Navigation Links
Proteins in sperm unlock understanding of male infertility says new study
Date:10/8/2008

Proteins found in sperm are central to understanding male infertility and could be used to determine new diagnostic methods and fertility treatments according to a paper published by the journal Molecular and Cellular Proteomics (MCP). The article demonstrates how proteomics, a relatively new field focusing on the function of proteins in a cell, can be successfully applied to infertility, helping identify which proteins in sperm cells are dysfunctional.

"Up to 50 percent of male-factor infertility cases in the clinic have no known cause, and therefore no direct treatment. In-depth study of the molecular basis of infertility has great potential to inform the development of sensitive diagnostic tools and effective therapies," write co-authors Diana Chu, assistant professor of biology at San Francisco State University and Tammy Wu, post-doctoral fellow at SF State. The study is included in a special Oct. 10 issue of MCP dedicated to the clinical application of proteomics.

"We suggest how the study of proteins is useful in the clinic, to help people move from infertile to fertile and ultimately to help couples have a baby," Chu said. "The ultimate goal is that a doctor could be able to say to a patient, 'this is the protein that is misregulated in your sperm and this is the drug that corrects it or decreases the level of that protein.' Understanding sperm proteins also means that a doctor could be able to inform patients of the likely success rates of different fertility therapies, an important factor given the high cost of fertility treatments."

More than 2 million couples in the U.S. are facing infertility. While many scientific studies examine the supply of sperm, its mobility and its ability to fertilize, Chu argues that a wider array of sensitive tests including studies of cell proteins are needed to determine the root causes of male infertility.

Proteins found in sperm cells are unique. This means therapies can be developed that target only these proteins and do not produce side effects in the patient or defects in the resulting offspring.

Chu's paper highlights a selection of recent advances in the study of proteins in sperm cells, citing studies that have identified specific proteins that correlate with infertility.

Chu argues that further large-scale clinical studies are needed to identify patterns in the proteins found in the sperm of infertile patients. This would help scientists to better understand which proteins to focus on, since each sperm cell contains more than 2,000 proteins and each patient's sperm varies slightly in its protein content.

Understanding the function of individual proteins in sperm cells may not only aid scientists' understanding of fertility, but can also explain the causes of miscarriages, 50 percent of which have unexplained causes. Chu also suggests that further studies of the proteins found in sperm cells will have a significant impact on our understanding of the paternal protein contribution that can have long lasting effects on future generations.


'/>"/>

Contact: Diana Chu
chud@sfsu.edu
415-405-3487
San Francisco State University
Source:Eurekalert

Related biology news :

1. New lab manual focuses on essential methods for purifying and characterizing proteins
2. Saliva proteins could help detection of oral cancer
3. St. Jude study gives new insights into how cells accessorize their proteins
4. NIH awards Argonne $800,000 to develop tool to measure distances within proteins
5. Iowa State University researcher shows proteins have controlled motions
6. Candy-coating keeps proteins sweet
7. Improved technique determines structure in membrane proteins
8. Water is designer fluid that helps proteins change shape, scientists say
9. Novel structure proteins could play a role in apoptosis
10. Scientists reveal the key mechanisms for affinity between transient binding proteins
11. Plant biologists discover unexpected proteins affecting small RNAs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/23/2017)... GENOA, Italy , May 23, 2017  Hunova, the first robotic ... and trunk, has been officially launched in Genoa, Italy ... Europe and the USA . The ... launched on the market by the IIT spin-off Movendo Technology thanks to ... view the Multimedia News Release, please click: ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
(Date:10/9/2017)... ... 09, 2017 , ... At its national board meeting in North Carolina, ... University’s Departments of Physics and Astronomy, has been selected for membership in ARCS ... for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C ... software to perform Hi-C metagenome deconvolution using their own facilities, supplementing the ...
Breaking Biology Technology: