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Protein interplay in muscle tied to life span
Date:11/14/2013

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Bai acknowledged that the team doesn't yet know why degraded muscle performance due to a lack of autophagy should result in reduced life span. One possibility could be that aging flies simply lose the mobility needed to compete for food. But the group has embarked on a new study of the most important muscle tissue: the heart. They are conducting experiments to examine whether the chain of events preventing autophagy affects the fruit flies' heart pumping. In 2004 Tatar and his collaborator Rolf Bodmer connected insulin and dFOXO to fly heart performance.

Eager to see how this extends to people, the team is also looking at activin signaling and autophagy in mammalian cell cultures, Bai said.

"That's potentially translational toward human biology," Bai said. "If we have evidence from mammals, it could be useful for future therapeutic targets and drug design."


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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

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