Navigation Links
Protein identified that can result in fragile bones
Date:7/27/2010

AUGUSTA, Ga. Too little of a protein called neogenin results in a smaller skeleton during development and sets the stage for a more fragile bone framework lifelong, Medical College of Georgia researchers report.

A developing mouse with neogenin deficits has poorly defined digits and is generally smaller, including having small growth plates, an indicator of future development, said Dr. Wen-Cheng Xiong, developmental neurobiologist in the MCG Schools of Medicine and Graduate Studies and corresponding author of the study published in Developmental Cell. Dr. Zheng Zhou, MCG assistant research scientist, is first author.

Their findings provide new insight into skeletal development as they point toward a potential new direction for treating osteoarthritis, a common, painful and debilitating condition where cartilage between bones is lost, Xiong said.

Neogenin doesn't make bone; rather, it forms a protein complex essential to turning on cartilage-producing genes, the researchers found. "Each cell type has a master gene. Neogenin is not that, it's more of a modulator," Xiong said. That's why, if it's mutated, like in the mouse, cartilage and bone formation is disrupted not halted. It's also why neogenin could be a good therapeutic target for turning the tide on cartilage or bone loss that occurs in osteoarthritis, Xiong said.

Skeletal development occurs early, which is why pregnant women need so much calcium. Initially the skeleton consists of soft bone or cartilage, which attracts blood vessels as well as the osteoblasts that replace most cartilage with hard bone over time. After birth, growth plates, where hard and soft bone meet, enable bones to lengthen and children to grow. After puberty, growth plates go away and bone hardens except for cartilage at the joints that eases movement and provides cushion. While bone cells continue to turn over, bone growth and loss should balance each other out after puberty due to o
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Engineered coral pigment helps scientists to observe protein movement
2. BU wins $1.6M NIH grant to target protein-protein interactions
3. A collaboration solves the herpes virus protein structure providing new drug therapy directions
4. Specific protein may help neurons fix themselves in Parkinsons patients
5. Protein important in diabetes may also play a key role in heart disease, other disorders
6. New role for the JNK protein
7. Supercharged proteins enter biologys forbidden zone
8. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
9. New retrieval method makes studying cancer proteins easier
10. Rice program takes on protein puzzle
11. Pitt researchers find new proteins that regulate blood pressure, flow
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein identified that can result in fragile bones
(Date:9/30/2014)... Sept. 30, 2014  Spectra Automation, a ... the biotech and power generation industries, announced ... Bioprocess Manager, an easy-to-use and cost-effective data ... bioprocess development laboratories. Most ... and analyzer systems. Accessing and consolidating data ...
(Date:9/29/2014)... study confirms that the exposure to tar tended to ... regular cigarettes. Similarly, exposure to nicotine tended to ... type of cigarette in several countries around the world. ... toxic chemicals in the smoke of these cigarettes are ... levels of chemicals in the smoke are not necessarily ...
(Date:9/29/2014)... Parents with children at home should use ventilation when ... University are recommending, after a new study showed an ... symptoms and chronic bronchitis. , "In homes where a ... asthma and wheezing is higher than in homes where ... Smit, an associate professor in the College of Public ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... CLEVELAND, Ohio - Cleveland Botanical Garden and Kent State ... pioneering scientific center for research in the field - ... research greenhouses on the Gardens campus. By ... the partnership could, in effect, control sunlight, extending the ...
... Pixelplus Co.,Ltd. (Nasdaq: PXPL ), ... designs,develops, and markets CMOS image sensors for ... unveiled the "PM1002", the Company,s,new ,System-On-A-Chip, ("SoC") ... PM1002 integrates a 32-bit RISC microprocessor and ...
... intricate transfer of information from a segment of DNA ... stationed in special "transcription factories" within a cell nucleus, ... II (Pol II) and other key molecules can assemble ... the gene,s position., The findings, published in the Dec. ...
Cached Biology News:Research project aims to control sunlight, extend growing season and conserve energy 2Pixelplus Unveils Its PM1002 as A Practical Biometric Solution for Iris, Facial and Fingerprint Recognition 2Pixelplus Unveils Its PM1002 as A Practical Biometric Solution for Iris, Facial and Fingerprint Recognition 3Research sheds light on the mechanics of gene transcription 2
(Date:10/1/2014)... , Oct. 1, 2014 Pfanstiehl has ... (USP/NF, EP), manufactured in the USA ... has long been recognized for playing a key ... growing body of evidence that media supplementation with ... of protein glycosylation," according to Dr. Christopher ...
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
(Date:10/1/2014)... Sept. 30, 2014 This report ... in US$ Million by the following Product ... Enzymes. Specific end-use segments also analyzed are ... The report provides separate comprehensive analytics ... Middle East, and Latin America. Annual estimates ...
(Date:9/30/2014)... of one of nature,s most efficient light-harvesting structures, ... by Alejandro Briseno of the University of Massachusetts ... long-sought polymer architecture to boost power-conversion efficiency of ... , Briseno, with colleagues and graduate students ... and Dresden University of Technology, Germany, report in ...
Breaking Biology Technology:Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3
... of its Board of Directors, held today, Wyeth (NYSE: ... of the Company.A dividend of thirty cents ($.30) per share on ... 1, 2009 to stockholders of record at the close of business ... cents ($.50) per share on the outstanding shares of Preferred Stock ...
... William White, Continental Airlines CEO Larry Kellner, and the ... CAMBRIDGE, Mass., April 23 TechConnect World today announced ... the TechConnect World trio of conferences -- ... TechConnect Summit events, at the George R. Brown Convention ...
... SQNM ), today announced that it will report first ... 2009. The company will conduct a conference call and an ... on the same day., Conference Call Information:, ... callers: 1 (706) 679-9912, , , Webcast information: ...
Cached Biology Technology:TechConnect World Conference Showcases Houston Leaders May 3-7, at the George R. Brown Convention Center 2TechConnect World Conference Showcases Houston Leaders May 3-7, at the George R. Brown Convention Center 3SEQUENOM to Hold First Quarter 2009 Financial Results Conference Call on April 30 2
Rabbit polyclonal to MDM2 (phospho S185) ( Abpromise for all tested applications). entrezGeneID: 4193 SwissProtID: Q00987...
ASCIZ...
...
Yields DNA greater than 50 kb in length from yeast, fungi, Gram neg. and Gram pos. bacteria...
Biology Products: