Navigation Links
Protein sharpens salmonella needle for attack
Date:5/15/2014

A tiny nanoscale syringe is Salmonella's weapon. Using this, the pathogen injects its molecular agents into the host cells and manipulates them to its own advantage. A team of scientists at the Biozentrum of the University of Basel demonstrate in their current publication in Cell Reports that a much investigated protein, which plays a role in Salmonella metabolism, is required to activate these needles and makes the replication and spread of Salmonella throughout the whole body possible.

The summer months are the prime time for Salmonella infections. Such an infection is caused by the ingestion of contaminated food, for instance ice cream or raw eggs, and can cause severe diarrhea. Salmonella can even cause life-threatening illnesses such as typhoid fever.

For several years, Prof. Dirk Bumann, from the Biozentrum of the University of Basel, has been studying the infection mechanisms of Salmonella. Together with his team, he has discovered that the bacterial protein EIIAGlc is not only responsible for the uptake of nutrients, which was previously known, but also plays a central role in Salmonella colonizing the host organism.

New function discovered for well known protein

Salmonella possesses a sophisticated injection apparatus, the type III secretion system. With this molecular syringe, it injects toxins directly into the host cells. These toxins manipulate host cell processes to create optimal growth conditions for the bacteria in hiding. Unforeseen, Bumann and his team uncovered an important teammate in the infection process, the protein EIIAGlc. The protein was already known for its many functions in bacterial metabolism, such as in the uptake of sugars molecules.

The researchers' attention was attracted by the fact that when EIIAGlc is defective Salmonella completely loses its capacity for intracellular replication and to spread throughout the organism. Further investigations finally brought the scientists from Basel onto the right track. The protein EIIAGlc docks onto the injection apparatus in the bacterium, stabilizes it and finally activates the release of the toxins. "We can clearly demonstrate that the activation of the secretion system is the main function of the protein EIIAGlc, while the many other described metabolic functions play a minor role in the occurrence of illness", says Bumann bringing his findings to the point.

Target molecule for antibiotic treatment

It is estimated that each year about 16 million people worldwide contract a life-threatening Salmonella infection that affects the whole organism. The spread of the bacteria in the host is highly dependent on the functional capacity of the injection system. "In EIIAGlc, we have found a new potential therapeutic target", says Bumann. By inhibiting the protein, one could strategically put the infection apparatus out of action. As this injection needle is primarily found in pathogens, infections could be effectively and specifically fought without harming the natural intestinal microflora.


'/>"/>
Contact: Katrin Bühler
Katrin.Buehler@unibas.ch
University of Basel
Source:Eurekalert  

Related biology news :

1. Protein Data Bank: 100,000 structures
2. New technique tracks proteins in single HIV particle
3. Key protein, FABP5, enhances memory and learning
4. Killing Kindlin-3 to cure breast cancer: Blood protein implicated
5. Consuming high-protein breakfasts helps women maintain glucose control, MU study finds
6. Scientists identify critical new protein complex involved in learning and memory
7. Protein expression gets the heart pumping
8. A protein required for integrity of induced pluripotent stem cells
9. Mutant protein in muscle linked to neuromuscular disorder
10. New meta-analysis builds on the power of whey protein for improved body composition
11. UCLA scientist awarded $3 million to fund research into proteins affecting the kidney
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein sharpens salmonella needle for attack
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... SAN FRANCISCO , June 23, 2016   ... it has secured $1 million in debt financing from ... to ramp up automation and to advance its drug ... for its new facility. "SVB has been ... goes beyond the services a traditional bank would provide," ...
(Date:6/23/2016)... , ... June 23, 2016 , ... STACS DNA Inc., ... Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field ... DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding ...
Breaking Biology Technology: