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Protein linked to change in tissue that surround and support breast tumors
Date:6/12/2009

s," says the study's other senior author, Anna Riegel, PhD, a professor of oncology and associate director for cancer research education at Lombardi.

In this study, the researchers used transgenic mice in which either the AIB1 or the AIB1delta3 slice variant gene were over-expressed. Upon examination of mammary tissue, they found that the tissue in mice with the splice variant of AIB1 was thicker than that seen in mice with too much of the parent protein. This fibrosis may be related to the hard, scar-like tissue frequently seen around a breast tumor, Furth says. "What we don't know is whether generation of this dense tissue, which seems to increase growth factor responses, is required for cancer to develop, or whether cancer would regress if development of this abnormal stroma was interrupted," she says.


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Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2

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