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Protein structure determined in living cells
Date:3/5/2009

a 5-6 hours without supply of oxygen and nutrients. Gntert and his colleagues compensated for the concomitant drastic reduction of the measurement time by computational reconstruction of the complete spectrum. Then, they calculated a detailed three-dimensional structure of the protein within E. coli cells using software that was developed in their research group.

The structure determination of proteins by in-cell NMR spectroscopy opens new avenues to investigate at atomic resolution how proteins participate in biological processes in living systems. In-cell NMR spectroscopy advances our understanding of the molecular basis of life, and can contribute to the development of new, better targeted pharmaceuticals.


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Contact: Peter Guentert
guentert@em.uni-frankfurt.de
49-697-982-9621
Goethe University Frankfurt
Source:Eurekalert

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