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Protein sharpens salmonella needle for attack
Date:5/15/2014

e Salmonella completely loses its capacity for intracellular replication and to spread throughout the organism. Further investigations finally brought the scientists from Basel onto the right track. The protein EIIAGlc docks onto the injection apparatus in the bacterium, stabilizes it and finally activates the release of the toxins. "We can clearly demonstrate that the activation of the secretion system is the main function of the protein EIIAGlc, while the many other described metabolic functions play a minor role in the occurrence of illness", says Bumann bringing his findings to the point.

Target molecule for antibiotic treatment

It is estimated that each year about 16 million people worldwide contract a life-threatening Salmonella infection that affects the whole organism. The spread of the bacteria in the host is highly dependent on the functional capacity of the injection system. "In EIIAGlc, we have found a new potential therapeutic target", says Bumann. By inhibiting the protein, one could strategically put the infection apparatus out of action. As this injection needle is primarily found in pathogens, infections could be effectively and specifically fought without harming the natural intestinal microflora.


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Contact: Katrin Bühler
Katrin.Buehler@unibas.ch
University of Basel
Source:Eurekalert  

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