Navigation Links
Proteins: New class of materials discovered
Date:8/22/2014

This news release is available in German.

Thanks to certain helper substances, in PCFs proteins are fixated in a way so as to align themselves symmetrically, forming highly stable crystals. Next, the HZB and Fudan University researchers are planning on looking into how PCFs may be used as functional materials. Their findings are being published today in the scientific journal Nature Communications (DOI: 10.1038/ncomms5634).

Proteins are sensitive molecules. Everyone knows that at least from having boiled eggs. Under certain circumstances like immersion in boiling water they denature, losing their natural shape, and becoming hard. True, researchers have been able to handle these substances for some time now, even to the point of crystallizing them in their native state. Admittedly, though, this does require considerable effort, but it is the only way how researchers can find out the structure of these substances at high resolution. Moreover, protein crystals are extremely fragile, highly sensitive and hard to handle.

Now, for the first time ever, scientists at China's Fudan University have managed to work around these downsides by linking the protein concanavalin A to helper molecules belonging to the sugar family, and to the dye rhodamin. The concanavalin molecules that have been thus fixated tended to arrange themselves symmetrically within the helper molecule framework, forming crystals, in which the proteins achieve high stability and are intricately interconnected into a protein crystalline framework.

Developing molecular structures like these is pointless unless you know exactly how they form and what their structure looks like at the level of the atoms. During the quest for suitable experimental methods, the Shanghai researchers turned to a Chinese scientist working at the HZB for help. She called her colleagues' attention to the MX beamlines at the HZB's electron storage ring BESSY II.

"Here at the HZB, we were able to offer them our highly specialized crystallography stations the perfect venue for characterizing PCFs at high resolutions," says Dr. Manfred Weiss, one of the leading scientists working at the HZB-MX laboratory. It quickly became clear that the helper molecules even allowed the researchers to decide how powerfully they wanted them to penetrate the protein frameworks. "This gives the PCFs a great deal of flexibility and variability, which we'll always keep in mind when doing research on potential applications," says Manfred Weiss.


'/>"/>

Contact: Dr. Manfred Weiss
manfred.weiss@helmholtz-berlin.de
49-308-062-13149
Helmholtz-Zentrum Berlin fr Materialien und Energie
Source:Eurekalert  

Related biology news :

1. Erratic proteins: New insights into a transport mechanism
2. Classic Lewis Carroll character inspires new ecological model
3. SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT
4. New class of anti-arthritis drugs effectively treats multiple inflammatory diseases
5. Researchers declassify dinosaurs as being the great-great-grandparents of birds
6. Bioelectronics could lead to a new class of medicine
7. Classical monographs re-published in advanced open access
8. New class of nanoparticle brings cheaper, lighter solar cells outdoors
9. Extinct relative helps to reclassify the worlds remaining 2 species of monk seal
10. A tiny, toothy catfish with bulldog snout defies classification
11. Geniposide protects hippocampal neurons via the non-classical estrogen signaling pathway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Proteins: New class of materials discovered
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/16/2016)... 2016 The global ... reach USD 1.83 billion by 2024, according to ... Technological proliferation and increasing demand in commercial buildings, ... drive the market growth.      (Logo: ... development of advanced multimodal techniques for biometric authentication ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , ... announced today the Clinical Reach Virtual Patient Encounter CONSULT module which enables ... the physician and clinical trial team. , Using the CONSULT module, patients and physicians ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
Breaking Biology Technology: