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Protein protects lung cancer cells from efforts to fix or kill them
Date:2/28/2008

GAINESVILLE, Fla. --- A protein that helps lung cancer cells thrive appears to do so by blocking healthy cells ability to fix themselves when radiation or chemicals such as nicotine damage their DNA, according to a University of Florida study to be published Friday (Feb. 29) in the journal Molecular Cell.

High levels of the protein, known as Bc12, are found in the cells of lung cancer patients who smoke.

Previous UF research has shown that nicotine activates the protein, which helps tumor cells live long past their natural lifespan and resist chemotherapy. The new findings explain how the protein enables cancer cells to circumvent the bodys own efforts to change them back into healthy cells -- or evade treatments designed to kill them.

Cancer is frequently associated with the accumulation of genetic aberrations in cells chromosomes. If these damaged cells cant access their built-in repair system and subsequently survive long enough to divide and multiply, they pass along their mutations.

If a cell experiences DNA damage, often that DNA can be repaired. But we found that Bc12 can block the DNA repair mechanism, which promotes tumor formation and genetic instability, said Dr. Xingming Deng, an assistant professor in UFs College of Medicine who is affiliated with the UF Shands Cancer Center. This is a very important fundamental mechanism that explains why this protein has (a cancer-forming) function.

Researchers say just one cell that develops a genetic mutation and is unable to repair itself could be enough for a full-blown tumor to develop.

Lung cancer is the No. 1 killer of all cancer types; it is the most dangerous, Deng said. We wanted to find a way to treat lung cancer, how to prevent lung cancer, because lung cancer prognosis is very poor.

Nearly 162,000 people will die from lung cancer in 2008, accounting for about 29 percent of all cancer deaths, according to the American Cancer Society. More
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Contact: Melanie Fridl Ross
ufcardiac@aol.com
352-690-7051
University of Florida
Source:Eurekalert

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