in corn pests
5. Purdue researcher invents molecule that stops SARS
6. Scripps Research team creates new synthetic compound with HIV-fighting promise
7. Caltech-led team creates damage-tolerant metallic glass
8. Team creates novel vaccine that produces strong immunity against cocaine high
9. CCNY-led interdisciplinary team recreates colonial hydrology
10. Salk Institute creates Renato Dulbecco Chair in Genomics and Roger Guillemin Chair in Neuroscience
11. Researchers find that one type of stem cell creates a niche for another type in bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purdue team creates 'engineered organ' model for breast cancer research
(Date:11/10/2014)... shelves in early 2010, and people have used them ... be tossed into a washing machine without ever having ... though, has come with risks for young children. , ... found that from 2012 through 2013, U.S. poison control ... years of age swallowing, inhaling, or otherwise being exposed ...
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
(Date:11/5/2014)... in the UTSA College of Sciences, is one ... receive a two-year $300,00 National Science Foundation (NSF) ... funding supports President Obama,s BRAIN Initiative, a federal ... that will demystify complex brain processes. , ... broken into the interactions of multiple components, each ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... Scientists at the Genome Institute of Singapore (GIS), ... Technology and Research (A*STAR), and their colleagues from the ... Medical School and Princeton University have recently discovered that ... ago have changed the way genes get turned on ...
... the brain by the hunger-signaling hormone ghrelin, researchers say. ... the pharmacologic control of cholesterol levels. The ... the University of Cincinnati (UC) endocrinology division, appears online ... Nature Neuroscience . "We have long thought ...
... from biomass as a raw material many more things than ... Mara Gonzlez looked for the most appropriate types of biomass ... for refining them. Her aim was to obtain the most ... fossil fuels in the future. The PhD thesis was defended ...
Cached Biology News:Scientists discover ancient viral invasion that shaped human genome 2Scientists discover ancient viral invasion that shaped human genome 3'Remote control' for cholesterol regulation discovered in brain 2Ph.D. thesis opens doors to obtaining chemical products and materials using biomass as raw material 2Ph.D. thesis opens doors to obtaining chemical products and materials using biomass as raw material 3
(Date:11/17/2014)... PRINCETON, N.J. , Nov. 17, 2014 /PRNewswire/ ... Company), a late-stage biopharmaceutical company developing products that ... inflammation, oncology and biodefense, announced today the formation ... medical/clinical strategic guidance to the Company as it ... (synthetic hypericin) for the treatment of cutaneous T-cell ...
(Date:11/15/2014)... 2014 Collaborative Consulting, a privately held, ... one of the Boston Globe’s “Top Places to Work ... in Massachusetts to receive the honor. , The Boston ... care of their most valuable resource: the people who ... and are based on an array of criteria, including ...
(Date:11/15/2014)... The International Society for ... the society’s Governing Board has grown with the ... scientific officer and Dr. Charles Simonton, divisional vice ... Mr. Rowe and Dr. Simonton are both ... , Dr. Nabil Dib, ISCTR President stated, ...
(Date:11/15/2014)... The "Operating Room Management Market by Product (Data ... operating room Scheduling), by Component (Software, Services), by ... 2019.” defines and segments the operating room management ... by product, such as data management, anesthesia, surgical ... volumes of operating room management market by applications ...
Breaking Biology Technology:Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 2Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 3Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 4Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 5Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 6Collaborative Consulting Honored with Boston Globe Top Places to Work 2014 2International Society for Cardiovascular Translational Research Governing Board Adds Medical Industry Leaders 2Operating Room Management Market Worth $4,551.1 Million by 2019 - New Report by MarketsandMarkets 2Operating Room Management Market Worth $4,551.1 Million by 2019 - New Report by MarketsandMarkets 3Operating Room Management Market Worth $4,551.1 Million by 2019 - New Report by MarketsandMarkets 4
... Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) announced ... during the 4th Annual BIO Investor Forum,on Thursday, ... The presentation,will be webcast from The Palace Hotel, ... Relations tab at http://www.alexza.com or, http://www.corporate-ir.net/ireye/confLobby.zhtml?ticker=ALXA&item_id=16576 ...
... Dr. Brad Thompson, President,and CEO of Oncolytics Biotech ... overview of the Company at the 15th annual ... 9 at 9 a.m. The conference,will be held ... October 7-9,2007. About Oncolytics Biotech Inc. ...
... a special eye for the,details hidden from casual view, ... Aspinall. Photographs of architectural details from beaches,to buildings and ... The,collection includes images from seven different countries., Well-known ... of Genzyme Genetics, is also a talented artist whose ...
Cached Biology Technology:The 4th Annual BIO Investor Forum to Webcast Alexza's Corporate Presentation 2Media Advisory - Oncolytics Biotech Inc. to Present at BioPartnering Europe 2An Uncommon Eye: Photography Exhibit by Biotechnology Executive at BHCC Gallery 2
... Cell Dissociation Buffers are membrane-filtered isotonic ... chelating agents and cell-conditioning agents in ... salt solution or Ca2+- and ... of mammalian cells from support substrates ...
Request Info...
Mouse monoclonal [7A6] to NFAT2 ( Abpromise for all tested applications). entrezGeneID: 4772 SwissProtID: O95644...
Attoglow Western Blot Enhancing Kit contains Millennium Enhancer which can significantly boost Western blot signals, and is compatible with other enhancing mechanisms to achieve multiplied enhancing ...
Biology Products: