Navigation Links
Protein marker for schizophrenia risk
Date:7/8/2008

A protein found in immune cells may be a reliable marker for schizophrenia risk, report researchers in a new proteomics study appearing in the July issue of Molecular and Cellular proteomics.

Schizophrenia is a severe and complex psychiatric illness that affects about 1% of the population. Diagnosis currently relies on subjective clinical interviews and the assessment of ambiguous symptoms, which frequently leads to delayed diagnosis and treatment. As such, biomarkers that would indicate schizophrenia risk or onset would be extremely useful.

Sabine Bahn and colleagues sought to find such a "protein fingerprint" in the blood (due to its accessibility). They compared protein profiles of schizophrenia patients and controls using mass spectrometry and identified two peaks highlighting a significant change. These were identified as alpha defensins, proteins responsible for killing microbes and viruses in the innate immune response.

Bahn and colleagues confirmed their findings by examining alpha defensin levels in the blood of 21 twin pairs discordant for schizophrenia (where one sibling manifests the disease while the other does not). In these twin sets, both siblings had significantly elevated alpha defensins as compared with a group of control twins. Changes were also found in patients who were investigated soon after diagnosis, which means that higher levels of alpha defensins were not caused by medication or progression of the disease.

Because both discordant twins had elevated alpha defensins, these proteins do not indicate disease onset, but the researchers suggest they could be a useful and simple marker for evaluating schizophrenia risk. Although they believe that more markers will be needed in order to develop a sensitive and specific schizophrenia blood test.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists reveal the key mechanisms for affinity between transient binding proteins
2. Small protein may have big role in making more bone and less fat
3. A mammalian clock protein responds directly to light
4. Scientists find potential protein biomarkers for growth hormone
5. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
6. Researchers reveal insights into hidden world of protein folding
7. Mechanism explains link between apolipoprotein E and Alzheimers disease
8. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
9. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
10. Protein fibrils as alternative plastics?
11. Montana State University researchers map iron transport protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:5/24/2016)... -- Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the ... latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Display- Ampronix News ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
Breaking Biology Technology: