Navigation Links
Purdue researchers obtain a snapshot clarifying how materials enter cells
Date:11/30/2007

WEST LAFAYETTE, Ind. - A group of Purdue University researchers has captured a key step in the metabolic process that allows materials, such as nutrients and drug treatments, to move in and out of cells.

A research team led by Jue Chen, an associate professor of biological sciences, obtained a snapshot of the tiny protein gate complex that opens and closes pathways through the protective cellular membrane. The gates, operated by small protein machines that push them open and closed, bring nutrients into the cell and flush out waste.

The Purdue-led team was the first to achieve an image of the middle step of the process, capturing the molecular interactions as material passes through the membrane.

"By understanding the mechanisms of this process, researchers may be able to design more effective treatments for diseases that involve this group of proteins, such as cancer and cystic fibrosis," said Chen, who also is a member of Purdue's structural biology group within the College of Science. "With this knowledge, researchers may be able to inhibit or activate this mechanism, depending on what is needed to counteract the disease. For instance, many cancer cells are resistant to drug treatments because the cells pump the drugs out through these channels before they can work."

Amy Davidson, who collaborated on this work with Chen, said capturing an image of the intermediate stage is a giant step toward learning the complete process.

"If you look at only the before and after stages, you don't really know all that goes on," said Davidson, an associate professor of chemistry at Purdue. "The intermediate stage provides all of this information about how the process really works. It shows all of the main components of the system interacting, which had not been seen before. It is a snapshot of what happens halfway through the entry process and is a very clear picture of how things work."

The research team used X-ray c
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University  
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Purdue researchers click nutrition with camera diet study
2. Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Texas researchers and educators head for Antarctica
5. MGH researchers describe new way to identify, evolve novel enzymes
6. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
7. U of MN researchers discover noninvasive diagnostic tool for brain diseases
8. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
9. Researchers discover new strategies for antibiotic resistance
10. Researchers find new taste in fruit flies: carbonated water
11. Binghamton University researchers investigate evolving malaria resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purdue researchers obtain a snapshot clarifying how materials enter cells
(Date:9/18/2014)... Sept. 18, 2014 -- Arizona turned its newborn screening program ... few short months, earning it the first-ever Newborn Screening Quality ... of Dimes presented Will Humble, M.P.H., Arizona,s Department of Health ... today. Mr. Humble established a policy of full transparency for ... newborn blood samples to the lab for analysis, and set ...
(Date:9/18/2014)... carbon and nitrogen comprise all spheres of our ... have caused imbalances and perturbations that resulted in ... GHGs result in climate changes which influence the ... the atmosphere. Understanding these feedback mechanisms has become ... science during the past three decades. , In ...
(Date:9/18/2014)... up to 400 kilometres in search of a home, which ... Clownfish spend their entire adult lives under the protection of ... open ocean, says study co-author, Dr Hugo Harrison from the ... at James Cook University. , "In the past we haven,t ... rare glimpse into how far they can swim, crossing large ...
Breaking Biology News(10 mins):March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3Greenhouse gas research enters a new era 2Nemo's epic journey to find a new home 2
... species (ROS), or 'oxygen radicals', have been identified as ... prevalence linked to inflammation-associated syndromes and a variety of ... San Diego Branch of the Ludwig Institute for Cancer ... repair and cell cycle control genes in yeast that ...
... in winter and spring snow cover over Southwest Asia and ... blooms of ocean plants in the Arabian Sea. , The ... both temperature and pressure systems between the Indian subcontinent and ... mix the ocean water in the Western Arabian Sea. This ...
... benefit from treatment with mixtures of customized antibodies. In ... National Academy of Sciences (USA), a team of Weizmann ... form a web that destroys the cancer cell's communication ... intensive cancer research led to the identification of a ...
Cached Biology News:Yeast Network Prevents Damage By Oxygen Radicals 2NASA study finds snow melt causes large ocean plant blooms 2Two are better than one 2
(Date:9/19/2014)...  An entire month is dedicated to one of ... disease (CMT) – a debilitating neuromuscular disease affecting the ... weakness, and foot and hand deformities. CMT affects 1 ... is a progressive disease, and over time patients lose ... such as leg braces, wheelchairs and scooters to get ...
(Date:9/19/2014)... , September 19, 2014 ... latest developments, patents and results of studies and trials. ... Lilly and Company (NYSE: LLY ), Gilead ... (NASDAQ: CELG ) and Arena Pharmaceuticals Inc. ... leader in developing prodrug therapeutics for the treatment of ...
(Date:9/19/2014)... 2014 , The first grants ... Paediatric Endocrinology (ESPE) Meeting  Investment supports innovative ... in the field of growth  , EMD ... Germany , today announced the first recipients of ... awards were announced during a Satellite Symposium organized by ...
(Date:9/18/2014)... , Sept. 18, 2014 About ... testing, is performed outside a clinical laboratory. It ... in administrating appropriate treatments and medication. POCT is ... prevalence of lifestyle diseases such as diabetes, heart ... user-friendly. POCT devices are standardized to minimize errors ...
Breaking Biology Technology:September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2
... , , , Kurt Lucas, Eppendorf AG , ... , Significance of cell fusion , ... methods in modern biology, such as the production of monoclonal ... Compared to the , chemically induced cell fusion via polyethylene ...
... , , , , , , , ... procedure.(1,2,3), The basic protocol given here works with E. coli cultures grown ... LB or DYT, or in 250 , ml Terrific Broth. , ... Pellet bacteria from the culture at 10,000 x g for 5 minutes at room , ...
... , , , , , , ... Eppendorf 5 Prime, Inc. , , , , ... It is not convenient in all instances to have blood drawn for gDNA extraction. , ... gDNA from , saliva with only slight modifications to the ...
Cached Biology Technology:Principles and applications of electrical cell fusion 2Principles and applications of electrical cell fusion 3Principles and applications of electrical cell fusion 4Principles and applications of electrical cell fusion 5Basic Plasmid DNA Isolation Protocol 2Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 2Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 3Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 4Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 5Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 6
... The EC570-90 is a compact, lightweight, high ... 500 volts or 2500 milliamps. It is an ... RNA submarine gels. It is also ideal for ... time can be set to automatically end a ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
QCPN...
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
Biology Products: