Navigation Links
Proteins to yield new clues in fight against osteoporosis
Date:9/29/2010

Troy, N.Y. A $1.76 million study at Rensselaer Polytechnic Institute seeks to identify new methods of diagnosing osteoporosis and inform the development of next-generation drugs to treat the bone disease.

The five-year study, funded by the U.S. National Institutes of Health (NIH), is led by Deepak Vashishth, professor and head of the Department of Biomedical Engineering at Rensselaer. Partnering with researchers from Yale University and the Hospital of Special Surgery, Vashishth's will investigate what role two proteins, osteocalcin and osteopontin, play in bone fractures over time.

"Age-related bone fractures are a major health problem in the United States, and the risk of suffering this kind of fracture increases as we get older and our bones grow more fragile," Vashishth said. "Our study examines how the proteins osteocalcin and osteopontin may impact bone fragility and fracture. We're confident that our results will lead to new methods of diagnosing osteoporosis, provide new targets for drug development, and advance the fight against this devastating disease."

The new study builds from Vashishth's past research into the effects of modifying the molecular composition of certain proteins in bone, better understanding the relationship of bone biology and bone fracture, and developing new treatments to combat and reverse bone fragility. While bone mass historically was considered to be a significant predictor of bone fracture risk, current studies show bone loss to be a key contributor, but not the sole cause, of bone fracture. This means other factors, such as the molecular biology of an individual's bones, need to be examined in order to more fully understand age-related bone fragility.

Bones are comprised primarily of bone matrix, made up of woven or stacked cells. The proteins located between these cells, called extracellular matrix proteins, may offer some clues to unlocking the secret of bone fragility. Evidence sugg
'/>"/>

Contact: Michael Mullaney
mullam@rpi.edu
518-276-6161
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Saliva proteins could help detection of oral cancer
2. New lab manual focuses on essential methods for purifying and characterizing proteins
3. Proteins in sperm unlock understanding of male infertility says new study
4. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
5. Luminescence shines new light on proteins
6. Proteins strangle cell during division
7. Just a little squeeze lets proteins assess DNA
8. New technique is quantum leap forward in understanding proteins
9. Motor nerve targeting to limb muscles is controlled by ephrin proteins
10. JDRF-funded researchers discover proteins regulating human beta cell replication
11. Fluorescent proteins illuminating biomedical research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... the "Access Control Market by Product, Application & ... report to their offering. , This ... to reach $10.4 billion by 2020, with an estimated ... report covers the products types such as contact cards ...
(Date:3/10/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce ... been named the "Number One Best Tech Gift ... Modern ( http://www.rethinkmodern.com/ ) is a web magazine focused ... that have a unique function or design.  ...
(Date:3/2/2015)... Ala. , March 2, 2015  Businesses ... processing. Data protection company Tharon Rankins Enterprises has ... that provides an ultra-safe way for businesses to ... their financial transactions. Beconux is ... Tharon Rankins Enterprises. Functioning similarly to an ATM ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Personal Data Protection Company Launches New Product 2
... University of the Negev researchers have developed techniques to ... adapt to hostile growing environments. In a recent ... Cell , BGU researchers were able show that by ... growth. Lateral root (LR) development is a highly regulated ...
... a paper published today in PNAS, scientists from the ... new insights into the workings of enzymes from a ... bacterium that causes tuberculosis. The new findings present possible ... pathogen but leave other microorganisms, which are beneficial to ...
... OAK RIDGE, Tenn., Feb. 14, 2011 -- Bioethanol ... become less costly because of plant engineering by The ... Ridge National Laboratory. In a paper published in ... , researchers describe their transgenic version of switchgrass as ...
Cached Biology News:2 in 1: Multi-tasking protein provides new approaches for anti-tuberculosis drugs 2New lignin 'lite' switchgrass boosts biofuel yield by more than one-third 2
(Date:3/26/2015)... The Market Element LLC, a leading inbound ... Designing Gig LLC to provide website design, development, and ... this alliance with Designing Gig represents a pivotal moment ... comprehensive, end-to-end, digital solution for our clients, which now ... Miller, president of The Market Element. “For small and ...
(Date:3/26/2015)... March 26, 2015 PAREXEL International ... clinical research organization , announced today ... agreement to acquire all of the business ... leading provider of specialized pharmacovigilance services, based ... collection, detection, assessment, monitoring, and prevention of ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 WriteResult, a ... with researchers from Yale University’s School of Public Health ... study participants during a 4 month-long project. The goal ... providing low income families with free access to fresh ... and diet-related health concerns like high blood pressure, diabetes ...
(Date:3/25/2015)... ROCKVILLE, Md. , March 25, 2015 ... for the Vaccine Industry Excellence (ViE) Award "Best Clinical ... second consecutive year that Optimal has been selected as ... World Vaccine Congress, receiving a "Highly Recommended" distinction in ... generate recognition of the efforts, accomplishments, and positive contributions ...
Breaking Biology Technology:The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2
... , , , , , , For 124 high-purity plasmid minipreps , ... Spin columns, , , ... , , Purification module: , ... Throughput: , 124 samples, , ...
... , , , , For purification of PCR products in low elution , volumes , ... Application: , PCR product cleanup, , ... Spin columns, , , Throughput: , ... DNA size range: , 70 bp 4 kb*, ...
... , , , , , ... System for cost-effective, fully automated, high-throughput DNA purification , ... chemistry eliminates the need , for a lysate ... a single plate and a simple bindwashelute procedure. The protocol , ...
Cached Biology Technology:DirectPrep 96 Miniprep System for cost-effective, high-throughput plasmid , DNA purification 2DirectPrep 96 Miniprep System for cost-effective, high-throughput plasmid , DNA purification 3DirectPrep 96 Miniprep System for cost-effective, high-throughput plasmid , DNA purification 4