Navigation Links
Pulmonary fibrosis inhibited by pentraxin-2/SAP in research study
Date:2/10/2011

MALVERN, PA February 10, 2011 Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today the publication of collaborative research in the International Journal of Biochemistry and Cell Biology entitled, "TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P." The research showed that human Pentraxin-2 (PTX-2), also called human Serum amyloid P (SAP), potently inhibits all undesirable pro-fibrotic pathologies driven by TGFβ1 and represents a novel therapeutic approach for the treatment of diseases that involve lung fibrosis, including idiopathic pulmonary fibrosis (IPF). This research validates that PTX-2/SAP can have therapeutic effects even in conditions driven by TGFβ1 growth factor, and builds on the body of research showing the unique role of PTX-2/SAP in activating the body's natural ability to resolve tissue damage in disease processes that cause fibrosis and inflammation.

In this study, researchers examined the effects of PTX-2/SAP in the lung specific TGFβ1 transgenic mouse model, since many of the pathogenic mechanisms observed in lung fibrosis can be stimulated by the growth factor TGFβ1. Highlights of the results from this study validating the potential therapeutic effects of PTX-2/SAP in pulmonary fibrosis included:

  • PTX-2/SAP inhibited all of the pathologies driven by TGFβ1 including apoptosis, airway inflammation, pulmonary fibrocyte and M2 macrophage accumulation and collagen deposition, without affecting the levels of TGFβ1 in the lung;

  • An abbreviated therapeutic dose schedule was equally efficacious and demonstrated a sustained durability of effect following cessation of drug dosing, suggesting that intermittent dosing may be feasible in human patients;

  • PTX-2/SAP levels were reduced in the serum of IPF patients when compared to clos
    '/>"/>

Contact: Kathryn Morris
kathryn@theyatesnetwork.com
845-635-9828
Yates Public Relations
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. A possible role for Smurf1 in pulmonary arterial hypertension
2. Test could predict which idiopathic pulmonary fibrosis patients will become severely ill
3. New potential to treat chronic obstructive pulmonary disease
4. Endothelin drugs benefit those with pulmonary hypertension
5. Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
6. Pulmonary hypertension in children may result from reduced activity of gene regulator
7. Gene with probable role in human susceptibility to pulmonary tuberculosis identified
8. Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
9. 1 step closer to a drug treatment for cystic fibrosis, MU professor says
10. Pitt researchers discover big role for microRNA in lethal lung fibrosis
11. Drug may treat cystic fibrosis, other diseases caused by nonsense mutations, UAB researcher says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... 18, 2013 The herbal extract of a yellow-flowered ... to increase the lifespan of fruit fly populations by ... researchers. , But it,s how Rhodiola ... that grabbed the attention of study leaders Mahtab Jafari ... works in a manner completely unrelated to dietary restriction ...
(Date:6/18/2013)... June 2013). A team of internationally recognized feline experts ... Ellis from the University of Lincoln, U.K. and Dr ... were invited by the International Society of Feline Medicine ... to compile guidelines for veterinarians, owners and those working ... of the domestic cat. The new guidelines appear in ...
(Date:6/17/2013)... locations with central nervous system infections may well be ... according to a study to be published in ... Society for Microbiology. Researchers have detected the virus in ... central nervous system infections of unknown cause, and in ... pigs and poultry, suggesting animals may serve as reservoirs ...
Breaking Biology News(10 mins):Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2Feline behavior experts release guidelines to improve the welfare of cats 2New virus discovered in patients with central nervous system infections 2New virus discovered in patients with central nervous system infections 3
... RIDGE, Tenn, April 8, 2011 -- A newly sequenced ... of Energy,s Oak Ridge National Laboratory could contain clues ... of mercury. Methylmercury, a potent human neurotoxin, ... transform inorganic mercury into its more toxic cousin. Few ...
... Neurosurgeons from NYU Langone Medical Center will present techniques ... the annual meeting of the American Association of Neurological ... Convention Center in Denver. The Department of ... as one of the top ten hospitals in the ...
... ST. LOUIS Saint Louis University researchers have identified ... fluid from tissues to lymphatic vessels. It may be possible ... organ to another organ and improve the effectiveness of vaccines. ... consisting of vessels in the body. It defends the body ...
Cached Biology News:Bacterial genome may hold answers to mercury mystery 2NYU Langone experts present advances at American Association of Neurological Surgeons Meeting 2Outsmarting cancer cells: SLU scientists learn how they spread 2
(Date:6/18/2013)... Israel , June 18, 2013 ... Active Pharmaceutical Ingredients (APIs), generic and innovative intermediates, and finished ... that the company has been granted a United ... the US and Europe for the ... number 8,410,176 B2 is titled Intermediate Compounds and Processes ...
(Date:6/18/2013)... Canada (PRWEB) June 18, 2013 ... oversight of pharmaceutical advertising and promotion, and review ... Viewers will learn how to apply these principles ... examples:, ,     The fundamentals on FDA ... and promotional labeling ,     Assessing traditional and ...
(Date:6/18/2013)... 2013 Research and ... addition of the "Injectable Drug Delivery ... Devices [Disposables & Reusable, Fillable & Prefilled, ... Therapeutics [Diabetes & Oncology] - Global Forecasts ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ...
(Date:6/18/2013)... As a leading provider of telehealth ... release of their infographic - " 8 New ... goal was to leverage an information graphic to ... 3.0 and mHealth.The infographic features a list of ... the fitness industry in unimaginable ways; turning science ...
Breaking Biology Technology:Mapi Pharma Granted United States Patent for Pain Relief Medication "Tapentadol" 2Drug Advertising and Promotion Labeling: FDA Regulations, New Webinar Hosted by Xtalks 2Injectable Drug Delivery Market by Formulations, Devices & Therapeutics - Global Forecasts to 2017 2Injectable Drug Delivery Market by Formulations, Devices & Therapeutics - Global Forecasts to 2017 3MeMD, Inc Releases Infographic Featuring the Top Eight Technologies that are Revolutionizing Health and Fitness Today 2
... Jan. 23 PPD, Inc. (Nasdaq:,PPDI) today announced ... services,into China through an exclusive agreement with Peking ... PPD to begin,immediately providing biopharmaceutical clients with its ... China., "Chinese law makes it extremely difficult ...
... 23 /PRNewswire/ - Dalton Medicinal Chemistry Partners,the ... announces that it,has achieved another targeted milestone ... (Canada) Ltd., Dalton Medicinal Chemistry Partners ... and synthesize novel compounds against an,antiviral target ...
... modeled after biological olfaction, the challenge has been to ... combinatorial complexity to detect odors in the real world. ... manufactured with exact chemical precision and reproducibility. , In ... journal PLoS Biology, Joel White, Mary AtKisson, John Kauer ...
Cached Biology Technology:PPD Expands Global Central Lab Services into China 2PPD Expands Global Central Lab Services into China 3
Rad51, N-terminal...
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Goat polyclonal to T7 tag (Agarose) Immunogen: Goats were immunized with MASMTGGQQMG (T7) conjugated to KLH.After multiple immunizations in Freund's adjuvant, serum was collected....
Rabbit polyclonal to Olfactory Receptor LS189744 ( Abpromise for all tested applications)....
Biology Products: