Navigation Links
Protein identified that can result in fragile bones
Date:7/27/2010

AUGUSTA, Ga. Too little of a protein called neogenin results in a smaller skeleton during development and sets the stage for a more fragile bone framework lifelong, Medical College of Georgia researchers report.

A developing mouse with neogenin deficits has poorly defined digits and is generally smaller, including having small growth plates, an indicator of future development, said Dr. Wen-Cheng Xiong, developmental neurobiologist in the MCG Schools of Medicine and Graduate Studies and corresponding author of the study published in Developmental Cell. Dr. Zheng Zhou, MCG assistant research scientist, is first author.

Their findings provide new insight into skeletal development as they point toward a potential new direction for treating osteoarthritis, a common, painful and debilitating condition where cartilage between bones is lost, Xiong said.

Neogenin doesn't make bone; rather, it forms a protein complex essential to turning on cartilage-producing genes, the researchers found. "Each cell type has a master gene. Neogenin is not that, it's more of a modulator," Xiong said. That's why, if it's mutated, like in the mouse, cartilage and bone formation is disrupted not halted. It's also why neogenin could be a good therapeutic target for turning the tide on cartilage or bone loss that occurs in osteoarthritis, Xiong said.

Skeletal development occurs early, which is why pregnant women need so much calcium. Initially the skeleton consists of soft bone or cartilage, which attracts blood vessels as well as the osteoblasts that replace most cartilage with hard bone over time. After birth, growth plates, where hard and soft bone meet, enable bones to lengthen and children to grow. After puberty, growth plates go away and bone hardens except for cartilage at the joints that eases movement and provides cushion. While bone cells continue to turn over, bone growth and loss should balance each other out after puberty due to o
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Engineered coral pigment helps scientists to observe protein movement
2. BU wins $1.6M NIH grant to target protein-protein interactions
3. A collaboration solves the herpes virus protein structure providing new drug therapy directions
4. Specific protein may help neurons fix themselves in Parkinsons patients
5. Protein important in diabetes may also play a key role in heart disease, other disorders
6. New role for the JNK protein
7. Supercharged proteins enter biologys forbidden zone
8. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
9. New retrieval method makes studying cancer proteins easier
10. Rice program takes on protein puzzle
11. Pitt researchers find new proteins that regulate blood pressure, flow
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein identified that can result in fragile bones
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- LiveScan ... has agreed to a partnership with Gabriel Health ... fastest growing Certified Nursing Assistant preparatory ... Institute  an exclusive member of Binary,s LiveScan service ... Biometrics will improve its service capabilities by ...
(Date:8/21/2014)... at improving the food intake, health and quality of ... among three projects at the University of Waterloo receiving ... Institutes of Health Research (CIHR). , Professor Heather ... Waterloo, and a Schlegel research chair in nutrition and ... why many Canadians living in long-term care homes are ...
(Date:8/21/2014)... BOSTON -- Nine researchers from Beth Israel ... included in "The World,s Most Influential Scientific Minds ... from Thomson Reuters ScienceWatch, a web resource for science ... scientists recognized as among the most influential "are performing ... to the advancement of their science," according to a ...
Breaking Biology News(10 mins):LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3Grants will fund landmark aging research at Waterloo 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... United Nations Intergovernmental Panel on Climate Change (IPCC) have warned ... achieve a stable climate on our planet by the end ... coming decades must be curbed before the emissions can be ... CO2 emissions that can be tolerated globally by the end ...
... genetically modified crops, according to new research funded by ... A group at the Open University, led by Professor ... what large-scale, commodity farmers not those mainly involved ... know how consumers, governments and the food industry regard ...
... University of Nottingham could have a major impact on the ... to stay in work. Back pain is one of ... In 2004-5 approximately 34,000 people in the East Midlands suffered ... caused or made worse by their current or past work. ...
Cached Biology News:ETH Zurich competence center ESC introduces energy strategy 2ETH Zurich competence center ESC introduces energy strategy 3What farmers think about GM crops 2Helping back pain sufferers to stay in work 2
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... and Mexico ... several newly approved agents, the anticipated label extension ... the launch of emerging biologics will substantially increase ... the emerging IL-5 inhibitors will introduce a new dynamic ...
(Date:8/21/2014)... 2014 Pursuit Solutions ( http://www.pursuit-solutions.com ... and services for Life Sciences sales and marketing ... of New Commercial Sales Models” by Peter Robinson, ... The article examines some innovative models used to ... tested in the pharmaceutical market. Robinson grades the ...
(Date:8/20/2014)... 20, 2014 Clintrax Global, Inc., a ... Raleigh, NC , recently announced ... Vice President of Administration. As ... corporate processes, including their alignment with company objectives ... worked as an HR executive, specializing in needs ...
(Date:8/20/2014)... Livermore, California (PRWEB) August 20, 2014 ... to develop and apply the most complete climate ... challenging and demanding climate change issues. , Eight ... combining forces with the National Center for Atmospheric ... in the new effort. Other participating national laboratories ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2Clintrax Global, Inc. Announces Addition to Executive Team 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... April 23 ImaRx Therapeutics,Inc. (Nasdaq: IMRX ... an agreement,with Abbott Laboratories pursuant to which it ... promissory note with Abbott issued in,connection with its ... to,the urokinase assets, including the remaining inventory of ...
... PHILADELPHIA, April 23 BioNanomatrix, Inc. today,announced that ... honored at the,14th Annual Ben Franklin Emerging Business ... Management Team category, competing with a,strong group of ... executive officer Dr. Michael Boyce-Jacino accepted the,award on ...
... Calif., April 23 SectorWatch.biz announces the,availability ... news and driving,markets today within the biotechnology ... on the aforementioned equities and the,opportunity for ... on the,subject and sector., Investors can ...
Cached Biology Technology:ImaRx Therapeutics Satisfies Abbott Note Obligation Associated With the Acquisition of Urokinase 2ImaRx Therapeutics Satisfies Abbott Note Obligation Associated With the Acquisition of Urokinase 3BioNanomatrix Named 'Best Management Team' at the 2008 Ben Franklin Emerging Business Awards 2SectorWatch.biz Issues MarketStats on KBLB, DGX, LH, BRLI, and ABT 2SectorWatch.biz Issues MarketStats on KBLB, DGX, LH, BRLI, and ABT 3
... kits are designed to rapidly and reliably ... patented APA Technology. APAgene provides hassle-free, ready-to ... All necessary ingredients are provided in each ... used for gap filling, localized cloning of ...
N,N'-Methylene-bis-acrylamide, Ultra Pure...
... product is designed to deparaffinize and perform ... fixed paraffin-embedded tissue sections mounted on glass ... the paraffin at the high temperature used ... emulsification of the paraffin by detergent. Formaldehyde ...
... product is designed to deparaffinize and perform ... fixed paraffin-embedded tissue sections mounted on glass ... the paraffin at the high temperature used ... emulsification of the paraffin by detergent. Formaldehyde ...
Biology Products: