Navigation Links
Protein linked to change in tissue that surround and support breast tumors
Date:6/12/2009

Washington, DC A protein known to be overly active in breast cancer can exist in a form that seems to change the structural composition of mammary tissue, potentially making it more conducive to tumor progression, say researchers from the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC).

At the annual meeting of the Endocrine Society in Washington, DC, the scientists report that the protein, AIB1 (Amplified in Breast Cancer 1), has a shorter form known as AIB1delta3 which turns breast tissue more fibrous. The researchers say this shorter form may contribute to the dense breast tissue that is a known risk factor for breast cancer.

"We found that AIB1delta3 alters the stroma, or environment that surrounds and supports cancer cells, producing excessive fibrosis," says the study's lead author, Priscilla Furth, MD, Professor of Oncology and Medicine. "This is significant, because disordered interactions between the epithelial and stromal compartments are being increasingly recognized as an important component of breast cancer risk."

A splice variant occurs as the gene is expressed, resulting in deletion of extra amino acids when the protein is formed, changing its shape and possibly its function. Many genes produce these kinds of variants, and the GUMC researchers wanted to know if AIB1delta3 played the same role, or a different one, than its parent larger protein, AIB1, which is known to be over-produced at the RNA level in a significant portion of breast cancers.

Previous research at GUMC has found that AIB1 acts as a co-activator of growth proteins, such as estrogen receptor alpha and HER2/neu, which are also often over-expressed in tumor development. "AIB1 and its more active variant potentiate both estrogen and HER2/Neu at different stages of breast cancer. We knew that AIB1 delta 3 was more active than AIB1 but this study is evidence that we have of a major functional difference between the two proteins," says the study's other senior author, Anna Riegel, PhD, a professor of oncology and associate director for cancer research education at Lombardi.

In this study, the researchers used transgenic mice in which either the AIB1 or the AIB1delta3 slice variant gene were over-expressed. Upon examination of mammary tissue, they found that the tissue in mice with the splice variant of AIB1 was thicker than that seen in mice with too much of the parent protein. This fibrosis may be related to the hard, scar-like tissue frequently seen around a breast tumor, Furth says. "What we don't know is whether generation of this dense tissue, which seems to increase growth factor responses, is required for cancer to develop, or whether cancer would regress if development of this abnormal stroma was interrupted," she says.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... ... Zalewsky in offering LANAP® and LAPIP™ laser treatments. Drs. Hoge and Zalewsky are ... patients, a minimally invasive and less painful option that produces real results. , ...
(Date:9/21/2017)... ... September 21, 2017 , ... Dr. Greg Leyer, Chief Scientific ... on September 27th. His presentation is at 12:10pm in the Probiotics Resource Center, Mandalay ... at SupplySide West and discuss how probiotics have shown impressive data in areas outside ...
(Date:9/21/2017)... ... September 21, 2017 , ... Today, ... professionals, has announced the addition of 5 new courses to its prospectus. These ... with Regulation 21 CFR Part 11 on Electronic Records and Electronic Signatures (Part ...
(Date:9/20/2017)... ... September 20, 2017 , ... The award-winning producers behind the ... feature new innovations aimed at helping farmers solve the problem of nitrogen loss. ... Tuesdays at 8:30aET on RFD-TV. Check your local listings for more info. ...
Breaking Biology Technology: