Navigation Links
Protein is potential new treatment target for adult pulmonary hypertension
Date:10/17/2011

AUGUSTA, Ga. A protein critical to development appears to have a grave impact on lungs exposed to smoking and air pollution, researchers report.

Blocking that protein, called calpain, in the lungs may prove an effective way to avoid narrow, scarred blood vessels and pulmonary hypertension, said Dr. Yunchao Su, pharmacologist at Georgia Health Sciences University.

"Calpain enables the bad behavior that occurs in pulmonary hypertension," said Su, corresponding author of the study published in the Journal of Clinical Investigation.

Pulmonary hypertension is an often progressive and deadly condition in which tiny blood vessels that permeate the lungs narrow, raising blood pressure and eventually enlarging the pumping chamber of the heart as it struggles to get blood inside the lungs.

Babies with heart defects can have it, but in adults it can result from chronic obstructive lung disease, or COPD, primarily caused by smoking (emphysema is the most common form of COPD) or air pollutants, including second-hand smoke. Inflamed and poorly oxygenated lungs start producing growth factors and other measures to constrict blood vessels in an effort to restore balance between blood flow and oxygen levels. This works in the short term, Su said, but a chronic stimulus such as smoking can make, ongoing constriction debilitating or deadly. Treatment improves symptoms such as shortness of breath, but the only cure is a heart-lung transplant.

Researchers found calpain gets activated by growth factors released by stressed lung tissue then multiplies the vascular remodeling by cleaving TGFbeta, another growth factor typically inactive in the lungs. Cleaving TGFbeta releases a strong, active form that increases cell proliferation and collagen production. A similar process helps heal a cut on the hand, but inside the blood vessel it's counterproductive, Su said.

Additionally, in animal models of pulmonary hypertension as wel
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein is potential new treatment target for adult pulmonary hypertension
(Date:3/12/2015)... WINSTON-SALEM, N.C. , March 12, 2015 ... afternoon at Brenner Children,s Hospital, part of Wake Forest ... an outreach initiative for the 2015 ACC Men,s Basketball ... taking pictures with them and getting their autographs. ... Wake Forest Baptist. It is the only children,s hospital ...
(Date:3/11/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) has ... by Product, Application & By Geography - Global Forecast ... , This report predicts that the access ... 2020, with an estimated CAGR of 10.6%. ... such as contact cards & readers, contactless cards & ...
(Date:3/10/2015)... Colo. , March 10, 2015 ... Flight "Personalized Medicine in Human Space ... and Thomas J. Goodwin , Ph.D. was recently ... of the past two years. Specifically, "Personalized ... most downloaded scientific papers published in 2013 and 2014 ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2
... when cooks in France and elsewhere will be slipping bits ... for a luxurious flavor, scientists are revealing the secrets that ... Their study, which could lead to better ways to determine ... ACS, Journal of Proteome Research . Mark ...
... The astonishing success of the alien invasive harlequin ladybird in ... to investigate a key ecological theory the Enemy Release ... new alien species arrives into a country or region it ... Writing in the latest issue of the ...
... of how cancer cells evolve could help scientists design ... , Researchers at Fred Hutchinson Cancer Research Center studying ... than resulting from a steady accumulation of small genetic ... to undergo large, drastic mutations. This insight could help ...
Cached Biology News:Scientists unearth secrets of Périgord truffles, the culinary 'black diamond' 2Harlequin ladybirds escape enemies while native species succumb 2New insights into cancer evolution help define screening window of opportunity 2New insights into cancer evolution help define screening window of opportunity 3
(Date:3/25/2015)... 25, 2015 Laboratory workers can ... and Analytical Balances to get best-performing features while ... weighing balances from the trusted brand include: , ... increase your efficiency by providing a large weighing ... Weighing modes include parts counting, percent weighing, checkweighing, ...
(Date:3/25/2015)... CAMBRIDGE, Mass. and REYKJAVIK, Iceland ... provides comprehensive capabilities for using the genome to create better ... publication of the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around ... authored by a team of deCODE scientists led by ...
(Date:3/25/2015)... 2015  Point-of-Care Partners, a leading health information ... launched the ePrescribing State Law Capsule -- a ... regulatory requirements in all 50 states and DC.  ... to change rapidly, so we have evolved our ... ultimately patients, need," said Tony Schueth , ...
(Date:3/25/2015)... Having added two International locations in ... 2014, ITRA Global proudly announced recently the organization’s expansion ... Alliance, based in the United States, is one of ... of commercial real estate. , Saltwood International ... that exclusively advises occupiers of office space, ensuring that ...
Breaking Biology Technology:New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Point-of-Care Partners Launches the ePrescribing State Law Capsule 2International Organization Expands its Global Reach to Warsaw, Poland 2
... group of Master of Science in Biotechnology students ... University of Wisconsin-Madison this weekend. For the past two years ... from last year's pilot class of 10, to get deeper ... ,"There is an interdependence in the program: business, science and ...
... to use a $75,000 grant to make the financial relationships ... available online. , ,The grant came from the Joyce ... policy. , ,All the information is already available, but ... is charged with keeping track of the financial relationships of ...
... been written, said, and even adjudicated about peer-to-peer music sharing ... service promising to legitimize song sharing. Yet Mercora ... million people who have downloaded the software since its quiet ... IM Radio the IM stands for Individual Modulation ...
Cached Biology Technology:New UW master's program ramps up to fill demand for biotech skills 2New UW master's program ramps up to fill demand for biotech skills 3Ethics Board to put financial disclosures online with new grant 2Mercora gets music sharing right 2Mercora gets music sharing right 3
...
...
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
... The Universal Vacuum System UVS400 is ... system. The UVS400 combines a refrigerated vapor ... in a single integrated unit. The easy-to-use, ... recovered solvent into single jar for easy ...
Biology Products: