Navigation Links
Protein 'tubules' free avian flu virus from immune recognition
Date:11/5/2008

A protein found in the virulent avian influenza virus strain called H5N1 forms tiny tubules in which it "hides" the pieces of double-stranded RNA formed during viral infection, which otherwise would prompt an antiviral immune response from infected cells, said Baylor College of Medicine researchers in an online report in the journal Nature.

Two domains or portions of the protein NS1 combine to form tiny tubules where double-stranded RNA is hidden from the immune system, said Dr. B. V. Venkataram Prasad, professor of biochemistry and molecular biology, molecular virology and microbiology at BCM and his student, Dr. Zachary A. Bornholdt (now of the Scripps Research Institute in La Jolla, California).

"Once we confirm the importance of this structural information, we should be able to design drugs to block this action," said Prasad. "There are other things the protein could do to interfere with different immune mechanisms. We don't know if this is the only mechanism or if there are others that also come into play during influenza virus infection."

The two researchers had already recognized the importance of the protein NS1 in the virulence of influenza viruses and particularly, H5N1, a form of avian flu associated with more than half the deaths in a 2004 "bird flu" outbreak that resulted in 50 human cases and 36 deaths in Vietnam, China and Thailand. In all but one case, experts ruled out human-to-human spread of the virus. In a previous report, Prasad and Bornholdt described the structure of an area of the protein called the effector domain. In this report, a series of elegant experiments designed and carried out over eight months by Bornholdt allowed the two scientists to "crystallize" the entire protein.

By doing this, they were able to determine its structure using a technique called X-ray crystallography. This technique enables scientists to determine the three-dimensional structure of proteins and other bio-molecu
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... For decades, planetary geologists have speculated that glaciers ... 2000-mile-long chasm that constitutes the Grand Canyon of ... that might have been carved by past glaciers ... observations have remained highly controversial and contested. ... College and the Freie Universitaet Berlin has identified ...
(Date:9/29/2014)... of Pangea was starting to break up and dog-sized dinosaurs ... called phytosaurs and rauisuchids were at the top of the ... predators didn,t interact much as the former was king of ... ideas are changing, thanks largely to the contents of a ... in the German journal Naturwissenschaften , Stephanie ...
(Date:9/29/2014)... Institute (DOE JGI), a DOE Office of Science ... have been selected for the 2015 Community Science ... waters, and from plant root micro-ecosystems, to the ... the CSP 2015 projects portfolio highlights diverse environments ... , "These projects catalyze JGI,s strategic shift in ...
Breaking Biology News(10 mins):Glaciers in the Grand Canyon of Mars? 2Glaciers in the Grand Canyon of Mars? 3Glaciers in the Grand Canyon of Mars? 4Glaciers in the Grand Canyon of Mars? 5Glaciers in the Grand Canyon of Mars? 6Glaciers in the Grand Canyon of Mars? 7Glaciers in the Grand Canyon of Mars? 8Glaciers in the Grand Canyon of Mars? 9Tooth buried in bone shows prehistoric predators tangled across land, sea 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 32015 DOE JGI's science portfolio delves deeper into the Earth's data mine 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 52015 DOE JGI's science portfolio delves deeper into the Earth's data mine 62015 DOE JGI's science portfolio delves deeper into the Earth's data mine 72015 DOE JGI's science portfolio delves deeper into the Earth's data mine 82015 DOE JGI's science portfolio delves deeper into the Earth's data mine 9
... 2012 Millions of people worldwide suffer from a ... triggered by nerve damage. Precisely how this pain persists ... ineffective. But a team led by scientists from The ... metabolomics, has now discovered a major clue: dimethylsphingosine (DMS), ...
... researchers of Hospital del Mar and its research institute, ... pharmacological resistance to cancer. This new mechanism is a ... receptor) causing resistance to treatment using a drug called ... The study proves that, both in lab models ...
... work with engines traveling on straight tracks, a team ... Oxford have successfully used DNA building blocks to construct ... tracks with multiple switches. The findings, published in the ... Nanotechnology , are expected to lead to further developments ...
Cached Biology News:Scripps Research scientists provide new understanding of chronic pain 2Scripps Research scientists provide new understanding of chronic pain 3Identified a cause of resistance to colon cancer treatment 2
(Date:9/29/2014)... (PRWEB) September 30, 2014 Each ... burn injuries require medical attention. In the military, ... serious complications to battlefield medical care. More than ... and Afghanistan. Burn wounds heal slowly, remain inflamed ... be excessive, physically debilitating and functionally damaging. While ...
(Date:9/29/2014)... 29, 2014 Research and Markets  has ... by Product & Services, End-User , Application - Global ... The global oligonucleotide synthesis market is expected ... in 2014, growing at a CAGR of 9.8% from ... categorized on the basis of products and services, applications, ...
(Date:9/29/2014)... 29, 2014 Research and Markets  has ... Gas Analyzer, and Gas Chromatograph Market by Type , ... Global Trends & Forecast to 2013 - 2020" ... analyzer is a process analytical instrument that provides chemical ... redefined the way by which companies carry out their ...
(Date:9/29/2014)... 2014  Atlas Venture, an early stage venture capital ... today announced that Jason Rhodes , President and ... ), is joining the firm,s life sciences investing team ... At Atlas, Rhodes will work closely with the life ... accomplished record in company creation, deal making and venture ...
Breaking Biology Technology:Faster Healing with Fewer Scars 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 2Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 4Atlas Venture Names Jason Rhodes, Veteran Investor and President and CFO of Epizyme, As Partner on Life Sciences Investing Team 2
... accuracy: DNA vaccines that home in on DCs are ... develop new vaccines against infectious diseases is DNA vaccination. ... vaccine, the body converts the information in the DNA ... However, current DNA vaccines induce relatively weak immune responses ...
... UK, 6 March 2008 Elsevier, the world-leading ... and services, announced today Hybrid Materials 2009: The ... which will take place in Tours, France, 15-19 ... has experienced a 14% annual growth in published ...
... DNDN ) will release its fourth quarter financial results on,Thursday, March ... PT; 11:00 a.m. ET to review fiscal year 2007 financial results,and ... follows:, Time: 11:00 AM ... March 13, 2008 Dial-in: 1-877-548-7901 (domestic) or +1-719-325-4844 ...
Cached Biology Technology:JCI online early table of contents: March 6, 2008 2JCI online early table of contents: March 6, 2008 3JCI online early table of contents: March 6, 2008 4Hybrid materials: Exciting interdisciplinary field offering future solutions for industry 2-Dendreon to Hold Conference Call on Thursday, March 13, 2008 at 11:00 AM ET- 2
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap, packed in double bag. (20/ca) Packaging: ...
Four siRNAs targeting your gene of interest, providing gene silencing with 100% satisfaction guaranteed High knockdown potency , High specificity for minimal off-target effects , Flexible siR...
... isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ... both a double bond at 13,14 ... at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl ... potential impurity in most commercial preparations ...
... CLS number is a new product number, ... If showing no availability yet, please order ... contact customer service for assistance. ... Dim: surface area 21 cm 2 ...
Biology Products: