Navigation Links
Protein structure: Peering into the transit pore
Date:2/7/2014

The lipid-rich membranes of cells are largely impermeable to proteins, but evolution has provided a way through in the form of transmembrane tunnels. A new study shows in unmatched detail what happens as proteins pass through such a pore.

Every cell is surrounded by a surface membrane and contains internal compartments bounded by membranes. Almost one-third of all proteins synthesized in cells must pass through these membranes or be incorporated into them in order to fulfil their functions. However, the fat-rich nature of membranes makes it impossible for most proteins to percolate through them directly. Therefore, biological membranes contain so-called protein-conducting channels, molecular pores through which proteins can pass. "Structural investigations have already provided clues to how proteins are inserted into the membrane and then drawn through it like a length of thread to emerge on the other side," says Professor Roland Beckmann of the Gene Center of Ludwig-Maximilians-Universitaet (LMU) in Munich. "However, conclusive proof for these mechanisms has been lacking until now."

Protein-conducting channels are known to be shaped like an hour-glass, consisting of two cones connected by a narrow central constriction. In the inactive form, the constriction is blocked by a plug that protrudes from the side-wall. Presumably, if a protein is to cross the membrane, the channel must be opened to provide a continuous aqueous environment for its passage. If, on the other hand, a protein is to be inserted within the membrane itself, it must emerge from a lateral opening within the tunnel.

Imaging the crucial transition

"Up until now, it had not been possible to characterize these structural transitions with the required spatial and temporal resolution," Beckmann says. Now he and his colleagues have, for the first time, succeeded in isolating transitional forms of the active channel, and elucidating their three-dimensional struct
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein synthesis and chance
2. Designer proteins provide new information about the bodys signal processes
3. The Protein Society announces the selection of 2 Protein Science Best Paper speakers
4. Researchers tune in to protein pairs
5. FASEB announces 2014 Science Research Conference: Protein Folding in the Cell
6. FASEB announces 2014 SRC: Protein Phosphorylation, Cellular Plasticity & Signaling Rewiring
7. FASEB announces 2014 SRC: Protein Interactions, Structures, Technologies & Networks
8. High-protein diets, like the Dukan diet, increase the risk of developing kidney disease
9. Overexpression of splicing protein in skin repair causes early changes seen in skin cancer
10. Next-gen reappraisal of interactions within a cancer-associated protein complex
11. Researchers pursuing arthritis protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Researchers at the Catalan Institute of Oncology-Bellvitge Biomedical ... identified 5 genes differentially expressed in normal accompanying ... could be used to classify colorectal tumors, predict ... appropriate clinical decisions to prevent relapses. , ... most common in our population considering both sexes. ...
(Date:9/17/2014)... decades of decline, grasses have returned to some once-denuded ... marsh in those places seems healthy again, but a ... the marsh coastal protection remains diminished. , ... hasn,t come back," said ecologist Mark Bertness, professor of ... in the journal Biological Conservation . "The metric ...
(Date:9/17/2014)... including MRSA and MSSA could be curbed by ... the scaly surface of shark skin, according to ... Antimicrobial Resistance and Infection Control . , The ... spread of human disease bacteria through touching, sneezes ... arrangement of ridges formulated to resemble shark skin. ...
Breaking Biology News(10 mins):Five genes to predict colorectal cancer relapses 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Sharks' skin has teeth in the fight against hospital superbugs 2
... of a shift in U.S. demographics and importance of ... how do those growing toward majority acquire representation in ... that mentor and move minorities forward to majorities in ... that is gaining traction, said Castillo-Chavez, one of a ...
... Bunions bothering you? How about lower back pain, or impacted ... millennia to walk on two legs, grow larger brains and ... experienced some negative consequences on our way to becoming the ... But keeping our evolutionary history in mind can help us ...
... simultaneously to that which is visible and can be subjectively ... hunger is known as ,hidden hunger, or chronic malnutrition. Every ... hidden hunger before they are five years old. Year ... of starvation, which is responsible for the deaths of millions ...
Cached Biology News:Mentoring models to move minorities to majorities in STEM 2Mentoring models to move minorities to majorities in STEM 3Is there a Neanderthal in the house? 2Malnutrition -- Living hungrily ever after 2
(Date:9/18/2014)... Leatherwood Plastics has selected Vycom’s ... stay competitive in the semiconductor, clean room and ... impact product quality and productivity, according to Dwight ... in 1980 in Lewisville, TX, Leatherwood Plastics ... left the business. Much of Leatherwood’s equipment building ...
(Date:9/18/2014)... 2014 /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ONTY ... but separate underwritten offerings of 10,000,000 shares of its ... $2.00 per share, for expected gross proceeds of $20 ... Preferred Stock at a price to the public of ... million. Each share of Series A Convertible Preferred Stock ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 SeqLL ... Sequencing (tSMS™) technology, announced today the closing of ... investment, led by Genomic Diagnostic Technologies, will increase ... diagnostic applications. , Founded in March 2013 by ... Bioinformatics Analyst at Helicos BioSciences, SeqLL has continued ...
(Date:9/18/2014)... at USC have developed a new microscopy technology ... living animals at higher-than-ever resolution. , Dubbed "Complementation ... imaging resolutions that are an order of magnitude ... into the behavior of biomolecules at the nanometer ... 18 by Nature Communications , the researchers ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2
Peptide-affinity Purified Polyclonal Antibody to Olfactory Receptor, Family 2, Subfamily H, Member 3...
... from balances and scales with RS232 ports and ... If you can type the weight into the ... Simple to use parser extracts required data ... user information , Collect data at timed intervals ...
... XL provides balance data collection and automation that ... integration with Microsoft Excel , Pre-configured library ... , New balances can be added and configured ... from multiple balances into one spreadsheet ...
...
Biology Products: