Navigation Links
Purdue team creates 'engineered organ' model for breast cancer research
Date:1/24/2011

WEST LAFAYETTE, Ind. - Purdue University researchers have reproduced portions of the female breast in a tiny slide-sized model dubbed "breast on-a-chip" that will be used to test nanomedical approaches for the detection and treatment of breast cancer.

The model mimics the branching mammary duct system, where most breast cancers begin, and will serve as an "engineered organ" to study the use of nanoparticles to detect and target tumor cells within the ducts.

Sophie Lelièvre, associate professor of basic medical sciences in the School of Veterinary Medicine, and James Leary, SVM Professor of Nanomedicine and professor of basic medical sciences in the School of Veterinary Medicine and professor of biomedical engineering in the Weldon School of Biomedical Engineering, led the team.

"Breast cancer is the most common cancer in women in most countries, and in the U.S. alone nearly 40,000 women lost their lives to it this past year," said Lelièvre, who is associate director of discovery groups in the Purdue Center for Cancer Research and a leader of the international breast cancer and nutrition project in the Oncological Sciences Center. "We've known that the best way to detect this cancer early and treat it effectively would be to get inside the mammary ducts to evaluate and treat the cells directly, and this is the first step in that direction."

Lelièvre and Leary hope eventually to be able to introduce magnetic nanoparticles through openings in the nipple, use a magnetic field to guide them through the ducts where they would attach to cancer cells and then reverse the magnetic field to retract any excess nanoparticles.

The nanoparticles could carry contrast agents to improve mammography, fluorescent markers to guide surgeons or anticancer agents to treat the cancer, Leary said.

"Nanoparticles can be designed to latch on to cancer cells and illuminate them, decreasing the size of a tumor th
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NASA, Purdue study offers recipe for global warming-free industrial materials
2. Protein can help cells or cause cancer, Purdue researcher finds
3. Purdue study finds dairy better for bones than calcium carbonate
4. Purdue study suggests warmer temperatures could lead to a boom in corn pests
5. Purdue researcher invents molecule that stops SARS
6. Scripps Research team creates new synthetic compound with HIV-fighting promise
7. Caltech-led team creates damage-tolerant metallic glass
8. Team creates novel vaccine that produces strong immunity against cocaine high
9. CCNY-led interdisciplinary team recreates colonial hydrology
10. Salk Institute creates Renato Dulbecco Chair in Genomics and Roger Guillemin Chair in Neuroscience
11. Researchers find that one type of stem cell creates a niche for another type in bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purdue team creates 'engineered organ' model for breast cancer research
(Date:7/10/2014)... , July 2, 2014  Unisys Corporation,s (NYSE: ... , Unisys Nederland N.V., today announced that it has been ... implement and manage a new Basic Provision Biometrics solution for ... Unisys won the contract with a solution based on ... software. The term of the contract is up to seven ...
(Date:7/10/2014)... 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... Gino Pereira was interviewed on July 1 st ... Tampa Florida . Mr. Pereira discusses the company,s next ... and how the Wocket™ aims to replace a traditional ... Cedric Harris tells Gino he has never heard ...
(Date:7/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h7h8lq/gesture ) ... Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, ... report to their offering ... Touch-Less Sensing Market to Grow Exponentially. Touch-less sensing ... the companies were unable to leverage this technology ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... western Pacific Ocean may be losing their last foothold ... a paper published today in the scientific journal ... Researchers from the State University of Papua Indonesia, ... World Wildlife Fund Indonesia released a report today documenting ...
... articles cover wind erosion and sediment traps in the Qaidam ... Forest, USA; a forearc sliver in Costa Rica; Quebec,s St. ... Ries Crater Lake, Germany; bending and buckling mountain belts; a ... and the evolution of the ancient Montana landscape. ...
... The Association for Research in Vision and Ophthalmology 2013 ... including two Nobel laureates, during the organization,s five-day conference, ... this year, the ARVO/Alcon Keynote Series will include Oliver ... DPhil. Smithies, of the University of North Carolina ...
Cached Biology News:New study shows continued decline in the last remaining stronghold for leatherback sea turtles 2Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 2Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 3Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 4Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 5Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 6Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 7Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 8Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 93 distinguished keynote speakers to present during ARVO 2013 Annual Meeting 2
(Date:7/10/2014)... Women in the West African ... additional family planning option. Sayana® Press has the ... levels of the health system and in communities ... used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with the BD ... first of four African countries expected to begin ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, and ... purchased a DNA test to unravel the ... a lifetime of memories, sharing, and closeness. In fact, ... genuinely brought the family closer together. , Recently, ... history and prior to taking the genetic ancestry ...
(Date:7/10/2014)... CROWN POINT, Ind. , July 10, ... recently expanded its use of capnography for ... a growing group of healthcare leaders in ... Capnography measures how effectively patients are breathing ... respiratory depression occurs. By measuring the amount ...
(Date:7/10/2014)... OAKS, Calif., July 10, 2014   Ceres, Inc ... and seed company, announced today financial results for the ... update on its business. Ceres reported that ... in product performance this growing season in Brazil, which ... affected the company,s sorghum evaluation areas for part of ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... $0.64 - $0.67 from Prior Range of ... $0.47 - $0.53,Reaffirms Adjusted EPS Guidance of $0.90 - $1.10 for 2009 and ... ... its financial results for the three and nine months ended,Sept. 30, 2008., Financial Highlights, ...
... Vanda Pharmaceuticals,Inc. (Nasdaq: VNDA ), a biopharmaceutical ... product candidates for central,nervous system disorders, today announced ... September 30, 2008., Vanda reported research and ... of $3.8 million, compared to $5.5 million in ...
... GmbH, the leading,European manufacturer of cardiac occlusion devices, today ... Hague, Holland, against AGA Medical Inc.,regarding non-infringement of the ... patent court in The Hague stated that the disputed ... 0808138 (equivalent of,German patent DE 695 34 505.2) held ...
Cached Biology Technology:Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 2Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 3Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 4Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 5Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 6Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 7Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 8Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 9Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 10Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 11Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 12Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 13Mylan Reports Adjusted Diluted EPS of $0.23 for the Quarter Ended Sept. 30, 2008 14Vanda Pharmaceuticals Reports Third Quarter 2008 Results 2Vanda Pharmaceuticals Reports Third Quarter 2008 Results 3Vanda Pharmaceuticals Reports Third Quarter 2008 Results 4Vanda Pharmaceuticals Reports Third Quarter 2008 Results 5Vanda Pharmaceuticals Reports Third Quarter 2008 Results 6Vanda Pharmaceuticals Reports Third Quarter 2008 Results 7Vanda Pharmaceuticals Reports Third Quarter 2008 Results 8Vanda Pharmaceuticals Reports Third Quarter 2008 Results 9Vanda Pharmaceuticals Reports Third Quarter 2008 Results 10Occlutech Obtains Favourable Court Ruling in Patent Litigation in The Hague Against AGA Medical 2
... Well Plate Sterile with ... range of 384-well plates ... screening and research. These ... and are suitable for ...
Request Info...
... to Cytokeratin 5 / 6 Cytokeratin ... weight, basic type of cytokeratin expressed in ... layers of stratified epithelia as well as ... cells and mesothelioma. Cytokeratin 6 (56 kD) ...
Bovine Coronary Artery Endothelial Cells (BCAEC) (>500,000 cells)...
Biology Products: