Navigation Links
Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
Date:11/15/2007

WEST LAFAYETTE, Ind. - Pre-malignant mammary lesions in dogs and humans display many of the same characteristics, a discovery that could lead to better understanding of breast cancer progression and prevention for people and pets, said a Purdue University scientist from the School of Veterinary Medicine.

A group of scientists including Sulma Mohammed have found similarities between benign lesions that are considered to carry risk for developing breast cancer in both canines and humans. Breast cancer is the second leading cause of cancer deaths in women.

"Dogs develop these lesions spontaneously in contrast to other available models and are exposed to the same environmental risk factors as humans," said Mohammed, an associate professor in comparative pathobiology. "These shared features make the dog an ideal model to compare the breast lesions that will progress to cancer and those that will regress. Such a model will facilitate customized treatment and prevention strategies."

Due to the success of mammographic screening and awareness by women, abnormal cell growth within breast tissues is frequently diagnosed, Mohammed said. These intraepithelial lesions are recognized risk factors for invasive cancer, and their presence affects patient management decisions.

"Once a lesion is identified, it can be treated with hormonal therapy if it is estrogen receptor (ER)-positive, but for low-risk and ER-negative lesions, we can't do anything but wait and watch to see if it grows into a tumor," Mohammed said. "With a dog model, we could study these lesions and test different prevention modalities before it becomes a cancer."

The research appears in this month's issue of the Journal of Cancer Epidemiology, Biomarkers, and Prevention. Mohammed's co-authors include Sunil Badve from Indiana University; Margaret (Peg) Miller, Jun Xie and Elisabetta Antuofermo from Purdue; and Salvatore Pirino from the Sassari University School of
'/>"/>

Contact: Maggie Morris
maggiemorris@purdue.edu
765-494-2432
Purdue University  
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Purdue researchers click nutrition with camera diet study
2. Research shows skeleton to be endocrine organ
3. Newly created cancer stem cells could aid breast cancer research
4. Dominant cholesterol-metabolism ideas challenged by new research
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. Texas researchers and educators head for Antarctica
7. MGH researchers describe new way to identify, evolve novel enzymes
8. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
9. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
10. U of MN researchers discover noninvasive diagnostic tool for brain diseases
11. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
(Date:6/18/2015)... YORK , June 18, 2015 This ... US$ Million by the following Product Segments, which includes ... Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and Nephelometric ... the US, Canada , ... Asia-Pacific , Latin America ...
(Date:6/17/2015)... Calif. , June 17, 2015  Synaptics ... human interface solutions, today announced that Xiaomi, one ... the Synaptics ® ClearPad ® family ... display driver integrated circuits (DDICs) for its latest ... By leveraging ClearPad for full in-cell display solutions ...
(Date:6/16/2015)... , June 16, 2015 Fingerprint Cards ... fingerprint sensors in the company,s portfolio from one of its ... planned to mainly take place during the third quarter 2015. ... Asia . Jörgen Lantto, CEO of ...   the   growing interest from smartphone OEMs in integrating ...
Breaking Biology News(10 mins):Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... November 18, 2008 The American Journal of Preventive ... will be featured at the "Changing Climate Changing ... event is Guest Editor Howard Frumkin, MD, DrPH, speaking ... "Climate change is a key public health challenge. ...
... Internationally recognized climate scientist and economist Jae Edmonds ... carbon capture and sequestration in climate stabilization in the ... Greenhouse Gas Technologies. He is one of nearly a ... National Laboratory who will present new findings and insights ...
... Biologists at Washington University in St. Louis have made major ... potentially harmful genes. Differential gene expression ... For instance, although every cell in the human body ... get activated to make an eye different from a toe. ...
Cached Biology News:Issues at intersection of climate change and health impact global well-being 2Issues at intersection of climate change and health impact global well-being 3Issues at intersection of climate change and health impact global well-being 4PNNL leadership in carbon sequestration featured at international conference 2New gene-silencing pathway found in plants 2New gene-silencing pathway found in plants 3New gene-silencing pathway found in plants 4
(Date:7/3/2015)... ... July 03, 2015 , ... ... industry-leading products for use in applications such as animal waste reduction, bioremediation, ... plants and restaurant kitchen settings, announced today that it will be showcasing, ...
(Date:7/3/2015)... , July 3, 2015 ... voivat hakea verkossa osoitteessa  http://www.openinnovationinscience.at ... Open Innovation in Science" -jatkokoulutusohjelmaan ... Boltzmann Gesellschaftin (LBG) tekemän, kansainvälisiä ... mukaan terveystieteiden kaksi suurinta haastetta ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Alexander Group, ... professional service industries alike-- typically known for its consummate professionalism-- embarks each year ... cause and break from their day jobs. , "Our motto has always been ...
(Date:7/3/2015)... ... 03, 2015 , ... The global failure analysis market is expected to reach ... bioscience market is expected to grow at the highest CAGR of 8.46%; its growth ... the research labs and academic institutions for root cause analysis of failure. The market ...
Breaking Biology Technology:DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3The Alexander Group Declares Their Independence with a Bit of Levity 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5
... , IRVINE, Calif., Aug. 31 ... of Pulse CO-Oximetry(TM) and Measure-Through Motion and Low-Perfusion pulse oximetry, ... the Thomas Weisel Partners Healthcare Conference 2009 at the Four ... at 10:20 a.m. EDT. A live audiocast of the ...
... NOVATO, Calif., Aug. 31 Raptor Pharmaceuticals Corp. ("Raptor" ... will hold its 2009 Annual Meeting of Stockholders on Monday, September ... at 9 Commercial Blvd., Suite 200, Novato, California. All stockholders of ... at such annual meeting and all stockholders of Raptor are invited ...
... , , , ... ARAY ), a global leader in the field ... treatment planning capabilities of the CyberKnife(R) Robotic Radiosurgery System at ... (ESTRO) Conference on Physics and Radiation Technology for Clinical Radiotherapy ...
Cached Biology Technology:Masimo to Present at the Thomas Weisel Partners Healthcare Conference 2009 2Raptor Pharmaceuticals Schedules 2009 Annual Meeting of Stockholders 2Raptor Pharmaceuticals Schedules 2009 Annual Meeting of Stockholders 3Accuray to Showcase CyberKnife Treatment Planning Capabilities at Preeminent Radiation Oncology Conference 2Accuray to Showcase CyberKnife Treatment Planning Capabilities at Preeminent Radiation Oncology Conference 3Accuray to Showcase CyberKnife Treatment Planning Capabilities at Preeminent Radiation Oncology Conference 4