Navigation Links
Protein's new role discovered in autoimmune disease
Date:1/2/2008

BIRMINGHAM, Ala. - Investigators at the University of Alabama at Birmingham (UAB) have identified the previously unknown role of a chemical 'messenger' leading to autoimmune disorders like rheumatoid arthritis and lupus.

The messenger is the naturally occurring chemical interleukin 17 (IL-17), an immunity protein.

UAB researchers pinpointed an unknown role IL-17 plays in autoimmune and inflammatory responses, aside from its commonly known effects within immunity. Future research will home in on IL-17's unwanted actions and preserve its benefits within the immune system.

The new findings are published in the journal Nature Immunology.

In the study, UAB scientists blocked messenger signals from the IL-17 protein to the immune system of mice. This disruption significantly reduced the number of white blood cells, namely disease-causing B cells, clustered in the mice's spleen.

The number of B-cell clusters dropped from 17 percent to 2 percent when the IL-17 protein signals were blocked, the study authors said.

The drop was a clear sign that IL-17 plays a major role on shaping B cells' ability to create more and more disease-causing antibodies.

"The effect of IL-17 to slow down B cells, thereby enhancing their interaction with other immune regulatory cells a new and exciting discovery," said John D. Mountz, M.D., Ph.D., UAB professor of medicine and senior author on the study.

"This is surprising since previously IL-17 was thought to increase, but not decrease, cell motion. Now the effects of IL-17 on B cells can be explored more fully," Mountz said.

Many types of B cells make up the human immune system, which is regulated to sense and fight infection without attacking normal, healthy tissue. In autoimmune diseases that regulatory process becomes imbalanced.

"Knowing more about IL-17's ability to regulate unwanted B-cell migration will generate new ideas in the ongoing search for better drug targets in preventing and treating autoimmune disease," said Hui-Chen Hsu, Ph.D. an assistant professor in the UAB Division of Clinical Immunology and Rheumatology and lead author on the study.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
3. Depression, aging, and proteins made by a virus may all play role in heart disease
4. New approach builds better proteins inside a computer
5. Legionnaires bacterial proteins work together to survive
6. Proteins pack tighter in crowded native state
7. MIT IDs proteins key to brain function
8. Cystic fibrosis proteins photographed interacting
9. Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
10. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
11. New, more direct pathways from outside the cell-to-cell nuclei discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... UAS LifeSciences, one of the leading manufacturers ... Probiotics, into Target stores nationwide. The company, which has been manufacturing high quality ... list of well-respected retailers. This list includes such fine stores as Whole Foods, ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology: