Navigation Links
Proteins to yield new clues in fight against osteoporosis
Date:9/29/2010

Troy, N.Y. A $1.76 million study at Rensselaer Polytechnic Institute seeks to identify new methods of diagnosing osteoporosis and inform the development of next-generation drugs to treat the bone disease.

The five-year study, funded by the U.S. National Institutes of Health (NIH), is led by Deepak Vashishth, professor and head of the Department of Biomedical Engineering at Rensselaer. Partnering with researchers from Yale University and the Hospital of Special Surgery, Vashishth's will investigate what role two proteins, osteocalcin and osteopontin, play in bone fractures over time.

"Age-related bone fractures are a major health problem in the United States, and the risk of suffering this kind of fracture increases as we get older and our bones grow more fragile," Vashishth said. "Our study examines how the proteins osteocalcin and osteopontin may impact bone fragility and fracture. We're confident that our results will lead to new methods of diagnosing osteoporosis, provide new targets for drug development, and advance the fight against this devastating disease."

The new study builds from Vashishth's past research into the effects of modifying the molecular composition of certain proteins in bone, better understanding the relationship of bone biology and bone fracture, and developing new treatments to combat and reverse bone fragility. While bone mass historically was considered to be a significant predictor of bone fracture risk, current studies show bone loss to be a key contributor, but not the sole cause, of bone fracture. This means other factors, such as the molecular biology of an individual's bones, need to be examined in order to more fully understand age-related bone fragility.

Bones are comprised primarily of bone matrix, made up of woven or stacked cells. The proteins located between these cells, called extracellular matrix proteins, may offer some clues to unlocking the secret of bone fragility. Evidence suggests two such proteins, osteocalcin and osteopontin, can influence the formation of nanoscale damage and microcracks in bone. However, very little is known about how or why this works.

"We will investigate the effects of osteocalcin and osteopontin on damage morphology and bone fragility at the nanoscale, microscale, and macrostructural scale," Vashishth said. "We believe our results will show, conclusively, how the combination of nanoscale damage, paired with creation of nanoscale bands affected by the proteins, actually impact the overall structure and fragility of the bone. Once this is established, we and other researchers will be able to start working on new treatments for osteoporosis and related bone diseases."


'/>"/>

Contact: Michael Mullaney
mullam@rpi.edu
518-276-6161
Rensselaer Polytechnic Institute
Source:Eurekalert

Related biology news :

1. Saliva proteins could help detection of oral cancer
2. New lab manual focuses on essential methods for purifying and characterizing proteins
3. Proteins in sperm unlock understanding of male infertility says new study
4. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
5. Luminescence shines new light on proteins
6. Proteins strangle cell during division
7. Just a little squeeze lets proteins assess DNA
8. New technique is quantum leap forward in understanding proteins
9. Motor nerve targeting to limb muscles is controlled by ephrin proteins
10. JDRF-funded researchers discover proteins regulating human beta cell replication
11. Fluorescent proteins illuminating biomedical research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/17/2017)... April 17, 2017 NXT-ID, Inc. (NASDAQ: ... the filing of its 2016 Annual Report on Form 10-K on ... ... is available in the Investor Relations section of the Company,s website ... SEC,s website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... ... automates the most dangerous step of sample prep for metals digestion—the addition of ... automation at an affordable price. The system is ideal for any laboratory performing ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... The new ... and time. The pocket testers even stand upright with a new cap design that ... or out in the field who need to test water quality. , The Oakton ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... a partnership with Cytena GmbH to launch the CloneSelect™ Single-Cell Printer™ in North ... to isolate single cells and provide visual documentation of monoclonality for use in ...
(Date:9/18/2017)... ... September 18, 2017 , ... Scholarly publisher ... the SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August to a new ... user experience and incorporate a number of enhancements and new features, the website ...
Breaking Biology Technology: