Navigation Links
Protein key to cell motility has implications for stopping cancer metastasis
Date:3/12/2014

PHILADELPHIA - "Cell movement is the basic recipe of life, and all cells have the capacity to move," says Roberto Dominguez, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania. Motility albeit on a cellular spatial scale -- is necessary for wound healing, clotting, fetal development, nerve connections, and the immune response, among other functions. On the other hand, cell movement can be deleterious when cancer cells break away from tumors and migrate to set up shop in other tissues during cancer metastasis.

The Dominguez team, with postdoctoral fellow David Kast, PhD, and colleagues, report online ahead of print in Nature Structural & Molecular Biology how a key cell-movement protein called IRSp53 is regulated in a resting and active state, and what this means for cancer-cell metastasis.

"We characterized how IRSp53 connects to the cell-motility machinery," says Kast. "It does this by starting the formation of cell filopodia - extensions that form when a cell needs to move."

"Cells move like an inchworm," explains Dominguez. "Filopodia are at the leading edge of moving cells." The trailing end of the cell follows the move forward through contraction of actin and myosin in the cytoskeleton, much like muscle contraction. A cell pushes out the leading edge of its membrane, and sticks it down on whatever it is moving across, namely other cells, and then moves the cell body along, unsticking the back end. This sets the cell up for its next move.

IRSp53 contains a region called a BAR domain that binds to and shapes cell membranes. Other parts of the protein connect it to the cytoskeleton (internal bits that give a cell structure and shape). Together, through the binding of cell membranes and other proteins IRSp53 regulates cell movement. The team found that in the resting state, human IRSp53 adopts a closed shape that prevents it from interacting with the membrane and the cytoskele
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Fruit flies help uncover tumor-preventing protein complex
2. Diets high in animal protein may help prevent functional decline in elderly individuals
3. Phosphorylation of tau protein in rats subjected to cerebral ischemia-reperfusion injury
4. New probes from Scripps research quantify folded and misfolded protein levels in cells
5. Characterization of stink bug saliva proteins opens door to controlling pests
6. A key protein is discovered as essential for malaria parasite transmission to mosquitos
7. A*STAR scientists discover proteins role in human memory and learning functions
8. Mitosis mystery solved as role of key protein is confirmed
9. Superbright and fast X-rays image single layer of proteins
10. New insight into protein misfolding in neurodegenerative disorders
11. A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein key to cell motility has implications for stopping cancer metastasis
(Date:7/30/2014)... roughly 3,000 pieces is still in its infant stage. ... be of major significance. "Amazingly often, we are findingin ... amber that we found in Baltic amber," explained Bonn ... amber comes from the Baltic Sea region, which is ... are, e.g., the coastal regions of Mecklenburg, Poland and ...
(Date:7/30/2014)... scientists unveiled the first high-resolution map of the ... country of Per. The new and improved methodology ... change for future market-based carbon economies. The ... ecological diversity and it provides the critical input ... conservation, land use, and enforcement purposes. The technique ...
(Date:7/29/2014)... Bristol,s Nutrition and Behaviour Unit (NBU) has looked into ... meals. , The research, to be presented at the ... 2014) in Seattle, USA this week [29 July to ... was led by Professor Jeff Brunstrom, and is based ... of a Biotechnology and Biological Sciences Research Council (BBSRC) ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3
... OCT. 31, 2011 A highly renowned obstetrician, professor ... and diabetic women have a higher risk of becoming ... later in life, received the March of Dimes 2011 ... of maternal-fetal nutrition. , Patrick M. Catalano, ...
... has been mapped. Now, it,s on to proteins, a much ... millions of distinct protein molecules in our bodies. Many of ... A team led by Northwestern University chemical biologist Neil Kelleher ... identify thousands of protein molecules quickly. Many have been skeptical ...
... at Weill Cornell Medical College say they have taken an ... regeneration -- an advance that could effectively treat millions of ... issue of the journal Cell , the research team ... that trigger generation of new lung alveoli, the numerous, tiny, ...
Cached Biology News:March of Dimes honors researcher who linked maternal obesity to a baby's long-term health 2So many proteins, so much promise 2So many proteins, so much promise 3Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers 2Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers 3Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers 4
(Date:7/30/2014)... (PRWEB) July 30, 2014 Selexis ... for biologic drug discovery and mammalian cell line development, ... CHO-Mplus Libraries ™ will be presented at the 10th ... being held, September 8 – 10, 2014 at the ... , The following abstract will be presented during ...
(Date:7/30/2014)... 30, 2014 With the accelerated ... personal health expenditure as well as the improved ... China diagnostic reagent industry has been developing quickly, ... In 2013, Chinese in vitro diagnostics market size ... from in vitro diagnostic reagents. , Read ...
(Date:7/30/2014)... 30, 2014 Vycom announces the addition ... designed to meet Factory Mutual (FM) 4910 fire propagation ... as wet benches, process tools, fume hoods, furniture and ... damage to semiconductor wafers used in electronic chip manufacturing. ... PVC solution with excellent workability and superior aesthetics. It ...
(Date:7/30/2014)... , July 30, 2014  Dyadic International, Inc. ... whose patented and proprietary technologies are used to ... proteins for the bioenergy, bio-based chemical, biopharmaceutical and ... Thomas "Tom" Dubinski as Vice President and Chief ... the financial and information technology operations for Dyadic ...
Breaking Biology Technology:Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 2Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 3China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4
... markets, the trend in health care employment could be counted on ... bringing yearly growth up over 345,000.The MedZilla.com Employment Report analyzes the ... ... Seattle, WA (Vocus) December 3, 2008 -- The U.S. economy ...
... and HOUSTON, Dec. 2 Transgenomic,Inc. (OTC ... Inc. (OTC,Bulletin Board: PWRM) today announced that ... acquire exclusive rights for Power3 Medical,s Neurodegenerative,Biomarkers, ... Alzheimer,s,and Parkinson,s disease. Transgenomic plans to ...
... postmenopause , , MONTVALE, N.J., ... symptoms is a challenge for women experiencing menopause. OBG ... have recently published a supplement titled Vasomotor symptoms: Managing ... James McGregor, MD, CM and Lee P. Shulman, MD, discuss ...
Cached Biology Technology:The MedZilla Report: October 2008 Employment Outlook for Biotech/Pharma/Health 2The MedZilla Report: October 2008 Employment Outlook for Biotech/Pharma/Health 3Transgenomic Signs Letter of Intent for an Agreement to Exclusive License With Option to Acquire Power3 Medical Products' Neurodegenerative Diagnostics 2Transgenomic Signs Letter of Intent for an Agreement to Exclusive License With Option to Acquire Power3 Medical Products' Neurodegenerative Diagnostics 3Transgenomic Signs Letter of Intent for an Agreement to Exclusive License With Option to Acquire Power3 Medical Products' Neurodegenerative Diagnostics 4
...
Antibodies were affinity purified using epitopes specific to QKI immobilized on solid support....
Acrylamide, 500 g. Assay: > 99.9%, acrylic acid: < 0.001%. Conductivity (35%): < 2 umhos/cm.Risks: 45, 46, 48, 23, 24, 25 ; Safety Precautions: 53, 44. Category: Nucleotides & Enzymes & Biochemicals...
Assay Diluent Trial Pack, 4 x 100 mL...
Biology Products: