Navigation Links
Protein important in diabetes may also play a key role in heart disease, other disorders
Date:7/21/2010

Studying a protein already known to play an important role in type 2 diabetes and cancer, genomics researchers have discovered that it may have an even broader role in disease, particularly in other metabolic disorders and heart disease. In finding unsuspected links to other disease-related genes, the scientists may have identified future targets for drug treatments.

The paper appeared online July 17 in the British journal Diabetologia.

"This protein could be a central player in many different diseases and traits," said study leader Struan F.A. Grant, Ph.D., a geneticist at The Children's Hospital of Philadelphia and a faculty member of the University of Pennsylvania School of Medicine. The current finding builds on Grant's 2006 discovery, now widely replicated, that a gene called TCF7L2 is strongly linked to type 2 diabetes.

Type 2 diabetes results either when the pancreas produces insufficient insulin or when the body's insulin-processing cells develop resistance to insulin, causing blood sugar to rise to unhealthy levels.

The TCF7L2 gene carries the code for a transcription factor--also called TCF7L2--a protein that binds to genes and regulates their activity. Exactly how this protein acts to affect diabetes is still unknown. However, Grant noted that there is great scientific interest in identifying which genes the transcription factor regulates. "It may be more feasible to develop drugs aimed at proteins encoded by specific gene classes regulated by TCF7L2 that are more amenable to targeted interventions, rather than aiming at a more ubiquitous transcription factor," he said.

Because variants in the TCF7L2 gene are also associated with risk for different cancers, including colorectal cancers, there was even greater reason to learn details of its biological activity. "Our goal," said Grant, "was to simply uncover the repertoire of genes that this transcription factor controls."

Collaborating wit
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. New role for the JNK protein
2. Supercharged proteins enter biologys forbidden zone
3. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
4. New retrieval method makes studying cancer proteins easier
5. Rice program takes on protein puzzle
6. Pitt researchers find new proteins that regulate blood pressure, flow
7. Map of herpes virus protein suggests a new drug therapy
8. TGen finds protein inhibitor revives chemotherapy for ovarian patients
9. CSHL team shows how loss of key protein promotes aggressive form of leukemia
10. Technique enables precise control of protein activity in living cells
11. Carbon nanotubes form ultrasensitive biosensor to detect proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a ... it is seeing a staggering demand from its licensees ... the Company revealed, is not solely coming from fitness ... as well. "A wearable is only as ... result, accuracy is the ultimate driver in long-term mass ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... a case of life imitating art, avian scents given off ... A Michigan State University researcher revealed the process of ... the current issue of Behavioral Ecology . Scents are ... attracting and evaluating mates. But this is the first study ...
... How is it that a disc-like cluster of cells transforms ... This mechanism is a mystery that man has tried ... towards understanding the issue was made nearly a century ago ... Hilde Mangold. The two used early newt embryos and identified ...
... expanded use of electronic health records (EHRs) to address ... system that can lead to readmissions and even death. ... JAMA , The Journal of the American ... using electronic health records to address patient safety issues," ...
Cached Biology News:Avian 'Axe effect' attracts attention of females and males 2Hebrew U. scientists show for first time how early human embryo acquires its shape 2E-health records should play bigger role in patient safety initiatives, researchers advocate 2
(Date:12/24/2014)... , Dec. 23, 2014  Rock Creek Pharmaceuticals, Inc., ... has filed a Clinical Trial Application (CTA) with the ... Regulatory Agency (MHRA) seeking regulatory approval to initiate clinical ... Anatabine Citrate. Contingent on the Company receiving ... Phase I trial to assess the safety, tolerability and ...
(Date:12/22/2014)... 22, 2014   Synthetic Biologics, Inc. ... pathogen-specific therapies for serious infections and diseases, ... today announced positive topline safety and tolerability ... of SYN-004, the Company,s investigational oral beta-lactamase ... difficile (C. difficile) infection, antibiotic-associated diarrhea ...
(Date:12/22/2014)... , Dec. 22, 2014 GenomeDx Biosciences ... Decipher Prostate Cancer Classifier, a genomic test for prostate ... node-negative, high-risk men managed by radical prostatectomy without adjuvant ... prostatectomy is relatively uncommon, using tumor genomics to identify ... metastatic disease is an important advance. The study has ...
(Date:12/22/2014)... 22, 2014 ITRA Global, one of ... of commercial real estate, has further expanded its global ... Perth and Brisbane, Western Australia, reports Mylinda Vick, CCIM, ... ITRA Global / ACORPP (Australian Corporate Property and ... company providing property services to a wide range of ...
Breaking Biology Technology:Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2
... and more. MADISON, Wis. My UW Madison ... and faculty for online organizational and scheduling tasksis migrating ... the project, Arizona-based Unicon, was also announced. , ,The ... be complete by August 2005. According to Brian Rust, ...
... Simon, left, and Charletta D. Flowers, right, who work for ... works for the Energizer Battery Company in St. Louis. ... of Milwaukee (YPM) threw an elaborate party at Milwaukee's ... ,The group had a lot to be proud of. In ...
... Islands in the Clickstream ... digital world. WTN will be reprinting excerpts from selected chapters of ... features an excerpt from chapter six, Mostly True Predictions. We hope ... A Vision of Possibilities , ,By Richard Thieme , ,It ...
Cached Biology Technology:"My UW Madison" portal migrating to uPortal 2Young Professionals of Milwaukee Celebrates Its Third Birthday, Looks To The Future 2Young Professionals of Milwaukee Celebrates Its Third Birthday, Looks To The Future 3Islands in the Clickstream: A Vision of Possibilities 2Islands in the Clickstream: A Vision of Possibilities 3Islands in the Clickstream: A Vision of Possibilities 4
... a compact, versatile system that simultaneously harvests ... 24-well microplates into a solid filter supports ... and gamma counter. The FilterMate is ideal ... such as cell proliferation, receptor binding, nucleic ...
... base medium for preparation of minimal and synthetic ... does not contain amino acids. Both bulk and ... contains reagents to prepare 500 ml of 10X ... 10X YNB for S. cerevisiae media. Store at ...
... based screening project: , 384 ... 96 shape-diverse mixtures of 4 (5 uL each) , ... Individual compounds are dissolved in DMSO at ... Supplied in 5 96-well trays. Dilute library with ...
... Assay Kits are ideal for studying ... compounds using fluorescence polarization (FP) The ... glutathione transferase to the ligand binding ... and a proprietary, fluorescently-tagged progesterone ligand, ...
Biology Products: