Navigation Links
Protein sharpens salmonella needle for attack
Date:5/15/2014

e Salmonella completely loses its capacity for intracellular replication and to spread throughout the organism. Further investigations finally brought the scientists from Basel onto the right track. The protein EIIAGlc docks onto the injection apparatus in the bacterium, stabilizes it and finally activates the release of the toxins. "We can clearly demonstrate that the activation of the secretion system is the main function of the protein EIIAGlc, while the many other described metabolic functions play a minor role in the occurrence of illness", says Bumann bringing his findings to the point.

Target molecule for antibiotic treatment

It is estimated that each year about 16 million people worldwide contract a life-threatening Salmonella infection that affects the whole organism. The spread of the bacteria in the host is highly dependent on the functional capacity of the injection system. "In EIIAGlc, we have found a new potential therapeutic target", says Bumann. By inhibiting the protein, one could strategically put the infection apparatus out of action. As this injection needle is primarily found in pathogens, infections could be effectively and specifically fought without harming the natural intestinal microflora.


'/>"/>
Contact: Katrin Bühler
Katrin.Buehler@unibas.ch
University of Basel
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Protein Data Bank: 100,000 structures
2. New technique tracks proteins in single HIV particle
3. Key protein, FABP5, enhances memory and learning
4. Killing Kindlin-3 to cure breast cancer: Blood protein implicated
5. Consuming high-protein breakfasts helps women maintain glucose control, MU study finds
6. Scientists identify critical new protein complex involved in learning and memory
7. Protein expression gets the heart pumping
8. A protein required for integrity of induced pluripotent stem cells
9. Mutant protein in muscle linked to neuromuscular disorder
10. New meta-analysis builds on the power of whey protein for improved body composition
11. UCLA scientist awarded $3 million to fund research into proteins affecting the kidney
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein sharpens salmonella needle for attack
(Date:8/27/2014)... that exists as five strains, none of which have ... the Sudan ebolavirus (SUDV). Although not the strain currently ... as recently as 2012. In a new study appearing ... now report a possible therapy that could someday help ... Sidhu, Jonathan Lai and colleagues explain that about 50-90 ...
(Date:8/27/2014)... or abandoned each year in U.S. waters and become ... catch fish, crabs, and other species such as turtles. ... the watermen who depend on the resources--losses that are ... , The report, published in the Marine Pollution ... examine the derelict fish trap problem, and so-called "ghost ...
(Date:8/27/2014)... has shown that piglets can be weaned later with ... outcome of the study at the University,s Roseworthy campus, ... is an important finding for pig producers. It allows ... production. , "Sows don,t usually start their oestrous cycles ... piglets have been weaned," says Ms Alice Weaver, PhD ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2Piglet weaning age no bar to litter frequency 2
... The New York Stem Cell Foundation (NYSCF) Research Institute in ... Mount Sinai (ISMMS) successfully generated a stem cell model of ... identified fourteen genes that may be implicated in the disease ... inflammation may play in the brain of Alzheimer,s patients. ...
... 2014)- The leatherback turtle in the Pacific Ocean is one ... has declined by more than 90 percent since 1980. One ... set thousands of hooks in the ocean to catch fish, ... technology, researchers are now able to predict where fisheries and ...
... with a heart defect such as a hole in the heart, ... quickly and safely secure devices inside the heart. Sutures take too ... tissue, and currently available clinical adhesives are either too toxic or ... or under dynamic conditions, such as in a beating heart. ...
Cached Biology News:Stem cell research identifies new gene targets in patients with Alzheimer's disease 2Stem cell research identifies new gene targets in patients with Alzheimer's disease 3GPS traffic maps for leatherback turtles show hotspots to prevent accidental fishing deaths 2GPS traffic maps for leatherback turtles show hotspots to prevent accidental fishing deaths 3Bio-inspired glue keeps hearts securely sealed 2Bio-inspired glue keeps hearts securely sealed 3
(Date:8/27/2014)... -- Research and Markets  has announced the ... Polymer, Food & Beverage, Personal Care & Pharmaceutical) ... report to their offering. Lactic acid ... carbon atom. The main applications of lactic acid ... personal care product, and pharmaceutical industries. Lactic ...
(Date:8/27/2014)... “We are honored to be named to this ... of Radiant Sage. “We are offering truly ground-breaking clinical ... market to a different level. We are enabling ... and effectively manage the massive amounts of medical imaging ... read by trained physicians. Being recognized by technology industry ...
(Date:8/27/2014)... Flagship Biosciences LLC, a leading provider ... pharmaceutical and medical device industries, has announced a laboratory ... company has consolidated its histology and tissue analysis operations ... CO, just north of Denver. The new addresses ... Ave., Suite 100, Westminster, CO 80021 , Tissue Image ...
(Date:8/27/2014)... -- ARCH Venture Partners, one of the largest U.S. ... seed and early-stage advanced technology companies, today announced ... than $400 million in subscriptions. ARCH Venture Fund ... more than $150 million. "The enthusiasm ... of our approach to finding and funding new ...
Breaking Biology Technology:Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Flagship Biosciences Announces Relocation and Expansion 2Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3
... "We Want to Double our Sales Within Three Years", ... in,sales of EUR 3.4 million to EUR 17 million, ... the path of significant growth in 2007. "We want ... years," states CEO Nikolaus Uleer.,With the construction of the ...
... 10 Arena Pharmaceuticals,Inc. (Nasdaq: ARNA ) today ... 2007 after the NASDAQ Global Market closes on Wednesday,October ... and,Chief Executive Officer, and Robert E. Hoffman, Arena,s Vice ... call at 5:00,p.m. Eastern Time (2:00 p.m. Pacific Time) ...
... (ED) hold a,critical key in improving acute coronary ... all the tools that you need to improve ... to Better Myocardial,Infarction Outcomes: Emergency Departments Hold the ... experts, Deborah Diercks, MD; James Hoekstra, MD; and,Charles ...
Cached Biology Technology:Dr. Suwelack Skin & Health Care: New Product in the FDA Certification Process 2Arena Pharmaceuticals to Report Third Quarter 2007 Financial Results and to Host Conference Call and Webcast on Wednesday, October 17, 2007 2Arena Pharmaceuticals to Report Third Quarter 2007 Financial Results and to Host Conference Call and Webcast on Wednesday, October 17, 2007 3UPDATE: Free CME-certified Webcast: Opening the Door to Better Myocardial Infarction Outcomes: Emergency Departments Hold the Key 2UPDATE: Free CME-certified Webcast: Opening the Door to Better Myocardial Infarction Outcomes: Emergency Departments Hold the Key 3
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
EnzChek cellulase substrate *blue fluorescent, 339/452...
... Kb RNA Ladder is suitable for sizing single-stranded RNA ... or formaldehyde agarose gels. The ladder consists of nine ... 4 6 8 and 10 kb) to simplify size ... the other bands allowing easy orientation and identification of ...
...
Biology Products: