Navigation Links
Protein that promotes cancer cell growth identified
Date:7/24/2009

e-blot assays to demonstrate that reconstituting the Caspase-8 deficient cells with Caspase-8 with mutations in the RXDLL domain did not result in EGF signaling. This suggests that Caspase-8 mediates signaling through the RXDLL domain. The scientists had previously shown in another study that Caspase-8 associates with Src, a protein known to be involved in cancer cell proliferation. In this study they showed that interruption in this association disrupts EGF signaling indicating that Caspase-8 exerts EGF signaling through Src.

Cancer results from excessive cell division and reduced cell death. A number of cell death proteins are missing from human tumors, allowing cancer cells to ignore the cues that keep their growth in check. Cells that can evade apoptosis have a clear growth advantage. Because Caspase-8 is involved in programmed cell death, it would seem that reducing Caspase-8 in cancer cells would provide a growth advantage. However, this is rarely observed in human cancers.

By providing a more complete understanding of the molecular mechanisms involved in cancer cell proliferation and migration, these results point to Caspase-8 as a novel therapeutic intervention point for treating multiple types of human cancers.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sticky protein helps reinforce fragile muscle membranes
2. Plant protein doorkeepers block invading microbes, study finds
3. Protein can help cells or cause cancer, Purdue researcher finds
4. Plant protein doorkeepers block invading microbes, study finds
5. Structural biology scores with protein snapshot
6. Proteins in gel
7. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
8. Researchers observe single protein dimers wavering between two symmetrically opposed structures
9. Cancer-causing protein can also help fight the tumors it causes
10. TRAPping proteins that work together inside living cells
11. Protein regulates movement of mitochondria in brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Calif. (Sept. 17, 2014) A rare genetic disorder known ... to a recent joint investigation by researchers at San ... Diego. In addition to suggesting better treatment options for ... clues into the genetic underpinnings of autism., Jacobsen syndrome ... National Institutes of Health. It occurs in a person ...
(Date:9/17/2014)... and their environmental impact recently scored a major win. ... on the bags, and Governor Jerry Brown is expected ... not yielding without a fight, according to an article ... newsmagazine of the American Chemical Society. , Alexander Tullo, ... campaign logged its first small victory in 1990 when ...
(Date:9/17/2014)... in Biomedical Informatics at IMIM (Hospital del Mar Medical ... (UPC) have recently published a study in eLife ... important role in the evolution of new proteins, some ... be discovered., Ribosomes produce proteins from the instructions found ... human genome is RNA containing information for the synthesis ...
Breaking Biology News(10 mins):A link between Jacobsen syndrome and autism 2Parts of genome without a known function may play a key role in the birth of new proteins 2
... African sanctuaries carry drug-resistant, human-associated strains of the bacteria ... chimpanzees could spread to endangered wild ape populations if ... study shows. The study by veterinarians, microbiologists and ... sequencing technology of bacterial genomes used in hospitals to ...
... forget-me-nots have been added to Flora of New Zealand . ... Island during an expedition led by Dr. Carlos A. Lehnebach. These ... the open access journal PhytoKeys . The expedition ... at the Museum of New Zealand Te Papa Tongarew a ...
... faces far greater change and risk of large-scale extinctions than ... the world,s leading marine scientists has warned. The researchers ... UK have compared events which drove massive extinctions of sea ... taking place in the seas and oceans globally today. ...
Cached Biology News:Sanctuary chimps show high rates of drug-resistant staph 2No ordinary forget-me-nots 2Sea life 'facing major shock' 2Sea life 'facing major shock' 3
(Date:9/18/2014)... Sept. 18, 2014   Sigma-Aldrich Corporation ... has entered into a new gene editing partnership ... Vector Core. Under the partnership, Sigma-Aldrich will provide ... design consultation, and dedicated gene editing bioinformaticians. ... editing-based research at the U-M Medical School. One ...
(Date:9/18/2014)... 2014 SeqLL Inc., the owner ... announced today the closing of a $1M Series-A ... Genomic Diagnostic Technologies, will increase the power of ... Founded in March 2013 by Daniel Jones, a ... Helicos BioSciences, SeqLL has continued to offer Helicos’ ...
(Date:9/18/2014)... lab can be pretty expensive. Now a team led ... an open-source library of designs that will let scientists ... equipment: the syringe pump. , Syringe pumps are used ... delivery or mixing chemicals in a reaction. They can ... Joshua Pearce and his team of Michigan Tech students ...
(Date:9/18/2014)... a new microscopy technology that allows them to ... resolution. , Dubbed "Complementation Activated Light Microscopy" (CALM), ... an order of magnitude finer than conventional optical ... biomolecules at the nanometer scale. , In a ... Communications , the researchers behind CALM used it ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Doing science just got cheaper -- and faster 2Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2
... to Screen Donated Blood for Hepatitis B, as well ... and Semi-Automated Instrument Systems -, SAN DIEGO, Aug. ... that the US Food and Drug Administration,(FDA) has approved ... to screen donated blood for the hepatitis B,virus (HBV). ...
... Stock Exchange Symbol: MS, - Milestone triggers ... - EDMONTON, Aug. 13 /PRNewswire-FirstCall/ - BioMS ... treatment of multiple sclerosis (MS), today,announced that the ... trial has conducted the scheduled interim analysis of ...
... Mentice, Inc. and MATC have,forged a relationship that ... multiple,and mutually beneficial projects to further advance the ... throughout North America., Mentice,s Procedicus VIST Simulator ... physician to gain exposure to routine,and sophisticated procedures. ...
Cached Biology Technology:FDA Grants Full Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay 2FDA Grants Full Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay 3FDA Grants Full Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay 4BioMS Medical announces positive interim analysis on phase III trial of dirucotide (MBP8298) for multiple sclerosis 2BioMS Medical announces positive interim analysis on phase III trial of dirucotide (MBP8298) for multiple sclerosis 3BioMS Medical announces positive interim analysis on phase III trial of dirucotide (MBP8298) for multiple sclerosis 4Mentice, Inc. and the Milwaukee Area Technical College (MATC) Announce Their Partnership in the Area of Procedural Medical Simulation 2
... an inhibitor of caspase-3/7 ... of inhibitor required to ... be determined empirically for ... inhibitor is sufficient to ...
...
SNARE associated protein snapin, clone MGC:2717...
Human OSCAR MAb (Clone 259501)...
Biology Products: