Navigation Links
Protein provides link between calcium signaling in excitable and non-excitable cells
Date:10/1/2010

A calcium-sensing protein, STIM1, known to activate store-operated calcium channels has been found to also inhibit voltage-operated calcium channels, according to researchers at Temple University.

The researchers published their findings, The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and Cav1.2 Channels, in the Oct. 1 issue of Science magazine (www.sciencemag.org).

Calcium, not just important for bones and teeth, is a universal signaling agent that is pivotal in controlling a wide range of cell functions including fast muscle and nerve responses and slower response such as cell division, cell growth, apoptosis or programmed cell death and even fertilization of eggs.

Calcium is stored in cells and rapidly released out and pumped back to control things like contraction of muscle or the triggering of immune cells said Donald Gill, Professor and Chair of Biochemistry in Temple's School of Medicine and the study's lead researcher.

He said that the STIM1 protein, which he helped discover about 5 years ago, was found to play a major role in sensing the low levels of calcium in cell stores and activating the highly selective Orai calcium channel to allow calcium to flow back into the cell.

"We thought it seemed crazy that the STIM1 protein goes through this incredible dance but the only thing it does is activate the Orai channel," he said. "It seemed difficult to believe it only had this one specific function."

About two years ago, Gill and his colleagues noticed that in addition to activating the Orai channel to allow calcium to trickle back into the cell stores, STIM1 was also inhibiting the function of the crucial and widespread voltage-operated calcium channel, known as the L-typechannel.

"At the time, we thought only electrically excitable cells, like cardiac, neural and skeletal cells, had L-type (or long-lasting) calcium channels," he said.
'/>"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
(Date:11/21/2014)... YORK , Nov. 19, 2014  Earlier this ... at New York College, and one of the most ... biosensor signals that are transmitted from Smartphones to third ... were Smartphones and has one of the earliest known ... discussing its usage in the military, child care, elder ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... a part of the National Institutes of Health ... million to fund three new Institutional Development Awards ... concentrating on one general area of research ... research infrastructure. The IDeA program is designed to ...
... altering the Earths chemistry. Many of societys most pressing ... from human activities that disrupt natural chemical cycles. Moving ... reversing actions that have such a huge impact on ... of the Institute of Ecosystem Studies, Dr. William H. ...
... -- Three researchers at the Albert Einstein College of ... Research Foundation (BCRF). Drs. Thomas Rohan, Susan Horwitz and ... its ongoing effort to support the advancement of breast ... is its mission, which is to achieve prevention and ...
Cached Biology News:NIH grants $33 M in institutional development awards to 3 states 2Biogeochemistry -- A window into the Earth's ecological health 2Einstein researchers receive grants totaling $700,000 for innovative breast cancer research 2
(Date:12/13/2014)... Taiwan (PRWEB) December 12, 2014 Trend ... indicators in overall global economic growth, Eugene Arthurs, CEO ... photonics , said in a featured talk at OPTIC ... December at the National Chung Hsing University in Taichung. ... being integrated into future energy supplies and soon to ...
(Date:12/13/2014)... New York, New York (PRWEB) December 13, 2014 ... expansion of its global network and Cold Chain capabilities, ... new Control Tower in Paris, France, to serve Life ... brand new facility equipped with a controlled-ambient warehouse, will ... in-transit storage for vaccines and investigational drugs, patient-clinical specimens, ...
(Date:12/13/2014)... ROCHESTER, N.Y. , Dec. 12, 2014 ... engaged in the discovery and development of ... neurodegenerative diseases, today announced publication of a ... microglia, and inhibits remyelination in neurodegenerative disease" ... journal Neurobiology of Disease*.  The publication highlights ...
(Date:12/12/2014)... Graphite Metallizing Corporation, the manufacturer of ... process equipment, has appointed Kirk Staller as Sales Engineering ... Staller holds a B.S. degree from Purdue University and ... place, much of it with a manufacturer of centrifugal ... office. , “We are pleased to have ...
Breaking Biology Technology:Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Quick Opens Office in France to Serve Life Science Community In France and Neighboring French-Speaking Countries 2Vaccinex announces publication of preclinical studies with an anti-SEMA4D antibody in animal models of neuroinflammatory and demyelinating disease 2Kirk Staller Joins Graphite Metallizing Corporation 2
... , No more siRNA design and testing , ... 1 day , , ... , Simplify Your Gene , ... use of small interfering RNAs (siRNAs) to induce targeted gene , ...
... Ambion scientists have engineered a mutant form of ... full-length cDNA. This engineered reverse transcriptase, , <A ... href="http://www.ambion.com/catalog/CatNum.php?2048">ArrayScript , (patent pending), ... than wild type RTs, and rivals even the newest engineered RTs on , ...
... offers a complete Gene Expression Profiling Service* for Affymetrix , ... Service offering, , no project is too ... consultation with Ambion's team of experienced array and informatics ... long history of providing innovative, , high ...
Cached Biology Technology:Avoid siRNA Design Altogether! 2Avoid siRNA Design Altogether! 3ArrayScript RT: Maximize Yields of Full-length cDNA 2ArrayScript RT: Maximize Yields of Full-length cDNA 3Ambion Offers Gene Expression Profiling Service 2Ambion Offers Gene Expression Profiling Service 3
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z71,448-8) or contact ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: