Navigation Links
Protein origami: Quick folders are the best
Date:1/31/2013

eins from the Protein Database (PDB) according to age. For this study, Minglei Wang in his laboratory identified protein sequences in the genomes, which had the same folding structure as the known proteins. He then applied an algorithm to compare them to each other on a time scale. In this way, it is possible to determine which proteins became part of which organism and when. After that, Cedric Debes, a member of Dr. Grter's group, applied a mathematical model to predict the folding rate of proteins. The individual folding steps differ in speed and can take from nanoseconds to minutes. No microscope or laser would be able to capture these different time scales for so many proteins. A computer simulation calculating all folding structures in all proteins would take centuries to run on a mainframe computer. This is why the researchers worked with a less data-intensive method. They calculated the folding speed of the single proteins using structures that have been previously determined in experiments: A protein always folds at the same points. If these points are far apart from each other, it takes longer to fold than if they lie close to each other. With the so-called Size-Modified Contact Order (SMCO), it is possible to predict how fast these points will meet and thus how fast the protein will fold, regardless of its length.

"Our results show that in the beginning there were proteins which could not fold very well," Dr. Grter summarizes. "Over time, nature improved protein folding so that eventually, more complex structures such as the many specialized proteins of humans were able to develop."

Shorter and faster for evolution

Amino acid chains, which make up proteins, also became shorter over the course of evolution. This was another factor contributing to the increase in folding speed, as has been shown in the study.

"Since eukaryotes, i.e. organisms with a cell nucleus, emerged, protein folding became somewhat less crucial," says Fr
'/>"/>

Contact: Peter Saueressig
peter.saueressig@hiits.org
49-622-153-3245
Heidelberg Institute for Theoretical Studies (HITS)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Pitt team finds Achilles Heel of key HIV replication protein
2. First special edition updating progress on efforts to map human proteins
3. Study: Odd biochemistry yields lethal bacterial protein
4. Protein structure: Immune system foiled by a hairpin
5. How the protein transport machinery in the chloroplasts of higher plants developed
6. Scientists discover structure of protein essential for quality control, nerve function
7. Protein production: Going viral
8. New study defines the long-sought structure of a protein necessary for cell-cell interaction
9. NYU biologists identify proteins vital to chromosome segregation
10. Removing protein garbage in nerve cells may help control 2 neurodegenerative diseases
11. Protein creates paths for growing nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein origami: Quick folders are the best
(Date:4/24/2014)... droplet of clear liquid can bend light, acting as ... have developed a new process to create inexpensive high ... apiece. , Because they,re so inexpensive, the lenses ... tools to detect diseases in the field, scientific research ... education in classrooms. , "What I,m really excited ...
(Date:4/23/2014)... to early fetal death according to a new study ... Hospital Los Angeles and Ulaanbaatar, Mongolia the coldest ... published today in the journal BMC Pregnancy and ... seasonal ambient air pollutants and pregnancy loss in Ulaanbaatar ... highest levels of air pollution of all world capitals, ...
(Date:4/23/2014)... release is available in French and ... Montreal, 23 April 2014Today, the CEC released its Conservation ... Collaborative Approach to Conservation, which identifies 29 priority conservation ... that includes 11 different protected areas in the states ... highly diverse arid and semi-arid habitats inhabited by rare ...
Breaking Biology News(10 mins):Bake your own droplet lens 2Bake your own droplet lens 3Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3
... Spanish . , Geraniums may hold the key ... 300 plant species and costs the ornamental plant industry $450 ... Agricultural Research Service (ARS). The beetle, Popillia ... plants, including ornamentals, soybean, maize, fruits and vegetables. But within ...
... book, "Strategic Bargaining and Cooperation in Greenhouse Gas Mitigations," ... work together to reduce carbon dioxide emissions. He also ... fuels whether they contribute to climate change or ... and I,m not making a scientific judgment here ...
... the expense of costly treatments for cancer and ... by growing these human therapeutic proteins in algaerapidly ... attention for their ability to produce biofuels. ... this week in Plant Biotechnology Journal, which sought ...
Cached Biology News:Geraniums could help control devastating Japanese beetle 2Cool model for a hot planet 2Cool model for a hot planet 3Study shows potential for using algae to produce human therapeutic proteins 2Study shows potential for using algae to produce human therapeutic proteins 3Study shows potential for using algae to produce human therapeutic proteins 4
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest ... research medicinal plants and therapeutic derivatives thereof has ... professionals, and researchers about the challenges of adulterated ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society for ...
(Date:1/14/2014)... January 14, 2014 Global Record ... innovative information technology solutions for patients, physicians, the ... stakeholders, announced today the signing of a three-year ... and Drug Administration (FDA). This initiative is ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... MOUNTAIN VIEW, Calif., Feb. 25 Alexza,Pharmaceuticals, ... that it has initiated,its first Phase 3 ... an inhalation product candidate being developed for ... schizophrenia or bipolar disorder. Alexza,believes the novel, ...
... data by Dr. J.,Barthelow Classen shows that vaccines ... a strong family history of insulin dependent,diabetes. Previous ... recipients at a rate which exceeds their benefit ... particularly toxic to those,with a strong family history ...
... falling on only 9 percent of Californias Mojave ... electricity needs if the energy could be efficiently ... cell technologies are too expensive and inefficient for ... University researchers has developed a new anode coating ...
Cached Biology Technology:Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 2Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 3Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 4Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 5Special coating greatly improves solar cell performance 2
Mouse monoclonal [2G1] to Vancomycin ( Abpromise for all tested applications)....
Rab1A...
... to LYZL6 ( Abpromise for ... Antigen: Synthetic peptide: DWLCL AFVE ... corresponding to amino acids 46-100 of ... Gene ID: 57151 ...
Request Info...
Biology Products: