Navigation Links
Purdue biologists identify new strategy used by bacteria during infection
Date:7/12/2011

WEST LAFAYETTE, Ind. - Purdue University biologists identified a new way in which bacteria hijack healthy cells during infection, which could provide a target for new antibiotics.

Zhao-Qing Luo, the associate professor of biological sciences who led the study, said the team discovered a new enzyme used by the bacterium Legionella pneumophila - which causes Legionnaires' disease - to control its host cell in order to take up residence.

"Legionnaires' disease is a severe form of pneumonia, and this finding could lead to the design of a new therapy that saves lives," Luo said. "At the same time it also provides great insight into a general mechanism of both bacterial infection and cell signaling events in higher organisms including humans."

Successful infection by Legionella pneumophila requires the delivery of hundreds of proteins into the host cells that alter various functions to turn the naturally hostile environment into one tailor-made for bacterial replication. These proteins tap into existing communication processes within the cells in which an external signal, such as a hormone, triggers a cascade of slight modifications to proteins that eventually turns on a gene that changes the cell's behavior, he said.

"Pathogens are successful because they know how information in our cells is relayed and they amplify some signals and block others in order to evade the immune system and keep the cell from defending itself," Luo said. "Despite our understanding of this, we do not know much about how the proteins delivered by the bacteria accomplish this - how they work. This time we were able to pinpoint an enzyme and see how it disrupted and manipulated a specific signaling pathway in order to create a better environment for itself."

The signaling pathway involved was only recently identified, and the discovery by Luo and graduate student Yunhao Tan also provides a key insight into its process. A paper deta
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Purdue-led team studies Earths recovery from prehistoric global warming
2. Purdue startup hopes to change the way we test cancer drugs
3. Purdue team creates engineered organ model for breast cancer research
4. NASA, Purdue study offers recipe for global warming-free industrial materials
5. Protein can help cells or cause cancer, Purdue researcher finds
6. Purdue study finds dairy better for bones than calcium carbonate
7. Purdue study suggests warmer temperatures could lead to a boom in corn pests
8. Purdue researcher invents molecule that stops SARS
9. New curation tool a boon for genetic biologists
10. 2 UC Davis plant biologists named as HHMI-GBMF investigators
11. Announcing BIOLOGY OPEN from the Company of Biologists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Purdue biologists identify new strategy used by bacteria during infection
(Date:8/21/2014)... by an international standards process, will be available soon ... invited review published in the OnlineFirst version of ... official journal of the American Society for Parenteral and ... the occurrence of misconnection that can be harmful and ... used to join medical devices, components, and accessories to ...
(Date:8/21/2014)... replicated one of the crucial steps in photosynthesis, opening ... could manufacture hydrogen as a fuel. , "Water is ... prospect to use them to create hydrogen, and do ... the ARC Centre of Excellence for Translational Photosynthesis in ... potential as a zero-carbon replacement for petroleum products, and ...
(Date:8/21/2014)... the pancreas digesting itself resulting in severe abdominal pain, ... around 20,000 patients are diagnosed with the disease resulting ... treatment is restricted to intravenous fluid and nutritional support. ... Life Sciences, who led the research, said "The major ... stones and excessive alcohol intake combined with a high ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Water and sunlight the formula for sustainable fuel 2Insulin offers new hope for the treatment of acute pancreatitis 2
... in Spanish . , Those who enjoy ... teas may tend to overlook the benefits of drinking herbal ... Research magazine, the idea that herbal teas may provide a ... U.S. Department of Agriculture (USDA)-funded scientists in Boston, Mass., have ...
... March 1, 2011 When patients receive a bone marrow ... cells. Fresh stem cells are needed when a patient is ... blood cells, which can be caused by cancer or even ... that a bone marrow transplant might not succeed because the ...
... has the potential to revolutionise the way autopsies are ... pathologists and radiologists at the University of Leicester in ... The technique developed by a team in the ... Leicester, has been published today (1 March) in ...
Cached Biology News:Don't underestimate the power of herbal teas 2How long do stem cells live? 2New non-surgical autopsy technique set to revolutionize post-mortem practice 2
(Date:8/21/2014)... N.Y. , Aug. 21, 2014 ... launch of their Nutraceutical "TELO-20 for Dogs" with ... only Telomere-lengthening supplement in the world for dogs. ... of every chromosome in the body. A wealth ... leading experts in Telomere Science and Aging, including ...
(Date:8/21/2014)... Mathematic studies at the Program for Evolutionary ... by the Jeffrey Epstein VI Foundation , have shown ... identified for elimination. These aggressive cells are the driver mutations ... topological map of what to look for when examining tumors, ... tumor cells can be extracted from biopsy, it,s very difficult ...
(Date:8/21/2014)... , Aug. 21, 2014  Four-dimensional (4-D) ... behaviors based on external stimuli such as changes ... have a disruptive effect in multiple industries.  In ... business landscape by printing objects ranging from human ... automotive sectors. Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... MO (PRWEB) August 21, 2014 ... service biopharmaceutical contract development and manufacturing organization (CMO) ... Progenics Pharmaceuticals, Inc., an oncology company focused on ... treating cancer, to manufacture the anti-prostate specific membrane ... ADC product candidate. Under the agreement the ...
Breaking Biology Technology:Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3
... to Early Cardiovascular,Events in Asian Populations, WALTHAM, ... ILI ), announced today that Kenneth Kornman, Ph.D., ... findings on,the genetics of cardiovascular disease at the ... place from Oct. 31 -,Nov. 1, 2008, at ...
... Fingerprint portraits go global by incorporating cutting-edge localization technology online to target ... ... New York, NY (PRWEB) October 30, 2008 -- DNA 11, the original ... mark global growth with the launch of a new website that will ...
... databases enable ,researchers to quickly and effectively use these invaluable resources. ... ... announced the availability of newly updated tutorial suites on the DataBase of ... is a public resource for the analysis of promoter regions. , ...
Cached Biology Technology:Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 2Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 3Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 4DNA 11, Creators of DNA Art Goes Global 2Updated Online Tutorials for DBTSS, Pfam and PDB 2Updated Online Tutorials for DBTSS, Pfam and PDB 3
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... is a direct antibiotic-based selection system for ... colony survival, eliminating the need for costly ... provides close to 100% accuracy in recombinant ... for robot colony picking. This cloning kit ...
... software for the microscopy market by ... components and peripherals with powerful archiving, ... intuitive interface simplifies workflow and speeds ... powerful features such as image stitching, ...
Mouse monoclonal [IA-C6] to MHC Class II I Ab + Ad (FITC) ( Abpromise for all tested applications). Antigen: Tissue / cell preparation of Purified Mouse lymph node B cells...
Biology Products: