Navigation Links
Proteins in sperm unlock understanding of male infertility says new study
Date:10/8/2008

Proteins found in sperm are central to understanding male infertility and could be used to determine new diagnostic methods and fertility treatments according to a paper published by the journal Molecular and Cellular Proteomics (MCP). The article demonstrates how proteomics, a relatively new field focusing on the function of proteins in a cell, can be successfully applied to infertility, helping identify which proteins in sperm cells are dysfunctional.

"Up to 50 percent of male-factor infertility cases in the clinic have no known cause, and therefore no direct treatment. In-depth study of the molecular basis of infertility has great potential to inform the development of sensitive diagnostic tools and effective therapies," write co-authors Diana Chu, assistant professor of biology at San Francisco State University and Tammy Wu, post-doctoral fellow at SF State. The study is included in a special Oct. 10 issue of MCP dedicated to the clinical application of proteomics.

"We suggest how the study of proteins is useful in the clinic, to help people move from infertile to fertile and ultimately to help couples have a baby," Chu said. "The ultimate goal is that a doctor could be able to say to a patient, 'this is the protein that is misregulated in your sperm and this is the drug that corrects it or decreases the level of that protein.' Understanding sperm proteins also means that a doctor could be able to inform patients of the likely success rates of different fertility therapies, an important factor given the high cost of fertility treatments."

More than 2 million couples in the U.S. are facing infertility. While many scientific studies examine the supply of sperm, its mobility and its ability to fertilize, Chu argues that a wider array of sensitive tests including studies of cell proteins are needed to determine the root causes of male infertility.

Proteins found in sperm cells are unique. This means therapies can be
'/>"/>

Contact: Diana Chu
chud@sfsu.edu
415-405-3487
San Francisco State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New lab manual focuses on essential methods for purifying and characterizing proteins
2. Saliva proteins could help detection of oral cancer
3. St. Jude study gives new insights into how cells accessorize their proteins
4. NIH awards Argonne $800,000 to develop tool to measure distances within proteins
5. Iowa State University researcher shows proteins have controlled motions
6. Candy-coating keeps proteins sweet
7. Improved technique determines structure in membrane proteins
8. Water is designer fluid that helps proteins change shape, scientists say
9. Novel structure proteins could play a role in apoptosis
10. Scientists reveal the key mechanisms for affinity between transient binding proteins
11. Plant biologists discover unexpected proteins affecting small RNAs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... By tracing nearly 3,000 genes to the earliest ... Florida scientists have created an extensive "Tree of ... next-generation DNA sequencing. , Among the study,s ... to small moths than to large ones, which ... The study also found that some insects once ...
(Date:7/31/2014)... the roughly 156,000 gas stations across the United ... of underground gas storage tankscorrosion that could result ... source of drinking water. In recent years, field ... corroding gas storage tank components such as sump ... of gasoline-ethanol blends and the presence of bacteria, ...
(Date:7/31/2014)... people make a rational choice to be liberal or ... it a matter of genetics?, Two political scientists from ... University say that neither conscious decision-making nor parental upbringing ... lean right. , A growing body of evidence shows ... core of political differences, the researchers say in the ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3NIST corrosion lab tests suggest need for underground gas tank retrofits 2Scientists find growing consensus: Political attitudes derive from body and mind 2
... reefs in the Indo-Pacific region, including the Great Barrier ... counterparts, leading marine scientists said today. Dr George ... of Excellence for Coral Reef Studies and The University ... in Cairns that coral reefs in the Indo-Pacific Ocean ...
... centuries, people made wine by stomping grapes with their bare feet. ... University of British Columbia,s Wine Research Centre. , Have you ever ... wine? Has one glass of Merlot or Shiraz resulted in a ... percent of people who are allergic to compounds that are in ...
... group at the Smithsonian Tropical Research Institute in Panama ... Florida Museum of Natural History discovered a new species ... in what is now northwestern South America. The team,s ... new turtle species is named Puentemys mushaisaensis because it ...
Cached Biology News:Our coral reefs: In trouble - but tougher than we thought 2Winemaking goes high-tech at the University of British Columbia 2
(Date:7/31/2014)... 2014 Today BioSpace , the leading life sciences employment ... spotlighting the life sciences community in Illinois , ... , Michigan , Minnesota , ... Ohio and Wisconsin . BioMidwest ... all job postings on BioSpace originating in this region in 2013. The ...
(Date:7/31/2014)... to see through organs and even the entire body ... fine-grained cellular structures has been a long-time dream of ... July 31st in the journal Cell has ... for making opaque organs, bodies, and human tissue biopsies ... The protocols could pave the way for a better ...
(Date:7/31/2014)... New York , July 31, 2014 ... by Transparency Market Research "Quantum Dots Market - Global ... - 2023," the market was valued at USD 88.5 ... 8,246.8 million by 2023, growing at a CAGR of ... full Quantum Dots Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html ...
(Date:7/31/2014)... 2014 According to a new ... Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ... Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry ... 2019," the global electrodes market for medical devices was ... estimated to reach a market worth USD 1,451.2 million ...
Breaking Biology Technology:Midwest Biotech Leaders Featured On BioSpace Map 2See-through organs and bodies will accelerate biomedical discoveries 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6
... 17 /PRNewswire/ - Norgen Biotek, an innovative Canadian ... for nucleic acids and protein purification, today announced ... A/S (NASDAQ OMX Copenhagen: "EXQ") to supply RNA ... Exiqon A/S is a Denmark-based company active in ...
... The pro bono healthcare injury prevention website ... that its newly instituted Safe Lifting Leadership Award ... of La Crosse, Wisconsin. The award was given ... safe patient handling, safe lifting, and caregiver injury ...
... Scheduled for Thursday, March 19, 2009 at 11:00 AM ... Milestone Scientific Inc. (OTC Bulletin Board: MLSS), ... that it intends to file its 2008 year-end results ... the U.S. Securities & Exchange Commission on Tuesday, March ...
Cached Biology Technology:Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S 2Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S 3Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S 4Gundersen Lutheran Health System is Recognized for Safe Lifting Leadership 2Gundersen Lutheran Health System is Recognized for Safe Lifting Leadership 3Milestone Scientific to Report 2008 Year-End Results on Tuesday, March 17, 2009 2Milestone Scientific to Report 2008 Year-End Results on Tuesday, March 17, 2009 3
...
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
... Bio-Beads SM-2 adsorbents are macroporous polystyrene beads ... high surface area for adsorbing organics of ... solutions. The beads are useful for the ... agents; for example, the removal of detergents ...
... Anti-Mi-2 Immunogen : Fusion ... residues 474-970 of human Mi-2 ... 0.105M NaCl, 0.035% sodium azide, ... routinely evaluated by immunoblot on ...
Biology Products: