Navigation Links
Purdue researchers reveal role of protein mutation in Parkinson's disease
Date:2/21/2012

WEST LAFAYETTE, Ind. - Purdue University researchers revealed how a mutation in a protein shuts down a protective function needed to prevent the death of neurons in Parkinson's disease, possibly opening the door to new drug strategies to treat the disorder.

Fred Regnier, the J.H. Law Distinguished Professor of Chemistry, and Jean-Christophe Rochet, an associate professor of medicinal chemistry and molecular pharmacology, led the team that discovered how the protein DJ-1, which plays a significant role in protecting neurons from damage, is shut down by a subtle mutation.

A substitution in one link of the chain of amino acids that makes up the protein renders it unable to be activated to protect neurons from the build up of protein "aggregates," or "clumps," that lead to cell death in those with Parkinson's disease.

"The saying that you are only as strong as your weakest link appears to hold true in the case of the chain of amino acids that make up a protein," Regnier said. "The magnitude of the effect of this subtle change is surprising. It can make the difference between having a disease and being healthy."

According to the Parkinson's Disease Foundation, an estimated 7 million to 10 million people worldwide are living with the disease, which is a neurodegenerative disorder that causes muscular rigidity, slowness of movement, poor balance and tremors. The death of neurons in a region of the brain called the substantia nigra cause the symptoms.

The findings of the Purdue-led study could potentially lead to new Parkinson's treatments, Rochet said.

"The current methods of treatment are to add back what the lost cells used to produce, similar to hormone replacement therapies," he said. "Understanding this error in a key protein could help researchers find a way to prevent cell death in the first place. Perhaps a compound could be found that could correct the problem and resurrect the protective function of the
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Purdue researcher invents molecule that stops SARS
2. Purdue study suggests warmer temperatures could lead to a boom in corn pests
3. Purdue study finds dairy better for bones than calcium carbonate
4. Protein can help cells or cause cancer, Purdue researcher finds
5. NASA, Purdue study offers recipe for global warming-free industrial materials
6. Purdue team creates engineered organ model for breast cancer research
7. Purdue startup hopes to change the way we test cancer drugs
8. Purdue-led team studies Earths recovery from prehistoric global warming
9. Purdue biologists identify new strategy used by bacteria during infection
10. Purdue technology used in first fluorescence-guided ovarian cancer surgery
11. Purdue scientists reveal how bacteria build homes inside healthy cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purdue researchers reveal role of protein mutation in Parkinson's disease
(Date:3/11/2015)... BOSTON , March 11, 2015   ... of its platform to scientifically measure and harness ... characteristics to real-time biometrics and objective measurements of ... of music at scale in large populations. It ... scientists, technologists and clinicians perform rigorous studies and ...
(Date:3/10/2015)... March 10, 2015 Transforming How ... "Personalized Medicine in Human Space Flight" by ... J. Goodwin , Ph.D. was recently featured by Springer ... two years. Specifically, "Personalized Medicine in Human ... papers published in 2013 and 2014 from Springer in ...
(Date:3/10/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ... biometric authentication company focused on the growing mobile ... has been named the "Number One Best Tech ... Rethink Modern ( http://www.rethinkmodern.com/ ) is a web ... and lifestyle that have a unique function or design.  ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... robot named Eliza to conquer the tyranny of distance and ... , Eliza, who began work at Mt Isa Hospital this ... Health ?a world leader in telemedicine research. , ... sick children for video-link consultations with Brisbane specialists, greatly reducing ...
... are using genetic studies and natural chemicals, such as ... and early molecular interactions can lead to cancer, and ... off a variety of cancers. The latest studies with ... American Association for Cancer Research's Frontiers in Cancer Prevention ...
... for costly insulin injections for diabetics, regenerating heart muscle ... engineering immune cells top a list of 10 potential ... the new world of regenerative medicine, according to a ... of Science (PLoS) Medicine. , Conducted by University of ...
Cached Biology News:Telemedicine robots help improve health 2Plant-derived molecules, genetic manipulation point to future chemoprevention methods 2Plant-derived molecules, genetic manipulation point to future chemoprevention methods 3Plant-derived molecules, genetic manipulation point to future chemoprevention methods 4Plant-derived molecules, genetic manipulation point to future chemoprevention methods 5Replacing insulin is top-ranked breakthrough foreseen for health in developing world 2Replacing insulin is top-ranked breakthrough foreseen for health in developing world 3Replacing insulin is top-ranked breakthrough foreseen for health in developing world 4Replacing insulin is top-ranked breakthrough foreseen for health in developing world 5Replacing insulin is top-ranked breakthrough foreseen for health in developing world 6
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
(Date:3/26/2015)... ReliantHeart, Inc., an innovative supplier of advanced ... precision transit-time flow measurement solutions, are collaborating on a ... of the HeartAssist5® Left Ventricular Assist Device ... mobility and peace of mind. , The Transonic ... draw 1/6th of the power required by earlier flow ...
(Date:3/25/2015)... market is one of the most attractive in the ... plus a growing economy and increasing government investment in ... The Russian market is set to grow at twice ... estimates around 10-15% annually reaching an approximate market value ... Cross Green Cross provides total healthcare solutions ...
(Date:3/25/2015)... March 25, 2015 The surging ... smartphones have fuelled social media growth, with over ... engaged in social networking. Insurance companies are making ... with clients and promote a diversity of their ... are increasingly exploiting social networking services as part ...
Breaking Biology Technology:BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3
... Calif., Oct. 3 Alexza,Pharmaceuticals, Inc. (Nasdaq: ... be webcast live during the 4th Annual BIO ... p.m. Eastern Time. The presentation,will be webcast from ... accessed,under the Investor Relations tab at http://www.alexza.com ...
... enhance equity stake in Zenotech Laboratories to 45%, ... Zenotech Laboratories Limited (Zenotech) today announced the,signing of Definitive ... from its current 7% to 45% at a price ... This involves: (a) Purchase of shares from the ...
... Marshall Edwards,Inc. (Nasdaq: MSHL ) will present ... Palace Hotel on Thursday, October 11, 2007 at 12:00 ... Inc. (Nasdaq: MSHL ) is a specialist oncology ... derive from a flavonoid technology platform which has generated ...
Cached Biology Technology:The 4th Annual BIO Investor Forum to Webcast Alexza's Corporate Presentation 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3Marshall Edwards, Inc. to Present at BIO Investor Forum 2007 2Marshall Edwards, Inc. to Present at BIO Investor Forum 2007 3
...
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
Supplemental reagent for annexin V assay....
Large-fragment, single-stranded carrier DNA of the highest quality, perfectly suited for all types of yeast transformation....
Biology Products: