Navigation Links
Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
Date:6/1/2009

eiving, or post-synaptic side of the gap, when the function of the oligophrenin protein was disturbed under carefully controlled conditions. Using samples taken from the rat hippocampus -- a well-studied brain region known to be important in learning and memory -- the team confirmed that the signaling protein is not essential for the formation of dendritic spines, but that it is needed for the proper maintenance of their structure. Importantly, in this maintenance function, the OPHN1 protein was found to play a key role in both the maturation of excitatory synapses and in their plasticity, or ability to vary in strength.

Two things are particularly intriguing about the team's results, reported in the June 1 issue of the journal Genes & Development.. They have been able to show, for the first time, how OPHN1 performs these roles at excitatory synapses. They have also made important progress in elucidating the pathophysiology of mutations in the OPHN1 gene.

The protein normally encoded by the OPHN1 gene belongs to what scientists call the Rho subfamily of GTP-binding proteins. "Members of this family are known to be key regulators of the actin cytoskeleton and affect many aspects of neuronal development," Van Aelst notes. The actin cytoskeleton is the gossamer, filament-like scaffolding that provides structure for the contents of cells. "All mutations that we know of in the OPHN1 gene lead to OPHN1 proteins that do not function," Van Aelst says. "This naturally raised the question of what the protein's normal function is at excitatory synapses, and what goes wrong when the gene that encodes it develops a mutation."

By manipulating OPHN1 gene expression on the postsynaptic side of the gap, the team was able to unravel a key link between OPHN1 function and synaptic activity. They showed that neuronal activity, which triggers the activation of post-synaptic cellular receptors, called NMDA receptors, is needed for the function of O
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
(Date:4/2/2015)... -- Fingerprint Cards (FPC) has received an ... distributor World Peace Industrial Group (WPI), part of WPG ... major part of the shipments will take place during ... manufacturers in China . The order ... revenue guidance of + 1 000 MSEK for 2015.  ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... of field work by associate professor James Davis Reimer and ... in Okinawa, Japan has found two new species of ... The species belong to the genus Neozoanthus , which ... Indian Ocean. Surprisingly, the new species were found in the ...
... of the journal Environmental Health Perspectives and ... Environment" a companion report by the Dartmouth-led Coastal and ... mercury released into the air and then deposited into ... U.S. and globally. Over the past century, ...
... 2012 Academic, Industry Professionals can use ... Ocean Thin Films is calling for grant proposals featuring ... SpectroCam is an imaging system that integrates scientific-grade sensors ... gives participants the unique opportunity to add a high-end ...
Cached Biology News:An ocean away: 2 new encrusting anemones found in unexpected locations 2Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings 2Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings 3Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings 4Ocean Thin Films Announces Multispectral Imaging Research Grant Program 2Ocean Thin Films Announces Multispectral Imaging Research Grant Program 3
(Date:5/4/2015)... AVIV, Israel , May 4, 2015  Tikcro ... filed its annual report on Form 20-F for the ... Securities and Exchange Commission ("SEC"). The annual report on ... the development of antibodies in the area of cancer ... with superior qualities of high specificity and binding in ...
(Date:5/4/2015)... 4, 2015 /PRNewswire/ - The Fight Against Cancer ... to announce the formation of Turnstone Biologics Inc. ... for cancer that harness the patient,s own immune ... collaboration between the Children,s Hospital of ... University, the Ontario Institute for Cancer Research (OICR), ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Achieved primarily ... produces slides that boast 10 to 100x better detail ... the capabilities of all existing light microscopy methods, it ... micrographs were chosen as the frame of reference because ... , The goal from the earliest discovery days ...
(Date:5/4/2015)... , May 4, 2015 ... thousands of med students prepare for the United States ... world-leading provider of scientific, technical and medical information products ... free MOOC (Massive Open Online Course) designed to help ... Examination (USMLE) Step 1, the first and most daunting ...
Breaking Biology Technology:Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3
... Therapeutics, Inc. today presented final results from its Phase ... of exenatide) for the treatment of type 2 diabetes ... the Study of Diabetes in Vienna, Austria. Results of ... (FPG) within 24 hours of the start of treatment ...
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) today announced ... a conference call and webcast on Wednesday, October 28, at ... , , U.S. / Canada Dial-in Number: ... Participant Code: 51404008, Replay ...
... 30 InteKrin Therapeutics Inc. announced today positive results for ... 45th European Association for the Study of Diabetes ... will be presented at 1:45 PM Friday, October 2, 2009 ... His presentation is entitled "Impact of INT131 Besylate, a Selective ...
Cached Biology Technology:Intarcia Therapeutics, Inc. Presents Positive Results of ITCA 650 Phase 1b Study in Type 2 Diabetes at the European Association for the Study of Diabetes Conference 2Intarcia Therapeutics, Inc. Presents Positive Results of ITCA 650 Phase 1b Study in Type 2 Diabetes at the European Association for the Study of Diabetes Conference 3Intarcia Therapeutics, Inc. Presents Positive Results of ITCA 650 Phase 1b Study in Type 2 Diabetes at the European Association for the Study of Diabetes Conference 4Intarcia Therapeutics, Inc. Presents Positive Results of ITCA 650 Phase 1b Study in Type 2 Diabetes at the European Association for the Study of Diabetes Conference 5BioMarin to Host Third Quarter 2009 Financial Results Conference Call and Webcast on Wednesday, October 28 at 5:00 p.m. ET 2InteKrin Therapeutics Presents Positive INT131 Phase 2b Results at the 45th Annual European Association for the Study of Diabetes Meeting 2
...
Full-length cDNA 5-PRIME end of clone CS0DE013YM09 of Placenta of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86TS7] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
... deuterium atoms at the 9, 10, 12, and ... an internal standard for the quantification of 9(S)-HODE ... by the lipoxygenation of linoleic acid in both ... atherosclerotic plaques, as an esterified component of membrane ...
Biology Products: