Navigation Links
Protein marker for schizophrenia risk
Date:7/8/2008

A protein found in immune cells may be a reliable marker for schizophrenia risk, report researchers in a new proteomics study appearing in the July issue of Molecular and Cellular proteomics.

Schizophrenia is a severe and complex psychiatric illness that affects about 1% of the population. Diagnosis currently relies on subjective clinical interviews and the assessment of ambiguous symptoms, which frequently leads to delayed diagnosis and treatment. As such, biomarkers that would indicate schizophrenia risk or onset would be extremely useful.

Sabine Bahn and colleagues sought to find such a "protein fingerprint" in the blood (due to its accessibility). They compared protein profiles of schizophrenia patients and controls using mass spectrometry and identified two peaks highlighting a significant change. These were identified as alpha defensins, proteins responsible for killing microbes and viruses in the innate immune response.

Bahn and colleagues confirmed their findings by examining alpha defensin levels in the blood of 21 twin pairs discordant for schizophrenia (where one sibling manifests the disease while the other does not). In these twin sets, both siblings had significantly elevated alpha defensins as compared with a group of control twins. Changes were also found in patients who were investigated soon after diagnosis, which means that higher levels of alpha defensins were not caused by medication or progression of the disease.

Because both discordant twins had elevated alpha defensins, these proteins do not indicate disease onset, but the researchers suggest they could be a useful and simple marker for evaluating schizophrenia risk. Although they believe that more markers will be needed in order to develop a sensitive and specific schizophrenia blood test.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists reveal the key mechanisms for affinity between transient binding proteins
2. Small protein may have big role in making more bone and less fat
3. A mammalian clock protein responds directly to light
4. Scientists find potential protein biomarkers for growth hormone
5. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
6. Researchers reveal insights into hidden world of protein folding
7. Mechanism explains link between apolipoprotein E and Alzheimers disease
8. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
9. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
10. Protein fibrils as alternative plastics?
11. Montana State University researchers map iron transport protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)...  GCE Solutions, a global clinical research organization (CRO), announces the ... on October 4, 2017. Shadow is designed to assist medical writers ... 0070 of the European Medicines Agency (EMA) in meeting the requirements ... ... ...
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
(Date:10/9/2017)... Jupiter, FL (PRWEB) , ... October 09, 2017 , ... ... episode, scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on ... Agriculture industry is faced with the challenge of how to continue to feed a ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the ... in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective ...
(Date:10/7/2017)... 2017  The 2017 Nobel Prize in Chemistry ... Dubochet, Joachim Frank and Richard ... microscopy (cryo-EM) have helped to broaden the ... community. The winners worked with systems manufactured by ... highly resolved, three-dimensional images of protein structures that ...
Breaking Biology Technology: