Navigation Links
Protein love triangle key to crowning bees queens?
Date:11/9/2011

A honey bee becomes a royal queen or a common worker as a result of the food she receives as a larva. While it has been well established that royal jelly is the diet that makes bees queens, the molecular path from food to queen is still in dispute. However, scientists at Arizona State University, led by Adam Dolezal and Gro Amdam, have helped reconcile some of the conflicts about bee development and the role of insulin pathways and partner proteins. Their article "IIS and TOR nutrient-signaling pathways act via juvenile hormone to influence honey bee cast fate" has been published in the December issue of the Journal of Experimental Biology.

Central to the dispute within the scientific community about "who would be queen" has been a ground-breaking study published in the journal Nature by Japanese scientist Masaki Kamakura in 2011. He found that a single protein in royal jelly, called royalactin, activated queen development in larval bees through interaction with an epidermal growth factor receptor (EGFR). Kamakura's work suggested that insulin signals do not play a role in queen development, despite previous studies suggesting otherwise, including work pioneered with the insulin receptor protein by Amdam's group.

Undeterred by Kamakura's findings, Dolezal, a doctoral student, and Amdam, a Pew Biomedical Scholar and professor in ASU's School of Life Sciences, looked for ways to resolve the disparity between the research studies. Amdam's team's first step involved taking control of the insulin receptor's partner protein, IRS, which the insulin receptor relies upon for signaling. The scientists found that by blocking IRS, they caused a central developmental hormone to crash, which forced larval bees into the worker mold despite their diet of royal jelly. Amdam's team then "rescued" the now worker-destined bees. They found that by giving the bees hormone treatments, the bees could then develop along the queen trajectory.

However, while Dolezal and Amdam's studies showed that they could block queen development, and then rescue it, and clarified the role of IRS in the queen-making process, their work could not resolve the remaining conflict with Kamakura's results.

Taking a new tack, the Amdam group, which also included Navdeep Mutti, Florian Wolschin, and Jasdeep Mutti, and Washington State University scientist Kulvinder Gill, turned to mathematical modeling, combining their results with approaches that analyze potential partner interactions. These models, developed to understand and clarify complex relationships in physics and biology, allowed the ASU researchers to build a model of consensus explaining how the IRS partner protein could partner to both epidermal growth factor receptor and the insulin receptor. And while the insulin receptor itself may play no role as Kamakura's findings suggest Dolezal and Amdam's findings show that the IRS partner protein may in fact be key to a molecular love triangle, interacting with both receptors, and with the bond to epidermal growth factor receptor being the crowning feature in queen development.


'/>"/>

Contact: Margaret Coulombe
margaret.coulombe@asu.edu
480-727-8934
Arizona State University
Source:Eurekalert  

Related biology news :

1. New study uncovers how brain cells degrade dangerous protein aggregates
2. Molecule serves as a key in some protein interactions
3. Rutgers neuroscientist says protein could prevent secondary damage after stroke
4. The tangled web in Alzheimers protein deposits is more complex than once thought
5. Protein microarrays may reveal new weapons against malaria
6. So many proteins, so much promise
7. Gladstone scientists identify protein form linked to Huntingtons disease
8. Researchers build largest protein interaction map to date
9. Gene regulatory protein is reduced in bipolar disorder
10. Bioengineered protein shows preliminary promise as new therapy for hemophilia
11. X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein love triangle key to crowning bees queens?
(Date:4/5/2017)... NEW YORK , April 5, 2017 ... security, is announcing that the server component of the ... is known for providing the end-to-end security architecture that ... customers. HYPR has already secured over 15 ... system makers including manufacturers of connected home product suites ...
(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University (PolyU) ... ground breaking 3D fingerprint minutiae recovery and matching technology, pushing contactless ... use in identification, crime investigation, immigration control, security of access and ... ... A research team led by Dr Ajay Kumar ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give ... Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles ...
(Date:10/10/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... October 10, ... ... risk management, technological innovation and business process optimization firm for the life sciences ... the BoxWorks conference in San Francisco. , The presentation, “Automating GxP ...
Breaking Biology Technology: