Navigation Links
Proteins that stop a major signaling pathway can also generate new proteins
Date:4/24/2008

DURHAM, N.C. Duke University Medical Center researchers have recently discovered that a crucial communications pathway in cells not only stops cells from making proteins, it also makes them go. The team was able to define the way in which proteins called beta arrestins (for their role in stopping signals) also turn on pathways that ultimately lead to the production of new proteins in virtually all tissues in the body.

Because proteins are the building blocks for all cells, this new pathway for the general control of protein manufacturing has opened a new universe for biological studies.

The beta arrestins were discovered two decades ago as the off switches for G protein-coupled receptors (GPCRs) on the cell surface, which do the job of sending and receiving important signals for cells. This mechanism is the target of about a third of all pharmaceuticals today.

The GPCRs, which were first theorized and discovered at Duke by the study's senior author, Robert J. Lefokowitz, MD, begin a signaling cascade that transmits a message from the cell surface, such as a hormone or neurotransmitter, to the cell's interior and tells it to do something, such as cranking out a particular protein.

These receptors regulate virtually all physiological processes, everything from heart rate to mood. Research on GPCRs has led to numerous successful drugs, including beta blockers which help relieve hypertension, angina and coronary disease, as well as new antihistamines and ulcer drugs. They also formed the basis of Nobel Prize winning work on smell receptors.

"The reason the new work is so exciting to me is that it reminds us, yet again, how the scientific process continuously renews itself, said Lefkowitz, James B. Duke Professor of Medicine and investigator of the Howard Hughes Medical Institute. "We discovered the beta arrestins almost 20 years ago, and now we find out they play signaling roles we never dreamed of back then. We are hopeful that these new ideas may lead to new types of drugs."

The study's findings, published in this month's Journal of Biological Chemistry, identified an enzyme called Mnk1 which is activated by beta-arrestin signaling. "What's been discovered here is that beta arrestins initiate important cell signals in their own right, and specifically the control over protein synthesis indicates that they may possess wide control of biological functions," said Scott DeWire PhD, lead author and adjunct assistant professor of medicine at Duke University.

"This added layer of complexity provides us opportunities to study receptors in a whole new way, and possibly identify beta-arrestin-specific signaling," DeWire said. "This is something completely unexpected according to the traditional dogma. Ten years ago, nobody would have imagined that beta-arrestins, with their ability to stop the GPCR signals, could exert global control over protein synthesis."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. Pathogen virulence proteins suppress plant immunity
2. Statistics are insufficient for study of proteins signal system
3. Scientists rebuild ancient proteins to reveal primordial Earths temperature
4. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
5. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
6. Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
7. Cystic fibrosis proteins photographed interacting
8. MIT IDs proteins key to brain function
9. Proteins pack tighter in crowded native state
10. Legionnaires bacterial proteins work together to survive
11. New approach builds better proteins inside a computer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
Breaking Biology Technology: