Navigation Links
Protein surfaces defects act as drug targets
Date:7/30/2013

New research shows a physical characterisation of the interface of the body's proteins with water. Identifying the locations where it is easiest to remove water from the interface of target proteins could constitute a novel drug design strategy. The candidate drugs would need to be engineered to bind at the site of the protein where interfacial water is most easily dislodged. These findings, based on the work of Mara Beln Sierra from the National University of the South, in Bahia Blanca, Argentina and colleagues, were recently published in EPJ E.

The challenge is to describe the protein-water interface without a nanoscale model for water. Previous research tended to regard water as a continuum medium even at interfaces. However, these are inadequate for nanometric scale events occurring on the protein surfaces. Instead, the authors prefer a discrete model describing water molecules' partial confinement on the proteins' surface.

Beln Sierra and colleagues pursued a novel strategy for correlating interfacial water mobility with so-called packing defects in the protein structure. Proteins typically fold in ways that will keep part of their interface with water dry, in order to carry out their biological function. However, some of the paper's authors have previously discovered that the protein's water seal typically has some defects, called dehydrons. These are like crevices on the protein surface permitting access to water molecules.

The water molecules become heated up because they cannot interact with their neighbours as fully as they do in bulk water. These interfacial water molecules are thus unstable and easily expelled. The authors' findings thus pinpoint the exact location of these unstable water molecules. This, in turn, could be useful in selecting future drug candidates that would dislodge these water molecules upon association with the protein on the defect sites.


'/>"/>

Contact: Sophia Grein
sophia.grein@springer.com
49-622-148-78414
Springer
Source:Eurekalert

Page: 1

Related biology news :

1. Natural pest control protein effective against hookworm: A billion could benefit
2. New approach to protecting prion protein from altering shape
3. Protein targeted for cancer drug development is essential for normal heart function
4. Scientists decipher cellular roadmap of disease-related proteins
5. Toronto team IDs proteins key in stem cell production
6. Toronto team ID proteins key in stem cell production
7. Low levels of toxic proteins linked to brain diseases, study suggests
8. Liver protein crucial for pregnancy
9. MARC travel awards announced for the 27th Protein Society Symposium 2013
10. Study identifies protein that contributes to cognitive decline in Alzheimers
11. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017 Vigilant Solutions ... serving law enforcement agencies, announced today the appointment of ... director of public safety business development. Mr. ... enforcement experience, including a focus on the aviation transportation ... most recent position, Mr. Sheridan served as the Aviation ...
(Date:3/9/2017)... , Australia , March 9, 2017 ... data at the prestigious World Lung Imaging Workshop at ... Andreas Fouras , was invited to deliver the latest ... medicine. This globally recognised event brings together leaders at ... the latest developments in lung imaging. ...
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
Breaking Biology News(10 mins):
(Date:3/20/2017)... (PRWEB) , ... March 20, ... ... substances that interfere with the ability of endogenous hormones to regulate homeostasis ... ligand binding activity (antagonists), EDCs produce adverse reproductive, neurological, proliferative, and immunological ...
(Date:3/20/2017)... ... March 20, 2017 , ... Existing methods using LC-MS/MS suffer ... to reduce the impact on instrumentation. ICP-MS is a robust and specific analytical ... , This presentation will discuss the pros and cons of using LC-ICP-MS for ...
(Date:3/20/2017)... ... March 20, 2017 , ... Park Systems, a leader in Atomic Force Microscopy ... 24, 2017 from 5-7pm at their Santa Clara facility that will include craft beer ... Researcher, Dr. Tae-Gon Kim. , Dr. Tae-Gon Kim, Senior researcher at imec Belgium and ...
(Date:3/20/2017)... , March 20, 2017  Attorney Advertising -- Bronstein, Gewirtz ... purchasers of the BioAmber Inc. ("BioAmber" or the "Company") (NYSE: ... information and assist the investigation by visiting the firm,s site: ... BioAmber and certain of its officers and/or directors have violated ... 1934. ...
Breaking Biology Technology: