Navigation Links
Proteins in gel
Date:6/24/2009

This release is available in German.

Several thousand test fields are tightly packed together on the tiny surface of a biochip. They permit the rapid analysis of substances, e.g. for diagnosing allergens in the blood. These biochips are already in widespread use for DNA testing. When it comes to proteins, such chips are difficult to produce. This is because the proteins have a defined three-dimensional structure by which they can interact specifically with other molecules and control biological processes. If they bind to a surface, such as on a biochip, the structure can be destroyed and the protein cannot perform its function.

Research scientists at the Fraunhofer Institute for Applied Polymer Research IAP in Potsdam-Golm have solved this problem. "We have developed a gel a network of organic molecules that we can apply to the surface of the biochip," says Dr. Andreas Hollnder, group manager at the IAP. "This gel layer is only about 100 to 500 nano-meters thick and consists mainly of water. We thus make the protein believe that it is in a solution, even though it is chemically connected to the network. It feels as if it is in its natural environment and continues to function even though it is on a biochip." Other research groups are working on similar hydrogels. The key feature of the new production technique is that it can be applied in industry, and the gel layers can be manufactured cheaply on a large scale. Usually there are two ways of producing such networks. In the first, complete polymers are chemically bound to the surface. In the second, the polymer molecules are constructed unit by unit on the surface. "Our technique is a mixture of the two known methods. We use larger molecular building blocks to build up the network on the surface," explains Falko Pippig, who is doing his doctorate on this subject at the IAP.

As the hydrogel layers are very thin, substances added from the outside very quickly reach the protein which is in and on this layer. For example, physicians can put blood or urine on the chip and diagnose illnesses. The research scientists have already developed the process fundamentals. Protein biochips could therefore become everyday items of equipment in medical laboratories the possible applications far exceed those of DNA chips.


'/>"/>

Contact: Dr. Andreas Hollaender
andreas.hollaender@iap.fraunhofer.de
49-331-568-1404
Fraunhofer-Gesellschaft
Source:Eurekalert  

Related biology news :

1. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
2. TRAPping proteins that work together inside living cells
3. Pliable proteins keep photosynthesis on the light path
4. Autopilot guides proteins in brain
5. New method for detection of phosphoproteins reveals regulator of melanoma invasion
6. New high-throughput screening technique makes probing puzzling proteins possible
7. Scripps research scientists watch as individual alpha-synuclein proteins change shape
8. Inactivity of proteins behind longer shelf life when freezing
9. Caltech and UCSD researchers shed light on how proteins find their shapes
10. Inhibiting proteins may prevent cartilage breakdown in arthritis patients
11. Tailor-made recombinant proteins in mammals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Proteins in gel
(Date:2/8/2016)... , February 8, 2016 ... platform which presents innovation for clients, comfort and ... called VoiceKey. --> Worldcore is ... innovation for clients, comfort and unbeatable security, with ... --> Worldcore is the first ...
(Date:2/4/2016)... 2016 The field of Human Microbiome ... most popular hubs of the biotechnology industry. While ... studies of human microbiota, have garnered a lot ... microbiome space has literally exploded in terms of ... report focuses on biomedical aspects of research, development, ...
(Date:2/3/2016)... 3, 2016 --> ... report "Automated Fingerprint Identification System Market by Component (Hardware ... (Banking & Finance, Government, Healthcare, and Transportation) and Geography ... market is expected to be worth USD 8.49 Billion ... 2015 and 2020. The transformation and technology evolution from ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016  Vermillion, Inc. (NASDAQ: VRML ), ... announced the formation of the Steering Committee for its ... --> Pelvic masses can present physicians and ... Once pregnancy is ruled out, pelvic masses may include ... endometriosis, benign ovarian tumors and gastrointestinal and urinary tract ...
(Date:2/11/2016)... -- Wellcentive today announced it has been selected by FamilyCare ... community care organization (CCO) with more than 130,000 ... and care management solutions and services. Wellcentive,s capabilities ... managers, analysts and care managers while providing insight ... members. Oregon . ...
(Date:2/11/2016)... Feb. 11, 2016   BioInformant announces the ... Cell Research Products, Opportunities, Tools, and Technologies – Market ... The first ... stem cell industry, BioInformant has more than a decade ... cell market, by stem cell type. This powerful 175 ...
(Date:2/10/2016)... MONTREAL , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. ... is pleased to announce that Mitsui & Co. Ltd., ... bio-based succinic acid plant, is investing an additional CDN$25 ... equity, increasing its stake from 30% to 40%.  Mitsui ... of bio-succinic acid produced in Sarnia ...
Breaking Biology Technology: