Navigation Links
Protein regulates enzyme linked to Alzheimer's disease

BOSTON (May 25, 2010) Researchers at Tufts University School of Medicine have zeroed in on a protein that may play a role in the progression of Alzheimer's disease. The team found that increasing levels of the protein (called GGA3) prevented the accumulation of an enzyme linked to Alzheimer's. The strategy may lead to new treatments for the neurodegenerative disease. The findings were published online May 18 in the Journal of Biological Chemistry.

People with Alzheimer's disease typically have higher levels of an enzyme called BACE1 in their brains. BACE1 produces a toxin that researchers have pinpointed as a cause of Alzheimer's, and now, researchers have found a way to prevent BACE1 from accumulating in the brain.

"We have identified the protein that takes this enzyme to the cell's garbage disposal for removal. Increasing levels of the protein allows more of the enzyme to be eliminated, possibly preventing the high levels seen in people with Alzheimer's disease," said senior author Giuseppina Tesco, MD, PhD, assistant professor in the department of neuroscience at Tufts University School of Medicine (TUSM).

Tesco and colleagues previously discovered that levels of the GGA3 protein were significantly lower in the brains of Alzheimer's patients than those free of the disease. In the current in vitro study, the team also found, unexpectedly, that the GGA3 protein must bind with the regulatory protein ubiquitin in order to lower enzyme levels.

"This insight advances our understanding of the molecular mechanisms of Alzheimer's disease. We hope that our approach will lead to new therapies that treat and prevent Alzheimer's, which currently affects as many as 5.1 million Americans," said Tesco. Tesco is also a member of the neuroscience program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts, leading the Alzheimer's disease research laboratory.

Alzheimer's disease is a progressive neurodegenerative disorder that results in loss of memory and cognitive function. It is the most common cause of dementia in adults age 65 and over. Currently, prescription drugs are available that may slow the progression of the disease, but none of these medications are effective in stopping the progression of Alzheimer's.


Contact: Siobhan Gallagher
Tufts University, Health Sciences

Related biology news :

1. Intracellular express -- why transport protein molecules have brakes
2. Protein power for Jack and the beanstalk
3. Study finds protein that plays key role in early embryonic development
4. Jefferson scientists identify a new protein involved in longevity
5. Dietary protein may reduce hip fractures in the elderly
6. Glaucomas unique protein expression could enhance diagnosis and treatment
7. AAPS presents therapeutic protein drug interactions workshop
8. Synthetic enzymes could help ID proteins
9. New data on the regulation of a protein that is altered in all cancers
10. Research pinpoints action of protein linked to key molecular switch
11. Hopkins researchers put proteins right where they want them
Post Your Comments:
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... 2017 According to a new market research report ... Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region ... expected to grow from USD 14.30 Billion in 2017 to USD 31.75 ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... today announces publication of a United States multicenter, prospective clinical study that ... disposable, point-of-care diagnostic test capable of identifying clinically significant acute bacterial and ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board meeting ... I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space ... membership in ARCS Alumni Hall of Fame . ASTER Labs is a ...
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology: