Navigation Links
Protein interplay in muscle tied to life span
Date:11/14/2013

PROVIDENCE, R.I. [Brown University] Fruit flies are notoriously short-lived but scientists interested in the biology of aging in all animals have begun to understand why some fruit flies live longer than others. They have documented a direct association between insulin and life span, for example, and have observed a tradeoff between prolific reproduction and longevity. A new study, which may have broad implications across species, ties those findings more closely together by tracing an insulin signaling cascade through to protein quality control in muscle tissue and shortened life span.

The central feature of the study published in the November 2013 issue of PLoS Genetics is the newly discovered role of the fruit fly equivalent of the mammalian protein complex activin. They found that it blocks the natural mechanism in muscle cells for cleaning out misfolded proteins, leading to a decline in muscle performance. In what scientists at Brown University think is no coincidence, blocking the activity of that activin equivalent, called dawdle, can lengthen a fly's life span by as much as 20 percent, about 10 days.

What excites the researchers is not that they can allow flies to stick around another week or two, but that the same fundamental proteins they have implicated in flies are "conserved" in evolution, meaning they also operate in mammals including humans.

"The ultimate goal of our research is to understand how certain molecular signaling pathways control aging across all species in general," said study lead author Hua Bai, a postdoctoral researcher in the ecology and evolutionary biology lab of Marc Tatar, professor of biology at Brown. "For now this research is in fruit flies, but we think it can be extended to human aging biology. This signaling is quite conserved evolutionarily."

From insulin to muscle

Bai, Tatar, and their co-authors began the study armed with the understanding that a reductio
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Protein-rich breakfast helps to curb appetite throughout the morning, scientists find
2. Frontiers in Agricultural Sustainability: Studying the Protein Supply Chain
3. USC study reveals a protein that keeps people -- and their skeletons -- organized
4. Structure of bacterial nanowire protein hints at secrets of conduction
5. New look identifies crucial clumping of diabetes-causing proteins
6. Protein illustrates muscle damage: McMaster researchers
7. Biochemists find incomplete protein digestion is a useful thing for some bacteria
8. Newly identified proteins make promising targets for blocking graft-vs.-host disease
9. A high protein diet and meal replacements can reduce rebound weight gain
10. Absence of the SMG1 protein could contribute to Parkinsons and other neurological disorders
11. How problems with an Alzheimers protein can jam up traffic in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein interplay in muscle tied to life span
(Date:8/27/2014)... /PRNewswire-iReach/ -- The IEEE Engineering in Medicine and Biology ... International Conference (EMBC,14), this year being held at the ... Illinois , from Tuesday, August 26 through Saturday, ... industry professionals in science, medicine, and engineering are registered ... This year,s conference theme is ...
(Date:8/27/2014)... as giant, frightening beasts. But every creature is a ... slab containing fossils of 24 very young dinosaurs and ... hatchlings overseen by a caretaker, according to a new ... P. Hedrick and Peter Dodson led the work, collaborating ... where the specimen is held. Hedrick is a doctoral ...
(Date:8/27/2014)... is available in German . ... the most common inherited disease affecting the peripheral nervous ... Max Planck Institute of Experimental Medicine and University Medical ... cells is impaired in rats with the disease. These ... known as myelin, which facilitates the rapid transfer of ...
Breaking Biology News(10 mins):Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3Potential therapy for incurable Charcot-Marie-Tooth disease 2
... the first human clinical trial of a recombinant vaccine ... ?and the results indicate the vaccine is safe and ... Center researchers report. , The nearly year-long pilot study ... each group received a series of three injections of ...
... Medical Center have uncovered part of the genetic mechanism that ... , A team led by SFVAMC vascular surgeon Rajabrata Sarkar, ... is essential for the growth of new arteries when the ... identified and described, for the first time, the specific DNA ...
... Brookhaven National Laboratory have just launched a web-based 3-D ... a popular laboratory mouse (see http://www.bnl.gov/CTN/mouse/ ). ... extremely accurate anatomical templates and use them to map ... brain are metabolically active and where particular genes are ...
Cached Biology News:Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned 2Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned 3Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned 4Genetic key to growth of new arteries is identified 2Genetic key to growth of new arteries is identified 3
(Date:8/26/2014)... what they believe is the thinnest-possible semiconductor, a ... only three atoms thick. , The University of ... single-layer semiconductor materials can be connected in an ... result could be the basis for next-generation flexible ... and solar technologies. , "Heterojunctions are fundamental elements ...
(Date:8/26/2014)... , Aug. 26, 2014 An analysis by ... of all Mers CoV virus strains has ... back to 2012.  This conservation and sharing of specific ... Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did for the ... both of which have been found to be effective ...
(Date:8/26/2014)... added to the growing case for graphene being ... thing in the high-tech world by the two-dimensional ... of researchers led by a scientist with the ... Laboratory (Berkeley Lab) has reported the first experimental ... materials. The recorded charge transfer time clocked in ...
(Date:8/26/2014)... Ga. , Aug. 26, 2014  ViveBio, ... biological sample collection, stabilization and transportation, announced today ... Laboratory Procurement Services, LLC (LPS) of ... of products in the United States ... new class of ambient temperature dried biological specimen ...
Breaking Biology Technology:Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2Competition for graphene 2ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2
... ANGELES, Oct. 20 The Cure Our Children ... today,that the U.S. Food and Drug Administration (FDA) ... unique drug product for children with,Ewing,s Sarcoma cancer. ... possible,by the generous volunteers and researchers in private ...
... Oct. 20 On Wednesday, October,22, 2008, GlaxoSmithKline plc ... results for the three months ended September 30, 2008. ... Exchange at,approximately 12:00pm UK, 7:00 am EDT., At ... global teleconference,for analysts and investors, hosted by Andrew Witty, ...
... Oct. 20 Sustainable Oils has named ... as the company,s general manager. Scott Johnson ... to build camelina,production and marketing opportunities for ... joined the company on Oct. 1., ...
Cached Biology Technology:FDA Approves Orphan Drug Status for Revolutionary Cancer Drug for Children 2Sustainable Oils Names Scott Johnson as General Manager, Expands Management Team for Camelina Research and Production 2Sustainable Oils Names Scott Johnson as General Manager, Expands Management Team for Camelina Research and Production 3Sustainable Oils Names Scott Johnson as General Manager, Expands Management Team for Camelina Research and Production 4
ANTI S. ENT TOX BC2D...
Porcine Serum US Origin 6 Months or Older...
... PlusOne Silver Staining Kit, Protein, ... Heukeshoven and Dernick (1), the kit ... gel electrophoresis systems.Silver Staining Kit, Protein ... of proteins in polyacrylamide gels in ...
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
Biology Products: