Navigation Links
Proteomic analysis of immunocamouflaged surfaces
Date:5/25/2012

gs for relative and absolute quantitation (iTRAQ) labeling followed by mass spectrometry (MS). The reduction in plasma adsorption occurred because of polymer-mediated thermodynamic steric exclusion and surface charge camouflage. The iTRAQ-MS findings also demonstrated that the grafted polymer prevented surface interactions with plasma proteins involved in the immune recognition of biomaterials and allogeneic cells.

Biologically, the reduced surface-plasma interactions would enhance biocompatibility by camouflaging antigenic sites and preventing the generation of immune recognition signals. The findings of this paper are supportive and predictive of previously reported observations of the immunocamouflage of RBCs and lymphocytes and of the prevention of viral invasion of cells. The knowledge derived from these proteomic studies will help to further define the physical and chemical parameters necessary for efficient immunocamouflage of allogeneic cells, tissues and biomaterials. The practical application of the immunocamouflage technology could have a significant impact on improving the safety of donor cells (e.g., RBCs), tissues and implantable biomaterials in clinical medicine.

Qualitative and quantitative analysis of plasma surface interactions demonstrated the efficacy of immunocamouflage in preventing plasma protein adsorption. Moreover, iTRAQ analysis provided clear evidence for reduced adsorption of proteins associated with the immunological recognition of foreign cells/tissues and biomaterials.


'/>"/>
Contact: Mark D. SCOTT
mdscott@mail.ubc.ca
Science in China Press
Source:Eurekalert  

2

GOOD

Page: 1 2

Related biology news :

1. AMP opposes exclusive licensing of NIH proteomics patent
2. TGens Center for Proteomics selected as Waters Center of Innovation
3. Case Western Reserve and NeoProteomics announce exclusive option
4. Reportlinker Adds Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
5. GEN reports on rediscovered technology to bolster proteomics research
6. Protein extremes gain relevance in massive proteomic studies
7. KINAXO Biotechnologies and Bayer Vital GmbH Collaborate in Phosphoproteomics Biomarker Identification
8. Reportlinker Adds Proteomics: Technologies and Global Markets Report
9. Proteomics: Finding the key ingredients of disease
10. New manual presents robust, state-of-the-art proteomics methods for teaching and research
11. Proteomics study yields clues as to how tuberculosis might be thwarting the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Proteomic analysis of immunocamouflaged surfaces
(Date:6/19/2013)... provider of scientific, technical and medical information products and ... new open access journal, GeoResJ . , ... and planetary science journals portfolio has its first open ... forum for rapid publication of top research within the ... by six Executive Editors, each covering a different discipline, ...
(Date:6/18/2013)... UT Arlington environmental engineer has been awarded a ... to ensure water quality and flow in the ... , Andrew Kruzic, UT Arlington associate professor of ... locations to add monochloramine to the water in ... new pump stations and pipelines. Adding monochloramine is ...
(Date:6/18/2013)... $12.7 million to match nine academic research groups ... explore new treatments for patients in eight disease ... schizophrenia. The collaborative pilot initiative, called Discovering New ... the National Center for Advancing Translational Sciences (NCATS) ... The process of developing a new therapeutic is ...
Breaking Biology News(10 mins):UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2NIH to fund collaborations with industry to identify new uses for existing compounds 2NIH to fund collaborations with industry to identify new uses for existing compounds 3NIH to fund collaborations with industry to identify new uses for existing compounds 4
... A Century of Change, literally took 100 years to write. ... from 1906-1909. It was repeated from 1956-1958 and a technical ... anniversary of that first survey was approaching, ornithologists Mike Ward, ... of opportunity to do it again and write a book, ...
... the United States and Japan analyzed fossil evidence found ... horned dinosaur. The newly identified genus, Koreaceratops ... the late Early Cretaceous period. The specimen is ... The partial skeleton includes a significant portion of the ...
... social stress activates the immune system and accelerates the ... pressure, however, may stop this process. This is the ... Gothenburg, Sweden. Several large studies have clearly shown ... the risk of developing cardiovascular disease. However, little is ...
Cached Biology News:New book on 100 years of Illinois birds 2New book on 100 years of Illinois birds 3New book on 100 years of Illinois birds 4Scientists announce discovery of first horned dinosaur from South Korea 2Social stress leads to atherosclerosis 2
(Date:6/19/2013)... , June 19, 2013 Biotechnology industry pioneer ... up with financial software provider BlackLine Systems  and ... SAP ) for a webinar next week entitled ... Solutions from BlackLine and SAP to Help Keep Its Account ... http://photos.prnewswire.com/prnh/20061117/LAF027LOGO ) The webinar, geared at ...
(Date:6/19/2013)... A new look at “big glass” and ... will highlight technical sessions at SPIE Photomask Technology ... 33rd year, the three-day event is the industry’s largest ... approximately 100 technical presentations and numerous networking lunches and ... optics and photonics , the meeting will be held ...
(Date:6/18/2013)... HONG KONG, June 18, 2013 China Cord ... the "Company"), China,s leading provider of cord blood collection, ... storage services, today announced its preliminary unaudited financial results ... year 2013 ended March 31, 2013. ... for the fourth quarter of fiscal 2013 increased by ...
(Date:6/18/2013)... 18, 2013 The human skin is the ... an important human body part. Similar to the liver, or ... to function, repair and grow. Recent reports from the mankatofreepress.com ... is just as important as other life supporting organs. The ... in skin cell reproduction, increase the appearance of skin, and ...
Breaking Biology Technology:Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 2Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 3Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 4‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 2China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 4China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 5China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 6China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 7China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 8China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 9China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 10China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 11China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 12China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 13Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin 2
... Jan. 4, 2011 Advanced Life Sciences Holdings, ... a biopharmaceutical company engaged in the discovery, development and ... infection, oncology and respiratory diseases, today announced that it ... Conference held January 10-12th in San Francisco. ...
... a biological weapon so specific, it can target an individual ... seeds of death are sown into the very blueprints of ... of us, buried deep within the human genetic code. How ... diseases? Doug Flanders ponders these very questions in ...
... Jan. 4, 2011 Reportlinker.com announces ... is available in its catalogue: ... Market: DNA Probes and Biochips New ... Strategies for Instrument and Reagent Suppliers ...
Cached Biology Technology:Advanced Life Sciences to Present at the Biotech Showcase™ 2011 Conference 2James Bond Meets Cheaper by the Dozen: An Action Thriller the Entire Family Will Enjoy 2Reportlinker Adds The 2011 Molecular Diagnostics Market: DNA Probes and Biochips New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 2
...
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Biology Products: